What Should I Know about HGH Injections?

hgh growth hormone is used in the treatment of children with slow growth and severe burns caused by endogenous growth hormone deficiency, chronic renal failure and Turner syndrome.

hgh growth hormone

hgh growth hormone is used in the treatment of children with slow growth and severe burns caused by endogenous growth hormone deficiency, chronic renal failure and Turner syndrome.

Chinese name

hgh growth hormone

Foreign name

Recombinant Human Growth Hormone for Injection

Main ingredients

Recombinant human growth hormone

Character

White lyophilized powder

Subcutaneous or intramuscular injection has the same effect. Subcutaneous injection usually brings higher serum HGH concentration than intramuscular injection, but the concentration of IGF-1 produced is the same.

HGH absorption is usually slow. Plasma HGH concentration usually peaks after 3-5 hours of administration, and the elimination half-life is generally 2-3 hours. HGH is cleared through the liver and kidneys, and is faster in adults than in children. Metabolized HGH is extremely trace.

1. Children with closed bones are disabled

2, disabled patients with symptoms of tumor progression

3. Critical patients such as severe systemic infection are disabled during the acute shock period of the body

1. Patients for clear diagnosis under the guidance of a doctor.

2. Diabetics may need to adjust the dose of anti-diabetic drugs.

3. Patients with growth hormone deficiency caused by brain tumors or patients with a history of intracranial injury must be closely monitored for the possibility of the progression of the underlying disease or recurrence.

4. Simultaneous use of corticosteroids can inhibit the growth-promoting effect of growth hormone, so patients with ACTH deficiency should appropriately adjust the amount of corticosteroids to avoid its inhibitory effect on growth hormone production.

5. A small number of patients may have hypothyroidism during the growth hormone treatment process, which should be corrected in time to avoid affecting the efficacy of growth hormone. This patient should be regularly checked for thyroid function and given thyroid hormone supplements if necessary.

6. Patients with endocrine disorders (including growth hormone deficiency) may be prone to slippage of the femoral head and epiphyseal plateau. Care should be taken to evaluate any claudication during the growth hormone treatment period.

7. Avoid overdose. One injection of excessive growth hormone can cause hypoglycemia, followed by hyperglycemia. Long-term excessive injection may cause symptoms and signs of acromegaly and other reactions related to excessive growth hormone.

8. The injection site should be changed frequently to prevent fat atrophy.

Medication for pregnant and lactating women: Not recommended.

Medication for children: There is no significant difference between children and adults in terms of pharmacology, toxicology and pharmacokinetics of growth hormone, and it can be safely used according to body weight.

Medication for elderly patients: The elderly have no obvious differences with adults in terms of pharmacology, toxicology and pharmacokinetics, and can be used safely.

Growth hormone can cause transient hyperglycemia, which usually returns to normal with the prolonged use of the drug or after stopping the drug. According to foreign reports, 80% of growth hormone users have diabetes and need insulin treatment. Other side effects include menstrual disorders, decreased libido, and impotence. The abuse of growth hormone in sports is immoral and dangerous. For children in development, excess exogenous growth hormone can cause giant disease. About 1% of children with short stature in clinical trials have side effects. Local transient reactions (pain, tingling, swelling, etc.) and fluid retention symptoms (peripheral edema, joint pain, or myalgia) are common in the injection site. Early, but the incidence decreases with the time of medication, and rarely affects daily activities. Long-term injection of recombinant human growth hormone causes antibody production in a small number of patients, and the antibody has low binding capacity, which has no definite clinical significance. However, if the expected growth effect is not achieved, antibodies may be produced, and the antibody binding force exceeding 2mg / L may affect the efficacy. Contraindications: 1. Disable children with closed bones 2. Disable patients with symptoms of tumor progression 3. Critical patients such as severe systemic infections are disabled during acute shock

If you have growth retardation caused by auxin deficiency, you can apply auxin treatment.

Growth hormone, also called human growth hormone (hGH), is a peptide hormone banned in sports and is usually used for the treatment of dwarfism. It has anabolic effect, can increase muscle mass, can also promote human bone growth in childhood and adolescence, and strengthen tendons and enlarge internal organs. The illegal use of growth hormone by athletes is mainly to strengthen muscles and increase strength in order to gain competitive advantages.

Pharmacokinetics According to the literature, subcutaneous or intramuscular injection has the same effect. Subcutaneous injection usually brings higher serum GH concentration than intramuscular injection, but the concentration of IGF-1 produced is the same . GH absorption is usually slow. Plasma GH concentration usually peaks after 3 to 5 hours of administration, and the elimination half-life is generally 2 to 3 hours. GH is cleared through the liver and kidneys, and is faster in adults than in children. Metabolized GH is extremely trace.

Why hgh growth hormone secretion decreases with age:

The role of autologous feedback loop

, When the body's IGF-l decreases, it will send a signal to the pituitary gland, causing it to secrete more hGH. This autologous feedback loop function decreases with age ...

HGH secretion

Regulated by two hormones secreted by Hypothalamus in the hypothalamus of the brain: a) Growth Hormonereleasing Hormone (GHRH): It stimulates hGH secretion. Lifetime concentration is the same. The points of hGH. b) Somatostatin (SKIF): It inhibits secretion and decreases in bands every day. At this time, it is the peak band of hGH secretion.

The dosage for promoting children's growth varies from person to person, the recommended dosage is 0.1-0.15IU / kg body weight / day, once a day, subcutaneous injection, the course of treatment is 3 months to 3 years, or as directed by a doctor.

The recommended dosage for the treatment of severe burns is 0.2-0.4IU / kg body weight / day, once a day, subcutaneous injection. The course of treatment is generally about 2 weeks.