What Is Polymyxin B Sulfate?

Polymyxin B sulfate for injection is mainly used for wound, urinary tract, and eye, ear, and trachea infections caused by Pseudomonas aeruginosa and other pseudomonas, and can also be used for sepsis and peritonitis.

Drug Name: Polymyxin B Sulfate for Injection

Drug type: Prescription drugs, medicines for medical workers' injuries
Use classification: Antibiotics

Polymyxin B Sulfate for Injection

This product is a sterile powder of polymyxin B sulfate.

Polymyxin B Sulfate for Injection

Its sulfate is commonly used as a white crystalline powder, easily soluble in water, and hygroscopic. Stable in acidic solution, neutral solution does not affect titer when stored at room temperature for one week, alkaline solution is unstable.

Polymyxin B Sulfate for Injection Indications

It is mainly used for wound, urinary tract, eye, ear, trachea and other infections caused by Pseudomonas aeruginosa and other pseudomonas, and can also be used for sepsis and peritonitis.

Polymyxin B Sulfate for Injection Specification

Polymyxin B sulfate for injection: 50 mg per bottle (1 mg = 10,000 units).

Polymyxin B Sulfate for Injection

1. Intravenous adults and children with normal renal function 1.5 to 2.5 mg / kg (usually no more than 2.5 mg / kg) per day, divided into two, instilled once every 12 hours. Each 50mg of this product is diluted with 500ml of 5% glucose solution and dripped. Infants with normal renal function can tolerate a dose of 4mg / kg per day.
2. Intramuscular injection for adults and children: 2.5 3mg / kg per day, divided administration, once every 4-6 hours. The daily dose is 4mg / kg for infants and 4.5mg / kg for newborns.
3. Intrathecal injection (for Pseudomonas aeruginosa meningitis) A 5 mg / ml medicinal solution was prepared with sodium chloride injection. Adults and children over 2 years old, 5 mg daily, after 3 to 4 days of application, changed to once every other day, at least 2 weeks, until the cerebrospinal fluid culture was negative, and the sugar level was normal. For children under 2 years old, take 2 mg once daily for 3 to 4 days (or 2.5 mg once every other day), and then use 2.5 mg once every other day until the test is normal.
4. Eye drops have a concentration of 1 to 2.5 mg / ml.

Polymyxin B Sulfate for Injection

Damage to the kidney is more common, and those with renal insufficiency should be reduced.
Intravenous injection may cause respiratory depression and is generally not used.
The amount of intrathecal injection should not exceed 5mg to prevent irritation of the meninges or nerve tissue.
Should not be combined with other drugs with renal toxicity or neuromuscular blockade to avoid accidents.

Precautions for Polymyxin B Sulfate for Injection

1. Damage to the kidney is more common, and those with renal insufficiency should be reduced.
2. Intravenous injection may cause respiratory depression and is generally not used.
3. The amount of intrathecal injection should not exceed 5mg at a time to prevent irritation of the meninges or nerve tissue.

Polymyxin B Sulfate for Injection Drug Interactions

Should not be combined with other drugs with renal toxicity or neuromuscular blockade to avoid accidents. Avoid combination with nephrotoxic drugs. Should not be combined with skeletal muscle relaxants, aminoglycoside antibiotics, anesthesia drugs with obvious muscle relaxation effects (such as enflurane), etc. It is also not allowed to apply quinine and magnesium at the same time. Used in combination with sulfa drugs, rifampicin, semi-synthetic penicillin, etc., for the treatment of severely resistant Gram-negative bacterial infections, the effect is better than alone.

Polymyxin B Sulfate for Injection Pharmacology and Toxicology

It has antibacterial effect on Pseudomonas aeruginosa, E. coli, Klebsiella pneumoniae, and gram-negative bacteria such as Haemophilus, Enterobacter, Salmonella, Shigella, Pertussis, Pasteurella and Vibrio. Proteus, Neisseria, Serratia, Pluviden, Gram-negative and obligate anaerobic bacteria are not sensitive to this class of drugs. Bacteria have cross-resistance to this product and polymyxin E, but no cross-resistance has been found between this class of drugs and other types of antibacterials. Not absorbed orally. It is mainly excreted by urine after injection, but only a small amount is excreted within 12 hours, and it can reach a concentration of 20 to 100 g / ml in the future. Drug excretion continues within 1 to 3 days after discontinuation. ^[1]