What Is Rabeprazole Sodium?
Proton pump inhibitors for diseases caused by hyperacidity. Such as gastric and duodenal ulcers, esophageal reflux disease and so on.
Rabeprazole sodium
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- Chinese name: Rabeprazole sodium
- Chinese alias: 2-{[4- (3-
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- [Drug name]
Rabeprazole sodium pharmacology and toxicology
- Rabeprazole sodium is a new type of proton pump inhibitor, which can be used in the treatment of acid-related diseases, such as pingping, with less effect; it has selective and strong inhibition of Helicobacter pylori (HP). In a double-blind crossover trial in Switzerland, HP-negative asymptomatic patients received placebo, rabeprazole sodium 20 mg, omeprazole (multi-unit tablet system) 20 mg, omeprazole capsule 20 mg, or Lansoprazole 30mg treatment. In the treatment of d1, the effect of the rabeprazole sodium group was significantly better than that of the other test groups, and its median pH was about 3.5. It shows that compared with other proton pump inhibitors, rabeprazole has a significant acid suppression effect within 24 hours of administration.
- In a Japanese study, patients receiving rabeprazole sodium 10mg (n = 48) akg 20mg (n = 27), other pump inhibitors (n = 31), or H2 receptor blockers For patients with ulcers, the symptoms of each group were compared after one week of treatment. The results show that after 3 days of treatment, rabeprazole sodium has a more significant ability to relieve symptoms than other proton pump inhibitors or H2 receptor blockers.
- 137 patients with peptic ulcer (including 102 patients with duodenal ulcer and 35 patients with gastric ulcer) were randomized and controlled. Divided into rabeprazole sodium group 10mg, po, qd and omeprazole group 20mg, po, qd. The treatment time was 4 weeks for duodenal ulcer and 6 weeks for gastric ulcer.
- The results showed that for patients with duodenal ulcers and gastric ulcers, the pain symptoms significantly improved and the pain time disappeared after treatment with this product, which was not statistically different from the omeprazole group. Throughout the trial, adverse reactions occurred in 3 patients in the rabeprazole sodium group, with an adverse reaction rate of 4.29% and an adverse reaction rate of 4.48% in the omeprazole group. The adverse reactions of this product were slight, and the patient did not withdraw from the trial because of adverse reactions.
Pharmacokinetics of Rabeprazole Sodium
- Healthy volunteers po10 80mg · d-1, qd for 7 consecutive days. Cmax (peak concentration) and AUC (area under the curve) increase with increasing dose, and the plasma half-life is approximately 1 h and is independent of dose. The clearance of rabeprazole sodium is 4.37 to 8.40 mL · min-1 · kg-1. The plasma protein binding rate is 96.3%, and about 30% of the drug is excreted from the urine in the form of thiocarboxylic acid and glucuronide derivatives. This product is metabolized by the cytochrome P450 enzyme system, and the bioavailability is not affected by food or antacids.
Rabeprazole sodium indication
- It is used to treat acid-related diseases, such as peptic ulcer, gastroesophageal reflux disease, and Zhuo-Ellison syndrome.
Rabeprazole sodium adverse reactions
- The main adverse reactions were rash, constipation, diarrhea, headache, ALT, AST, ALP, -GTP, LDH, and elevated total bilirubin. Disappeared after stopping the medicine.
Rabeprazole sodium interaction
- This product does not affect the clearance of diazepam, phenytoin, warfarin, theophylline; the combination of this product with digoxin or ketoconazole affects the pharmacokinetics of the latter two, because their absorption depends on the acidity of the stomach; thunder Beprazole has no interaction with antacids. Food and time do not affect the bioavailability of rabeprazole sodium.
Rabeprazole sodium dosage
- The adult dose is 10mg, po, qd. In severe cases, the dose can be increased to 20mg, po, bid.
Rabeprazole sodium precautions
- 1. Prohibited patients who are allergic to this product, benzimidazole derivative or any ingredient in the dosage form.
- 2. Banned for pregnant and lactating women.
- 3. Since this product also has a high effect on the symptoms caused by gastric malignant lesions, the possibility of malignant lesions should be ruled out before using this product.
- 4 Patients with severe hepatitis should be used with caution, starting with a small dose and monitoring liver function.
- 5. Not recommended for children under 12 years of age.
- 6. Elderly patients do not need to adjust the dosage when using this product.