What Is Vinblastine?
Vinblastine, also known as vinblastine, is an anticancer drug that interferes with protein synthesis extracted from the oleander plant vinca. Its sulfate is commonly used as a white or off-white crystalline powder. It is odorless, hygroscopic, and easily turns yellow when exposed to light or heat. soluble in water.
Basic Information
- Chinese name
- Vinblastine
- Foreign name
- vinblastine
- Drug alias
- Vinblastine
- Molecular formula
- C46H58N4O9
Vinblastine indication
- Mainly effective for malignant lymphoma, chorionic carcinoma and testicular tumors, others are also effective for lung cancer, breast cancer, ovarian cancer and monocyte leukemia.
Clinical application of vinblastine
- Intravenous or intravenous drip: 10mg (or 6mg / m) / time for adults, the maximum amount does not exceed 18.5mg / m; child dose of 10mg / m, the maximum amount does not exceed 12.5mg / m; once a week. The total amount of one course of treatment is 60 80mg.
Vinblastine adverse reactions
- Gastrointestinal reactions, bone marrow suppression, and peripheral neuritis such as numbness of fingertips, pain in the limbs, muscle tremor, disappearance of reflexes, headache, etc. A small number of patients may have orthostatic hypotension, hair loss, and insomnia.
Vinblastine precautions
- Peripheral nervous system toxicity is also common. Blood examination should be performed strictly during medication. Prevent the fluid from leaking out of the blood vessel during injection.
Vincristine contraindications
- Those who are allergic to this product, pregnant and lactating women, those with cachexia, anemia or bone marrow suppression caused by radiotherapy and chemotherapy are contraindicated. Hepatic insufficiency should be used with caution.
Vinblastine drug interactions
- If there are other leukocyte-lowering drugs in this combination chemotherapy regimen, the dosage should be reduced. Used in combination with allopurinol, colchicine or probenecid, vinblastine can increase blood uric acid concentration.
- Note: The above content is only for introduction, the drug use must be carried out by a regular hospital under the guidance of a doctor.