What Is the Connection Between Ibuprofen and Kidney Disease?

Ibuprofen tablets, the indications are suitable for: 1. Relief of acute onset or persistent of various chronic arthritis such as rheumatoid arthritis, osteoarthritis, spinal joint disease, gouty arthritis, rheumatoid arthritis, etc. Symptoms of joint swelling and pain, no cause of treatment and the role of disease control. 2. Treatment of non-articular soft tissue rheumatic pain, such as shoulder pain, tenosynovitis, bursitis, myalgia, and post-exercise injury pain. 3. Acute mild to moderate pain such as: after surgery, after trauma, after strain, primary dysmenorrhea, toothache, headache, etc. 4. It has antipyretic effect on the fever of adults and children.

Whether prescription drugs: Non-prescription drugs
Drug Name: Ibuprofen

Drug type: Essential medicines, medicines for health insurance workers
Use classification: Carboxylic acids

Ibuprofen tablets ingredients

The main component is: ibuprofen. Its chemical name is -methyl-4- (2-methylpropyl) phenylacetic acid or isobutylbenzenepropionic acid. The chemical structural formula is:

Its molecular formula is: C ₁₃ H ₁₈ O ₂
The molecular weight is 206.28.

Ibuprofen sheet traits

This product is a sugar-coated or film-coated tablet, which appears white after removing the coating.

Ibuprofen Tablets

This product is an antipyretic and analgesic drug.

Ibuprofen tablets specifications

0.1 g

Ibuprofen tablets dosage

1. Oral doses commonly used by adults.
(1) Anti-rheumatic, 0.4g ~ 0.6g at a time, rheumatoid arthritis 3 to 4 times a day is larger than osteoarthritis (2) Analgesia of mild or moderate pain and dysmenorrhea, 0.2g ~ 0.4g at a time, Once every 4 to 6 hours. The maximum adult dosage is generally 2.4g per day
2. Commonly used in children. Each time according to body weight 5mg / kg ~ 10mg / kg, 3 times a day.

Ibuprofen tablets adverse reactions

1. Gastrointestinal symptoms include indigestion, burning sensation, stomach pain, nausea, and vomiting, which occur in 16% of long-term users. The above symptoms disappear after discontinuation of the drug, and most of those who do not stop taking the drug can also tolerate it. A small number (<1%) had gastric ulcers and gastrointestinal bleeding, and some had perforations due to ulcers.
2. Nervous system symptoms such as headache, drowsiness, dizziness, and tinnitus are rare and occur in 1% to 3% of patients.
3. Renal insufficiency is rare and occurs mostly in patients with underlying renal disease; however, lower extremity swelling may occur in a few users.
4. Other rare symptoms are rash, bronchial asthma attack, elevated liver enzymes, and decreased white blood cells.
5. If there are gastrointestinal bleeding, impaired liver and kidney function, visual impairment, blood abnormalities and allergic reactions during medication, the drug should be discontinued.

Ibuprofen taboo

People who are allergic to aspirin or other non-steroidal anti-inflammatory drugs may have cross-allergic reactions to this product, and those who are allergic to aspirin may also cause bronchospasm. This product is disabled for this patient.

Ibuprofen tablets precautions

1. Used in women in late pregnancy can prolong pregnancy, causing dystocia and prolonged labor. Not suitable for pregnant and lactating women.
2. It has an inhibitory effect on platelet aggregation, which can prolong the bleeding time, but it can disappear after 24 hours of withdrawal.
3. It can increase blood urea nitrogen and serum creatinine content, and decrease creatinine clearance rate.
4. Use with caution when:
(1) Patients with original bronchial asthma can get worse after taking the medicine.
(2) Cardiac insufficiency and hypertension can cause water retention and edema after administration.
(3) Hemophilia or other hemorrhagic diseases (including coagulopathy and platelet dysfunction), prolonged bleeding time and increased bleeding tendency after medication.
(4) Those with a history of gastrointestinal ulcers are prone to gastrointestinal side effects, including new ulcers, when using this product.
(5) Renal insufficiency increased renal adverse reactions after medication, and even caused renal failure.
(6) Blood tests and liver and kidney functions should be regularly checked during long-term medication.

Ibuprofen tablets for pregnant and lactating women

Disable pregnant women.

Ibuprofen tablets drug interactions

1. Drinking alcohol or using it with other non-steroidal anti-inflammatory drugs will increase gastrointestinal side effects and may cause ulcers. Long-term use with acetaminophen can increase toxic and side effects on the kidney.
2. When used together with aspirin or other salicylic acid drugs, the efficacy is not enhanced, and the incidence of gastrointestinal adverse reactions and bleeding tendency increases.
3. When used with anticoagulants such as heparin and dicoumarin and platelet aggregation inhibitors, there is a risk of increased bleeding.
4. When used in combination with furosemide, the sodium-releasing and hypotensive effects of the latter are weakened.
5. When used with verapamil and nifedipine, the blood concentration of this product increases.
6. This product can increase the blood concentration of digoxin. At the same time, pay attention to adjust the dose of digoxin.
7. This product can enhance the effect of anti-diabetic drugs (including oral hypoglycemic drugs).
8. This product can affect the antihypertensive effect of the latter when used with antihypertensive drugs.
9. Probenecid can reduce the excretion of this product, increase blood concentration, thereby increasing toxicity, so the dose of this product should be reduced when used together.
10. This product can reduce the excretion of methotrexate, increase its blood concentration, and even reach toxic levels. Therefore, this product should not be used with medium or large doses of methotrexate.

Pharmacological effects of ibuprofen tablets

This product has analgesic, anti-inflammatory and antipyretic effects. Its mechanism of action reduces prostaglandin synthesis by inhibiting cyclooxygenase, thereby reducing tissue congestion, swelling, and sensitivity to peripheral neuralgia caused by prostaglandins. It acts as an antipyretic through the hypothalamic thermoregulatory center.

Ibuprofen tablets storage

Keep tightly closed.

Ibuprofen tablets packaging

Plastic bottle, 100 tablets / bottle.

Ibuprofen tablets expiration date

36 months

Ibuprofen film implementation standards

"Chinese Pharmacopoeia" 2010 edition two ^[1]