What Is Pentazocine?

Pentazocin is also known as pantazocin (Pentazocine for Hong Kong, Macao and Taiwan); Sucikang (for Hong Kong, Macao and Taiwan); Analgesic New, is an opioid receptor agonist / antagonist analgesic. The active ingredient of this product is pentazocine, and the auxiliary materials are sodium chloride and lactic acid. Pentazocin combined with etomidate is used for painless gastroscopy of the elderly. The anesthetic effect is satisfactory, the hemodynamics is stable, and the adverse reactions are few. It is one of the safe and reliable anesthesia methods for this kind of surgery.

Drug Name: Pentazocine
Alias: Panthazol
Accessories: Sodium chloride, lactic acid

Molecular formula: C19H27NO
Molecular weight: 285.43
Character: Almost colorless clear liquid

Pentazocine Ingredients

Chemical name of active ingredient 1,2,3,4,5,6-hexahydro-cis-6,11-dimethyl-3 (3-methyl-2-butenyl) -2,6- Methylidene-3-benzoazepine-8-ol.

Chemical Structure:

Molecular formula: C19H27NO

Molecular weight: 285.43

Pentazocine Product Features

The first clinically applied opioid receptor agonist / antagonist analgesic can provide analgesic effects similar to opioids such as morphine and duolidine; parenteral administration produces rapid and strong analgesic effects, and the duration of action Shorter than morphine and dulentin; Central inhibitory effect is lighter, especially lighter than other opioids in terms of respiratory depression and nausea and vomiting; no hypotensive response; drug dependence is less than other opioids; does not affect mood; moderate half-life Its suitable half-life is suitable for a variety of operations, and the sequelae of the operation are quickly eliminated; it can be administered by multiple routes such as intramuscular injection, subcutaneous, intravenous, pumping, etc .;

Pentazocin Conventional Dosage

(1) The maximum daily dosage cannot exceed 180mg;

(2) intramuscular injection of q6h (30mg every 6 hours) or q8h (30mg every 8 hours), mainly for patients with tumor cachexia.

(3) Intravenous drip of 30mg and 250ml of normal saline or glucose, the drip rate should be controlled below 20 / min, and excessive speed should not be avoided;

(4) Usage of PCA during the perioperative period (should be based on the capacity of the reservoir of the analgesia pump):

If the storage sac has a capacity of 100ml, add 10 mg of metoclopramide (to prevent gastrointestinal reactions) and add 3 pieces of pentazocine (90mg) combined with physiological saline. Semensone prevents stress response. If the 48-hour postoperative analgesic is met, the above-mentioned dose should be added for continued use the next day. If the storage sac has a capacity of 200ml, you can add 150-180mg pentazocine and 15-20mg Metoclopramine combined with 200ml total saline, 4ml / h, 48h after pumping, and intramuscular injection of dexamethasone to prevent surgery caused Irritability.

Pentazocine specific clinical use

Pentazocine anesthesia during perioperative period:

(1) Tracheal intubation: 0.8mg / kg ["Feasibility Study of Pentazocine for Induction of General Anesthesia and Tracheal Intubation" "Hebei Medical Journal, Vol. 14, No. 7, 2008"

(2) Induction of anesthesia: 0.5mg / kg [Clinical observation of pentazocine and ketamine combined general anesthesia for abdominal surgery in patients with drug addiction]

(3) Intraoperative maintenance: 1. Intravenous pump: 10 g / kg / min [Chinese Journal of Postgraduates of Medicine, May 25, 2007, Volume 30, Issue 5 Comprehensive Edition]

2. Intravenous infusion: 30mg pentazocine + 250ml saline / glucose, low speed control below 20 drops / min

(B) Postoperative analgesia:

PCEA Pentazocine PCEA

1. Analgesic for 24 hours: 90mg pentazoxine + 10mg metoclopramide + 100ml physiological saline is placed in a 100ml analgesic pump, 4ml / h, and the pump is completed within 24 hours.

2. Analgesic for 48 hours: 150 180mg of pentazoxine + 15 20mg of metforman + 200ml of normal saline was placed in a 200ml analgesic pump, 4ml / h, and the pump was finished in 48 hours.

Pentazocin Compatible with L-Bupivacaine

Dispensing method: 0.75% levobupivacaine 25ml + pentazocine 12mg + physiological saline diluted to 50ml

LPC mode: loading dose is 5ml, continuous dose is 1ml / h, single dose is 2ml, lock time is 10 minutes, and analgesia is 24 hours.

[Effects of Pentazocin Compatible with L-Bupivacaine on Epidural PCA [Guangzhou Medicine] 2008 Vol. 39 No. 5]

PCIA Pentazocine PCIA

1. A bolus of 3mg, locked for 5-10 minutes

2. Continuous infusion: flow rate 1.5 2.5mg / h

3. Rapid infusion: 5 10mg / time, lock time 10 15min

[Pentazoloxine intravenously controlled analgesia Masui. 2006 Apr; 55 (4): 428-30]

4. Subcutaneous continuous infusion (CSI) rate 0.5ml / h Dispensing method: Pentazocine 240 390mg, droperidol 5mg, 1% lidocaine, administration volume 40ml

[Continuous subcutaneous infusion of pentazocine for analgesic effect after lower abdominal surgery Masui. 2005 Jun; 54 (6): 627-31]

PCA Pentazocin for PCA analgesia after hysterectomy

Pump A: epidural pump 0.2% levobupivacaine 4ml / h

Pump B: Intravenous PCA pump sprays tazocine 60mg + normal saline 40ml

Loading dose 7.5mg / 5ml

PCA supplement (bolus) 3mg / 2ml

Lock time 5min

4 hours maximum 10ml

[Effects of Pentazocin on PCA Effect in Patients After Transabdominal Hysterectomy. "Guangdong Medical Journal" Volume 28 Number 11 November 2007]

(5) In accordance with the application of propofol intravenous anesthesia in hysteroscopy. Intravenous pentazocine 0.4 mg / kg, 2 to 4 minutes after intravenous injection of propofol 1 to 2 mg / kg (2 mg / s)

[Application of Pentazocin Combined with Propofol Intravenous Anesthesia in Hysteroscopy [Modern Hospital] December 2008 Vol. 8 No. 12]

Pentazocin for multimodal analgesia

Tazozocin was injected intramuscularly 30 minutes before the end of the operation. After intravenous PCA analgesia, the analgesic pump is in CP mode (continuous infusion + single addition), using pentazocine 90 + antiemetic + normal saline to 90ml (ie 0.1% pentazocin complex solution ). Continuous infusion volume 3 ml, additional dose 5 ml; PCA lock time is 20min

[Pentazoxine intramuscular injection combined with intravenous PCA for analgesia after laparoscopic hysterectomy. "Guangdong Medical Journal, Vol. 31, Issue 10, 2010"]

Pentazocin for the prevention and treatment of acute hyperalgesia after general anesthesia

Inject intramuscular injection of 30 mg pentazocine 15-20 minutes before the end of the operation (diluted to 5 ml with 0.9% physiological saline) to effectively reduce remifentan

Postoperative acute hyperalgesia in general anesthesia patients, and does not prolong tracheal tube removal time after general anesthesia, is used to prevent and treat postoperative acute hyperalgesia and

No obvious adverse reactions. There was no significant effect on breathing and wake time.

[Pentazoloxine for the prevention and treatment of acute hyperalgesia after remifentanil general anesthesia "Guangdong Medical Journal, Volume 31, Issue 10, 2010]

Analgesic effect of pentazocine combined local anesthetic

Method (1) Pentazocine 30mg is mixed with local anesthetic (local anesthetic is 2% lidocaine 10ml + 1% ropivacaine 10ml) for brachial plexus nerve

Block method (2) Pentazocine 30 mg compound 0.4% ropivacaine 30ml for brachial plexus nerve block Pentazocine compound local anesthetic for brachial plexus nerve

Blockade can obviously enhance the postoperative analgesic effect and prolong the postoperative analgesic time with minor adverse reactions.

[Pentazoxine combined local anesthetic for postoperative analgesic effect of brachial plexus block] [Guangdong Medical Journal, Volume 31, Issue 10, 2010]

Pentazocin inhibits stretch response in abdominal surgery in elderly patients

Pentazocin 0.3mg / kg + midazolam 0.03 mg / kg iv before skin incision after anesthesia, Pentazocin can safely and effectively inhibit abdominal surgery traction in elderly patients

Reaction, the combined use of midazolam is more effective.

[Clinical observation of pentazocine in inhibiting the traction reaction of abdominal surgery in elderly patients. [Guangdong Medical Journal] Volume 31, Issue 10, 2010]

Pentazocin combined with propofol in painless colonoscopy

Slowly inject 0.5mg / kg Pentazine diluent 2ml, and then inject propofol 1mg / kg ~ 1.5mg / kg 2 minutes later.

Painless colonoscopy is a safe and effective method. The anesthetic effect is better than the single application of propofol.

Dosage, shorten the recovery time of patients, can reduce the incidence of postoperative adverse reactions.

[Pentazocine and Propofol in Painless Colonoscopy "Guangdong Medical Journal, Volume 31, Issue 10, 2010]

Application of different doses of Pentazocin in painless abortion

Intravenous injection of 0.2 mg / kg or 0.4 mg / kg pentazocine, followed by 2 minutes of propofol 2.0 mg / kg (1000 ml / h). Conclusions 0.2 mg / kg and

0.4mg / kg Pentazocin combined with propofol for artificial abortion can significantly reduce the amount of propofol, wake up quickly, high safety, and analgesic effect

it is good.

[Application of different doses of Pentazocine in painless abortion "Guangdong Medical Journal, Volume 31, Issue 10, May 2010]

Application of Pentazocin Advance Analgesia in Induced Abortion

10 minutes before the operation, 30 mg of pentazocine was intravenously injected and 2 mg / kg of propofol was intravenously injected for general anesthesia induction. The propofol injection rate was 15 ml / min.

After the patient's eyelash reflex disappeared, the operation was started. The patient was given 1 mg / kg of propofol when body movement occurred during the operation. Conclusion Pentazocin 30mg ahead of town

Pain used in induced abortion has similar analgesic effect to fentanyl 1 g / kg, but no respiratory depression of fentanyl, and its preferred timing for administration

10 minutes before surgery.

[Application of Pentazocin Advance Analgesia in Induced Abortion "Guangdong Medical Journal, Volume 31, Issue 10, May 2010]

Effects of intravenously controlled analgesia with pentazocine on maternal prolactin levels

Give analgesic solution via intravenous indwelling needle infusion tube 10min before the end of the operation: Pentazocine 300 mg + antiemetic; analgesic time 48h, background flow

2ml / h, PCA 0.5ml / time, locking time 15min; Results: Plasma PRL levels were significantly higher in the two analgesic groups at 24h and 48h after operation ( P <

0.01), VAS score was lower than the control group ( P <0.01). CONCLUSION: Pentazocin-controlled intravenous analgesia is effective after cesarean section and can promote secretion.

Lactin secretion.

[Effects of intravenously controlled analgesia with pentazocine on maternal prolactin levels [Guangdong Medical Journal, Volume 31, Issue 10, 2010]

Pentazocin ultrasound-guided transvaginal egg retrieval

Before the operation, 30 mg of Azazatron, 0.5 mg of Atropine, 20 mg of Pentazine, and 2.0 mg / kg of propofol were given intravenously slowly. Treat patients

After the eyelash reflex disappeared, the operation was started. During the operation, propofol 0.2 mg / kg was added as needed (patients showed body movement, moaning, frowning, etc.). in conclusion

Anesthesia effect of pentazocine 20mg combined with propofol compared with fentanyl 50g combined with propofol in transvaginal ultrasound oocyte anesthesia

Similar, but respiratory depression, wake-up time and postoperative adverse reactions were significantly reduced.

[Effects of pentazocine and propofol intravenous anesthesia on ultrasound-guided transvaginal egg retrieval [Guangdong Medical Journal, May 2010, Volume 31]

Pentazocin combined with levobupivacaine for analgesia after cesarean section

120 cases of cesarean section primiparas (ASAI-II) were randomly divided into six groups (n = 20), with 0.1%, 0.12%, 0.14%, and 0.1%, respectively.

16%, 0.18%, 0.2% pentazocine and 0.2% levobupivacaine were all administered in LCP mode: loading dose 5ml,

Background dose 2ml · h , single additional dose 2ml, lock time 15min, analgesia 24h, self-controlled epidural analgesia after cesarean section

(PCEA) effects and the effects of adverse reactions.

Conclusion: 0.18% or 0.2% pentazocine plus 0.2% levobupivacaine for PCEA after maternal cesarean section has a good effect, which is better than

0.1%, 0.12%, 0.14%, or 0.16% pentazocine complex 0.2% levobupivacaine, no increase in adverse reactions; can be used as

One of the preferred analgesic options after cesarean section.

[Chinese Journal of Pain Medicine, 2010, 16, (3), 143-147]

Pentazocin is used for analgesia after lower limb surgery in the elderly

Ninety-six elderly patients with ASA1I-III elective lower extremity fractures were randomly divided into 3 groups of 32 patients each. Group I: Pentazocin 20g · kg-1 · h -1 + Fentan

0.1 g · kg-1 · h -1; Group II: Pentazocine 4Og · kg-1 · h -1 + Fentanyl 0.1 g · kg-1 · h -1; Group III: Pentazol Zosin

60 g · kg-1 · h -1 + Fentanyl 0.1 g · kg-1 · h -1. All three groups were treated with PCIA after surgery, with a continuous infusion volume of 2ml · h-1 and a single dose.

(PCA) 1.5 ml, locking time 15 minutes. Observe MAP, HR, RR, SpO2 and corresponding time points after 4, 8, 24, 48 h

Analgesia, sedation score and adverse reactions. Results The analgesia satisfaction of group was significantly higher than that of group I (P <0.05).

The incidence was significantly lower than that in group III (P <0.05). Conclusion 40 g · kg-1 · h -1 of pentazocine is effective in the analgesia of lower limb fractures in the elderly.

It has fewer side effects and can be safely used for postoperative analgesia in elderly patients.

[Anhui Medicine 2010,9,14 (9), 1070-1071]

Comparison of clinical effects of postoperative analgesia with pentazocine

A total of 40 patients with elective upper abdominal surgery were selected and randomly divided into two groups, group P (pentazoxin group, n = 20), and 150mg of petazozine. Fentanyl

5mg, tropisetron 5mg, O. 9% physiological saline was added to 100 ml; group F (fentanyl group, n = 20), fentanyl 1. Omg, Tropanisetron

5mg, 0.9% saline was added to 100ml. Choose a loading dose plus a maintenance dose, i.e., continuous delivery by a micropump for intravenous analgesia (loading dose

2ml, maintaining the injection rate at 2. Oml / h, single PCA dose! Ml, lock time 30min). Observe after 2, 4, 8, 12, 24 h

Visual analogue score (VAS), Ramesay sedation score, and patient's comprehensive satisfaction score for PCA were recorded at 2, 4, 8, 12, and 24 hours after surgery.

The number of times the PCA pump is pressed (D1) and the actual number of times of entry (D2).

Results There were no significant differences in analgesia scores, nausea and vomiting in group P compared with group F. The sedation score was better in group P than in group F. Conclusion Pentazocine is effective for postoperative intravenous analgesia, has a good sedation effect, and has fewer adverse reactions.

[Journal of Clinical Medicine, Vol.17, No.14, July 2008, 84-86]

Comparison of the efficacy of pentazocine and morphine in self-controlled analgesia after surgery

Sixty patients with esophageal cancer surgery (ASA ) were selected and randomly divided into two groups (groups A and B) with 30 cases in each group. Among them, group A is Pentazocin group, Pentazo

Zoxine 180mg; B is morphine group, morphine 0.03mg / (kg · h). Both groups of postoperative analgesics were treated with disposable non-electric intravenously controlled infusion pumps.

The flow rate is 2 ml / h and the capacity is 100 ml. Observe the analgesic effect and adverse reactions after surgery.

Results: There was no significant difference in analgesic effect between the two groups; nausea and vomiting: 0 cases in group A, 3 cases (10%) in group B; mild itching of skin: 0 cases in group A; 1 case (3.3%) in group B . Conclusion: Pentazocin PCA, like morphine, can achieve good analgesic effects, but the incidence of adverse reactions is low.

["Chinese National Medicine" 2008 Vol.20 No.20]

Pentazocin and morphine for postoperative low epidural analgesia

Selective surgery was performed in 180 patients, grade ASA , and randomly divided into two groups. Group M (n = 90 cases) selected morphine 10mg plus bupivacaine hydrochloride 150mg plus

Normal saline to 100ml. In group N, pentazocine 120 mg, bupivacaine hydrochloride 150 mg, and physiological saline were added to 100 ml. In LCP mode (load

5ml plus maintenance amount 2ml / h plus PCA 0.5ml each time) for analgesia.

Results: Both M group and N group had good analgesic effect without significant statistical significance (P> 0.05), but the incidence of adverse reactions such as nausea, vomiting, itching of the skin, urinary retention and respiratory depression in the M group was significantly higher than that in the N group. Group (P <0.05). CONCLUSION: Both pentazocine and morphine have good effects on epidural analgesia, but the adverse reaction rate of morphine is significantly higher than that of pentazocine.

[Journal of Qiqihar Medical College 2010]

Pentazocine Pentazocin is used for painless gastroscopy in the elderly

80 elderly patients with gastroscopy. Randomly divided into two groups. In group A, 5rain was injected intravenously with pentazocine before operation. 4mg / kg, group B, 5min before surgery

Intravenous infusion of fentanyl lug / kg, group A was slowly injected intravenously with etomidate 0.15 to 0.3 mg / kg 1 min before the start of the test, and group B was checked

In the first 1min, intravenous injection of propofol 1.5-2mg / kg was applied to patients who were treated with pentazocine plus etomidate as group A (40 cases) and fentanyl complex

Those in propofol group B (40 cases). The intraoperative analgesic effect, respiratory depression, postoperative nausea, vomiting, and dizziness were compared between the two groups.

Results: After the anesthesia, the blood pressure of group A and group B decreased to varying degrees. The decrease in group B was more obvious. The incidence of respiratory depression in group A was significantly lower than that in group B. Conclusion Pentazocin combined with etomidate was painless in the elderly Gastroscopy has a satisfactory anesthesia effect, stable hemodynamics, and few adverse reactions. It is one of the safe and reliable anesthesia methods for this kind of surgery.

[Clinical Medicine Medical Information, Vol. 23, Issue 4, April 2010, 890-891]

Pentazoloxine in combination with propofol for painless abortion

120 cases of painless humans were divided into intravenous anesthesia with tacitrazine or fentanyl combined with propofol.

After injecting 1 g · kg-1,2 min of fentanyl, the two groups were induced by intravenous injection of 2 mg of propofol within 1 min. The mean arterial pressure (MAP), HR, SP02, consciousness were observed.

Disappearance time (injection to the disappearance of Mu Mao reflection), consciousness recovery time, statistical analysis and measurement. The data are expressed as (X ± S) and t test is used.

CONCLUSION: Pentamidine and propofol combined with propofol are used for painless abortion surgery. The analgesic effect is accurate, the respiratory depression is small, the safety is high, and it is worth popularizing.

["Straits Pharmacy", Volume 19, Issue 12, 2007, 96-97]

PCA PCA Effect of Patients after Pentazocin Total Abdominal Hysterectomy

Forty patients undergoing total abdominal hysterectomy, ASA , were randomly divided into two groups: pentazocine group (P group) and morphine group (M group).

The double-blind method was used for double-blind control observation. Pump A: the two groups were given a continuous epidural infusion of 0.2% levobupivacaine 4ml / h; pump B:

0.15% pentazocine was enhanced by PCIA, PCA was in P mode, and the analgesic drug was (pentazocine 60mg plus droperidol 2mg diluted with normal saline

Released to 40ml), the additional dose of PCA (bolus) is 3mg, lock time is 5min, the maximum dose of 4h is 40mg. M group was reinforced with morphine PCIA, which

Analgesics (40mg morphine plus droperidol 2mg diluted with physiological saline to 40ml), PCA additional dose (bolus) is 1mg, when locked

After 5min, the maximum dose of 20mg was 4h. Analgesic effect was evaluated by visual analogue scores at 1, 2, 4, 6, 8, 12, 16, 18, and 24 hours after surgery

(VAS), Ramesay Sedation Score, Postoperative Motor Nerve Block Recovery Score (Modified Bromage Classification), and Patient Satisfaction with PCA

Degree score, record 0 1h, 1 2h, 2 4h, 4 6h, 6 8h, 8 12h, 12 16h, 16 18h, 18 24h PCA

The number of times the pump is pressed (D1) and the actual number of entries (D2), and the anal exhaust time and possible adverse reactions are recorded.

Results: The general situation of the two groups of patients was similar; the dosage of epochal levobupivacaine was 192 mg in 24 hours; 2 patients (10%) in the P group and the M group who did not press the PCA pump; The 24h intravenous doses in group M were (20.25 ± 13.05) mg and (4.7 ± 3.5) mg, respectively; there were 1 patient (5.0%) in group P who had nausea and vomiting during the entire PCA analgesia period; and group M had 3 cases (15.0%). One patient (5.0%) in the M group had mild itching in the skin; the P group did not. The VAS, Ramesay sedation score, Bromage rating, and D1 / D2 values were similar among the three groups in the same time period. Conclusion Based on 0.2% levobupivacaine continuous epidural infusion (4ml / h), both the opioid receptor agonist pentazocine and intravenous morphine PCA can achieve a good analgesic effect. The ratio of tazocine to morphine is about 4: 1.

["Clinical Drug Research", 2007, 11:28, 11: 1838-1839]

Analysis of the efficacy of pentazocine in the treatment of acute alcoholism

There were 294 patients in the treatment group, including 268 males and 26 females, with an average age of 36.4 years. The average person consumed 365 mL of alcohol and pentazocine alone. 232 cases in the control group, whose

There were 212 males and 20 females, with an average age of 35.8 years. The average person consumed 350 mL of alcohol, using conventional methods. There was no significant difference in the general situation of the two groups of patients

(P> 0.05), with comparability. Treatment group: intravenous injection of pentazocin hydrochloride, mild poisoning 4, _8 mg, severe 8-12 mg, repeated 4-5-1 h

8 mg until the patient is conscious. Control group: the conventional method: intravenous injection of 5000 glucose solution, rehydration, application of mannitol, furosemide, pancreas

Island prime and so on. Results: There was a significant difference between the treatment group and the control group (P <0.01). For those with respiratory depression and decreased blood pressure, use spray

After Zoxin, the breathing was obvious and improved, and the blood pressure rose rapidly. No adverse reactions were found during treatment. Conclusion: Pentazocin for acute ethanol

Poisoning is superior to conventional treatment methods in awakening, shortening the course of disease, improving the cure rate, and reducing the mortality rate.

[Journal of Practical Diagnosis and Therapy, 2006, Vol. 20, No. 8]

Pentazocin to prevent agitation in patients with remifentanil under general anesthesia

Methods: 150 cases of laparoscopic cholecystectomy under general anesthesia were divided into group A, group B and group C, 50 cases each. The three groups of anesthesia protocols are the same.

After stopping general anesthesia, group A was intravenously injected with 10 mL of normal saline; group B was intravenously injected with 1 g / kg of fentanyl: group C was intravenously injected with 0.35 mg / kg pentazocine. Record separately

Respiration frequency before anesthesia, time of anesthesia, questioning of spontaneous breathing recovery, questioning of extubation, sedation during extubation, restlessness (RASS) score and extubation

Respiratory frequency after 5 min. Results: Compared with group A, the incidence of agitation in groups B and C was lower (P <0.05), and group C was more autonomous than patients in group B

The effects of breathing recovery time and extubation time were smaller, there was no significant difference between group C and group A (P> 0.05), and there was significant difference between group B and group A

(P <0.05) Conclusion: Propofol remifentanil under general anesthesia for laparoscopic cholecystectomy patients was given 0.35 mg / kg pentazocine before general anesthesia.

It can effectively prevent the occurrence of restlessness in the awake period, and is better than low-dose fentanyl.

[Modern Practical Medicine, Vol. 21, Issue 7, July 2009]

Pentazocine

This product is a clear liquid that is colorless to almost colorless.

Pentazocine indications

Applicable for analgesia in various surgical anesthesia, can be used for induction of anesthesia, intraoperative anesthesia, postoperative analgesia, etc .; suitable for postoperative analgesia in various surgical departments; suitable for analgesia in various endoscopic procedures; suitable for Painless painless analgesia; suitable for cancer patients;

Pentazocin Specifications

1ml: 30mg

Pentazocine manufacturing enterprise

Asia: Beijing Shuanghe Pharmaceutical Co., Ltd.

North America: Sterling Pharmaceuticals

Europe: No

Africa: No

Oceania: No