What Is Terconazole?

Terconazole chemical name is 1- [4-[[((2R, 4S) -2- (2,4-dichlorophenyl) -2- (1,2,4-triazol-1-yl (Methyl) -1,3-dioxolane-4-yl] methoxy] phenyl] -4-propan-2-ylpiperazine, molecular formula C26H31Cl2N5O3, molecular weight 32.46200, density 1.35 g / cm3, melting point It is 126.3ºC, boiling point is 681.8ºC at 760mmHg, flash point is 366.2ºC, refractive index is 1.64, stored in original container in a cool and dark place, and stored at 2-8 ° C.

Chinese name: Terconazole
Foreign name: Terconazole

CAS number: 67915-31-5
Molecular formula: C26H31Cl2N5O3
Molecular weight: 532.46200

Terconazole compounds

Terconazole Basic Information

Chinese name: Teconazole

Chinese alias: 1- [4-[[(2R, 4S) -2- (2,4-dichlorophenyl) -2- (1,2,4-triazol-1-ylmethyl) -1, 3-dioxolane-4-yl] methoxy] phenyl] -4-prop-2-ylpiperazine; traconazole;

English name: Terconazole

English alias: Terconagole; Triaconazole; Fungistat;

CAS number: 67915-31-5

Molecular formula: C ₂₆ H ₃₁ Cl ₂ N ₅ O ₃

Molecular weight: 532.46200

Structural formula:

Exact mass: 531.18000

PSA: 64.88000

LogP: 4.46560 ^[1]

Teconazole physical and chemical properties

Density: 1.35g / cm ³

Melting point: 126.3ºC

Boiling point: 681.8ºC at 760mmHg

Flash point: 366.2ºC

Refractive index: 1.64

Storage conditions: Store in the original container in a cool, dark place. 2-8 ° C ^[1]

Terconazole uses

A broad-spectrum antifungal drug of lipophilic triazole, its mechanism of action is to highly selectively inhibit cytochromease of fungal cells. ^[1]

Teconazole pharmacological action

This product is a triazole antifungal drug with the same mechanism of action as ketoconazole. This product has antibacterial effects against Candida, many epidermal ringworms and other fungi in vitro. It also has antibacterial effect on certain bacteria. But it is not active against vaginal microorganisms such as lactobacillus. ^[2]

Teconazole pharmacokinetics

When administered intravaginally, about 5% to 16% of this product is absorbed, and the absorbed drugs are metabolized by the liver and excreted from feces and urine. ^[2]

Terconazole indication

To be used to treat vaginal candidiasis. Teconazole pharmacological effects: This product is a triazole antifungal drug, the mechanism of action is the same as ketoconazole, this product has antibacterial effects on Candida, many epidermal ringworms and other fungi in vitro. It also has antibacterial effect on certain bacteria. But it is not active against vaginal microorganisms such as lactobacillus. ^[2]

Teconazole Usage and Dosage

A vaginal suppository containing 80mg of this product is applied before bedtime for 3 days, or 0.4% of a vaginal cream 5g is applied for 7 days. ^[2]

Terconazole adverse reactions

Local vaginal administration has a burning and itching sensation. After the vaginal suppository dose is greater than 80mg, Flu syndrome may occur in some patients. The matrix in the vaginal suppository can react with the latex substances such as contraceptive diaphragms. The cream is used alternately. ^[2]

Ticonazole drug dosage form

Vaginal suppositories: Each capsule contains 40mg or 80mg of this product. 2. Vaginal cream: 40mg / 5g. ^[2]

Terconazole contraindications

It is contraindicated in those allergic to terconazole, cetyl alcohol, propylene glycol or 2 (3) -tert-butyl-4-methoxyphenol. ^[2]

Corresponding effects of terconazole drugs

No related information.

Ticonazole expert review

Triazoles antifungal drugs include fluconazole, itraconazole, voriconazole, ticonazole and posaconazole. The first three are already available in China, but itraconazole and voriconazole are very expensive Applications are subject to certain restrictions. They have the same antifungal mechanism. Perrigo Co (PRGO) said on March 21, 2006 that its 80 mg dose of terconazole vaginal suppositories for yeast infections has been licensed for production and marketing by the US Food and Drug Administration. The product is a generic version of the antifungal drug Terazol3 vaginal suppository produced by Ortho-McNeil Pharmaceutical with a dose of 80 mg. Ortho-McNeil is a company owned by Johnson & Johnson (JNJ). ^[2]