What Is Stanozolol?

The chemical name of stanazol is 17-methyl-2'H-5-androst-2-ene- [3,2-c] pyrazole-17-ol, which is a white crystalline powder; odorless; slightly Hygroscopicity. It is slightly soluble in ethanol or chloroform, slightly soluble in ethyl acetate or acetone, very slightly soluble in benzene, and almost insoluble in water or methanol.
Stanozolol generally refers to stanozolol

Clinically, as anabolic steroids, it has the effects of promoting protein synthesis, inhibiting protein heterogeneity, lowering blood cholesterol and triacylglycerol, promoting calcium and phosphorus deposition, and reducing bone marrow suppression, and can increase physical strength, appetite and weight gain. This product has a strong assimilation effect.

Chinese name: Stanizol
Foreign name: Stanozolol

CAS number: 10418-03-8
Molecular formula: C21H32N2O

Stanozolol compounds

Stanozolol Basic Information

Chinese name: Stanazol

Chinese alias: Stanozolol

English name: stanozolol

English alias: Tevabolin; Stanozolol; Winstrol; STANAZOL; Estazol; Anabol; STANOZOL; Stromba;

CAS number: 10418-03-8

MDL number: MFCD00133084

EINECS number: 233-894-8

RTECS number: BV8741000

PubChem number: 24899733

Molecular formula: C ₂₁ H ₃₂ N ₂ O

Structural formula:

Molecular weight: 328.49200

Exact mass: 328.25100

PSA: 48.91000

LogP: 4.11810

Physicochemical Properties of Stanozolol

Appearance and properties: white to light yellow powder

Density: 1.129 g / cm ³

Melting point: 242ºC

Boiling point: 490.8ºC at 760 mmHg

Flash point: 250.7ºC

Stability: Stable at normal temperatures and pressures.

Storage conditions: 2-8ºC

Vapor pressure: 1.89E-10mmHg at 25 ° C

Stanozol Safety Information

Danger category code: R63

Safety Instructions: 53-22-36 / 37 / 39-36-26

Dangerous goods mark: Xn ^[1]

Stanozolol molecular structure data

1. Molar refractive index: 95.87

2. Molar volume (cm / mol): 290.8

3. Isometric Zhang Rongrong (90.2K): 769.1

4. Surface tension (dyne / cm): 48.8

Stanozolol Computational Chemical Data

1. Reference value for calculation of hydrophobic parameters (XlogP): 4.5

2. Number of hydrogen-bonded donors: 2

3. Number of hydrogen bond acceptors: 2

4. Number of rotatable chemical bonds: 0

5. Topological molecular polar surface area (TPSA): 48.9

6. Number of heavy atoms: 24

7. Surface charge: 0

8. Complexity: 538

9. Number of isotope atoms: 0

10. Determine the number of atomic stereocenters: 7

11. Uncertain number of atomic stereocenters: 0

12. Determine the number of chemical bond stereocenters: 0

13. Uncertain number of chemical bond stereocenters: 0

14. Number of covalent bond units: 1

Stanozolol uses

It is used for chronic wasting diseases, severe illness and frail weight loss after surgery, old and frail, osteoporosis, dysplasia in children, aplastic anemia, etc. ^[2]

Stanozolol Pharmacopoeia Standard

Stanozolol source (name), content (potency)

This product is 17-methyl-2'H-5-androst-2-ene- [3,2-c] pyrazole-17-ol. Calculated on dry basis, containing C21H32N2O shall not be less than 98.0%.

Stanizol traits

This product is white crystalline powder; odorless; slightly hygroscopic.

This product is slightly soluble in ethanol or chloroform, slightly soluble in ethyl acetate or acetone, very slightly soluble in benzene, and almost insoluble in water or methanol.

Specific rotation

Take this product, weigh it accurately, add absolute ethanol to dissolve and quantitatively dilute it to make a solution containing about 20mg per 1ml, and measure it according to the law (Appendix VIE of the second edition of the Pharmacopoeia, 2010 edition). The specific rotation is + 34 ° to + 40 ° .

Stanozolol identification

(1) Take about 2mg of this product, add 3ml of p-dimethylaminobenzaldehyde test solution, it is yellow-green, and inspect it under an ultraviolet light (365nm), showing yellow-green fluorescence.

(2) Take this product, add absolute ethanol to dissolve and dilute it to make a solution containing about 40g per 1ml, and measure according to UV-Vis spectrophotometry (Appendix IVA of Pharmacopoeia Part II of 2010 edition). It has a maximum at a wavelength of 224nm. absorb.

(3) The infrared light absorption spectrum of this product should be the same as that of the control ("Infrared Spectra of Drugs" 597).

Stanozolol test

relative substance

Take this product, add dichloromethane-absolute ethanol (9: 1) to dissolve and dilute to make a solution containing 10mg per 1ml, as the test solution; take an appropriate amount of precision, use dichloromethane-absolute ethanol ( 9: 1) Dilute separately to make a solution containing 10g, 30g, and 50g per 1ml, as a series of control solutions; also take the stanozolol and metronolone reference products, and add dichloromethane-absolute ethanol (9: 1 ) Dissolved and diluted to make a solution containing 10mg of stanozolol and 0.1mg of meandrolone per 1ml, as a reference solution. According to the thin layer chromatography (2010 edition Pharmacopoeia Part II Appendix VB) test, draw 10 l of each of the above five solutions, and point them on the same silica gel G thin layer plate with chloroform-methanol (19: 1) as the developing agent. Expand, dry, spray with 20% sulfuric acid ethanol solution, heat at 100 ° C for 10-15 minutes until the spots are clear, and inspect under UV light (365nm). The reference solution should show two clearly separated spots; if the test solution is marked with impurities, compared with the main spots of the serial control solution, the total amount of impurities should not exceed 2.0%.

Loss on drying

Take this product and dry it at 105 to constant weight, and the weight loss shall not exceed 1.0% (Appendix L of Part Two of the Pharmacopoeia of 2010 Edition).

Residue on ignition

Must not exceed 0.1% (Appendix N of Part Two of the 2010 Pharmacopoeia).

Determination of stanozolol

Take about 0.27g of this dry product, weigh it accurately, add 30ml of glacial acetic acid to dissolve it, let it cool, add 1 drop of crystal violet indicator solution, titrate with perchloric acid titration solution (0.1mol / L) until the solution becomes green And correct the titration results with a blank test. Each 1ml of perchloric acid titration solution (0.1mol / L) is equivalent to 32.85mg of C21H32N2O. ^[3]

Description of Stanozolol- Related Drugs

Stanazol pharmacological action

Stanozolol is a pro-assimilation hormone, which has a strong assimilation effect, 30 times that of methyltestosterone, androgen activity is 1/4 of the latter, and the differentiation index is 120. It can promote body protein synthesis, inhibit tissue protein dissociation and decomposition, reduce blood cholesterol and triacylglycerol, promote calcium and phosphorus deposition and reduce bone marrow suppression, etc., can enhance physical strength, appetite, weight gain, and weak virilization.

Stanozolol pharmacokinetics

Oral is easily absorbed from the gastrointestinal tract, and the plasma half-life is 4 to 5 hours, which is mainly excreted from the urine.

Stanozolol indications

It is used for chronic wasting diseases, osteoporosis, severe illness and frail weight loss after surgery, old and weak, dysplasia in children, aplastic anemia, leukopenia, thrombocytopenia, hyperlipidemia, etc. For old and sick, postpartum weakness. It is also used to prevent and treat adrenal insufficiency caused by long-term use of corticosteroids. ^[4]

Stanozolol contraindications

Severe liver disease, kidney disease, heart disease, hypertension, pregnant women and patients with prostate cancer are prohibited. ^[5]

Stanozolol Usage and Dosage:

1. Adult and adolescent common dose

(1) Prevention and treatment of hereditary angioedema: Orally, start 2mg (1 tablet) once a day, 3 times a day, and women can take 2mg (1 tablet) once a day. Administration should be individualized based on patient response. If the treatment effect is obvious, the dosage can be reduced every 1-3 months until the daily maintenance amount is 2mg (1 tablet). However, during the reduction process, the condition must be closely observed.

(2) For chronic wasting diseases, frail after surgery, long-lasting trauma and other treatments: Orally, 3 times a day, once 2-4mg (1-2 tablets), females should be reduced.

2. Pediatric commonly used amount

For hereditary angioedema. Under 6 years of age, take 1 mg (half tablet) daily orally and apply only during the onset; for 6-12 years of age, take 2 mg (1 tablet) orally daily and apply only during the onset. ^[5]

Stanozolol precautions

1. Patients with gastric ulcer, liver, lung, heart and other insufficiency should be used with caution.

2. Such as long-term use may have liver dysfunction, jaundice and so on.

3. If acne and other virilization reactions occur, the drug should be discontinued. ^[4]

Stanozolol for pregnant and lactating women:

Disable pregnant women.

Stanozolol for children:

Children with caution, precocious and affect growth.

Stanozolol for the elderly:

Easy to cause water and sodium retention, hyperkalemia should be used with caution. ^[5]

Stanozolol adverse reactions

1. Women: Long-term use may cause acne, hairiness, clitoral hypertrophy, amenorrhea, or menstrual disorders.

2. Men: Long-term use may cause acne, reduced sperm, and decreased semen.

3 Liver: GOP, GTP rise, jaundice.

4 Digestive system: nausea, vomiting, indigestion, diarrhea.

5. Electrolyte: water and sodium retention, edema.

6. Skin: rash, flushing of the face. ^[5]

Stanozolol interaction

When combined with adrenocortical hormones, especially mineralocorticoids, it can increase the risk of edema. Combined use of adrenocorticotropic hormone or glucocorticoid can accelerate the production of acne. Androgen and anabolic steroids can reduce the concentration of coagulation factor precursors (due to changes in the synthesis and decomposition of coagulation factor precursors), and increase the affinity of anticoagulants and receptors, which can enhance anticoagulant activity. When combined with biscoumarins or indanedione derivatives, reduce the amount. When combined with hepatotoxic drugs, it can aggravate liver damage, especially for long-term use, and patients with original liver disease.

Equal to barbiturates, carbamazepine, meprobamate, butepine, and rifampicin will reduce estrogen activity. ^[4]

Stanozolol Expert Reviews

According to domestic reports, 56 patients with aplastic anemia were treated with the combination of stanozolol, anisodamine, and polycarbinol (SAP), with an effective rate of 89%, which was significantly faster and had a higher cure and remission rate (52%). There were 18 cases in the stanazol group, 4 cases were relieved, 5 cases were significantly improved, 9 cases were ineffective, and the total effective rate was 50%. Stanzole can enhance the proliferation and differentiation of hematopoietic stem cells. The SAP program is used to target the different pathogenesis of aplastic anemia, and make use of the strengths of each drug to make up for the shortcomings, thereby increasing the efficacy. Stanozolol has a stronger assimilation effect, which is 30 times that of methyltestosterone, androgen activity is 0.25 times that of the latter, and the differentiation index is 120. The side effects of virilization are minimal. Stanozolol has a stronger assimilation effect, which is 30 times that of methyltestosterone, androgen activity is 1/4 of the latter, and the differentiation index is 120. It has the effects of promoting protein synthesis, inhibiting protein heterogeneity, reducing blood cholesterol and triacylglycerol, promoting calcium and phosphorus deposition, and reducing bone marrow suppression. It can enhance physical strength, increase appetite, and gain weight, while virilization, with little adverse reactions. Suitable for aplastic anemia, leukocytopenia, thrombocytopenia, etc. ^[4]

Clinical application of stanozolol

After application of androgens or anabolic hormones to female patients, they can cause virilization, such as hairiness, long beards, thickening of the sound and deep tones, acne, etc. Generally, the symptoms can gradually disappear after stopping the drug. Male patients use this kind of hormone for a long time, the drug may be converted into estrogen in the body, and it may also inhibit the secretion of gonadotropin and cause testicular atrophy and inhibit sperm production; due to the inhibition of endogenous testosterone production, it can cause impotence; long-term application Androgens can severely affect growth and development, such as accelerating epiphyseal closure can continue for several months after drug withdrawal; application of anabolic hormones can lead to obesity.

Sex hormone

The 17 androgens with -methyl have more serious damage to the liver, which mainly interfere with the excretory function of the intrahepatic capillary bile ducts, causing the bile to accumulate in the central capillary bile ducts of the liver lobe, causing cholestatic hepatocyte damage. The clinical manifestations are bile Stagnation hepatitis. Long-term application of androgens may cause liver cancer, prostate cancer and renal cell carcinoma. In addition, because of its retention of water and sodium, it can cause edema. Nephropathy and heart failure patients should be used with caution, pregnant women with prostate cancer are banned.