What is the difference between metronidazole and tinidazole?

differences between metronidazole and tinidazole include antimicrobial effect, administration methods and prescribed doses. While both anti -infectious substances treat bacterial and protozoal organisms, they show an effective effect against different organisms. Doctors may prescribe metronidazole and tinidazole for oral use, but metronidazole can also be administered intravenously or locally. Patients usually require higher dosage of tinidazole, but take medication for a shorter time. Studies show that both anti -infectious substances have carcinogenic properties and similar side effects and that both will interact with other drugs. Metronidazole eliminates the bacteroides and Clostridium together with trichomonas . It takes over the cells and undergoes a molecular change that releases free radicals, causing cellular death. After entering the cell, tinidazole breaks and produces nitrites that damage the cell. It also breaks the chains of deoxyribonucleic acid (DNA) of the organism and changes the formation of DNA. A combination of these actionscauses cell death.

The dose of metronidazole depends on the organism requiring treatment. Patients with sexually transmitted organisms require 375 milligrams (mg) twice a day for up to seven days. Systemic bacterial or protozoal infections require 7.5 mg per kilogram (1 kg = 2.2 pounds) of body weight every six hours for up to 10 days. Amebic infections require 750 mg three times a day for 5 to 10 days. In local preparation of gel, milk or ointments, patients generally apply anti -infectious once or twice daily for the prescribed number of days.

patients usually take one oral 2-gram dose of tinidazole daily for up to three days. Directions recommend taking food medicines. Metronidazole and tinidazole interact with alcohol and patients may have abdominal cramps, nausea, vomiting and headaches. The use of warfarin drugs increases the anticoagulant effects of the drug. Using metronidazole and tinidazoleIn phenobarbital or phenytoin, the elimination of anti -infectious drugs in a hurry.

The side effects of metronidazole and tinidazole include nausea, vomiting and diarrhea or constipation. Patients taking medicines can develop a metal taste in the mouth. Drugs also contribute to systemic overgrowth of yeast. Patients may experience allergic reactions with a number of symptoms, including an anaphylaxic skin rash. Both anti-conectives have the potential to cause symptoms of the central nervous system that produce drowsiness, dizziness and fatigue or generalized weakness.

Some patients have cramps in addition to seizures and aseptic meningitis. Other adverse effects include insensitivity and armor from the peripheral nerve damage. Both formulations can adversely affect the liver, causing darkened urine and nausea, along with the discomfort of the joint and muscle.