What Is Somatropin?
Growth hormone is DNA recombinant human growth hormone, which has the same effect as human growth hormone. Can promote bone, internal organs and whole body growth. Promote protein synthesis, affect fat and mineral metabolism, and play a key role in human growth and development. Approximately 80% of the subcutaneous injection is absorbed, the blood concentration peaks within 5 hours, and the half-life is 4 hours. 90% of the injected dose is metabolized in the liver, and only about 0.1% is excreted in the original form by the biliary tract and kidneys.
- Western Medicine Name
- Growth hormone (HGH)
- Chinese Medicine Name
- Growth hormone
- English name
- GH, somatropin
- Affiliated Department
- Internal Medicine-Endocrinology
- The main symptoms
- Acromegaly (too much), Dwarfism (too little), Giant disease (too much)
- Main cause
- Growth hormone secretion is abnormal
- Multiple groups
- child
- Secretion site
- pituitary
- Hormonal properties
- Peptide hormone, protein
- Whether synthetic
- Able to synthesize
- Clinical significance
- Anti-aging and promote growth
- Taboo crowd
- Children with closed bones
- Growth hormone is DNA recombinant human growth hormone, which has the same effect as human growth hormone. Can promote bone, internal organs and whole body growth. Promote protein synthesis, affect fat and mineral metabolism, and play a key role in human growth and development. Approximately 80% of the subcutaneous injection is absorbed, the blood concentration peaks within 5 hours, and the half-life is 4 hours. 90% of the injected dose is metabolized in the liver, and only about 0.1% is excreted in the original form by the biliary tract and kidneys.
Growth hormone secretion and mechanism of action:
- The general term for all kinds of hormones that can regulate and control the endocrine mechanism of animals, so that the nutrients entering the body can be redistributed in a beneficial direction according to human growth requirements for animals. Hormones only regulate (increase or decrease) the speed of certain physiological reactions, but they cannot provide the energy of the reaction process itself, nor can they start new metabolic reactions. Therefore, when the original response is excessively stimulated, it is as harmful as when the hormone is deficient. In the past, thiouracil, iodinated protein, and ethinylestradiol were used as feed growth hormone for additives, but soon it was found to have side effects and was banned. The growth hormone currently used as a feed additive, with a molecular weight of about 22000, is a pituitary hormone. It is a single-chain polypeptide molecule composed of 191 amino acids in a certain order and can be extracted from the pituitary. It can also be produced by recombinant DNA technology. Growth hormone acts on the entire body, and has effects on protein synthesis, glucose metabolism, regulating renal function (glomerular filtration rate) and water metabolism, and increasing the permeability of cells to amino acids, so it can promote the body (bone, muscle and Organs). This hormone has interspecific specificity. The growth hormone present in cattle is only effective for cattle. It is not only used to promote growth but also has adverse effects. When taken orally, this hormone is destroyed by digestive enzymes, broken down into amino acids and rendered ineffective. Often the entire protein molecule is not used, but as long as 38 to 40 amino acid fragments, even smaller peptides are active, they can promote the growth of young animals and prevent dwarfism caused by small growth hormone secretion; for animals with raw milk tissue May increase lactation. In addition, research on growth hormone for pigs has also progressed. Injection into piglets can promote growth and increase lean meat. The mechanism of action of hormones is very different from that of general feed additives. Therefore, it is difficult to judge the overall advantages and disadvantages of general feeding tests and metabolic tests, and it needs to be comprehensively evaluated from the perspectives of endocrinology, toxicology and even genetics. In addition, countries and regions with tight protein resources should also consider their nutritional resource background and actual economic effects. Under low nutrient levels, growth hormone is often difficult to obtain the expected results.