How Do I Become a Clinical Cytogeneticist?

Wu Yan, male, born in December 1925, a medical genetics and cell biologist, a senior member of the Chinese Academy of Sciences, an expert with outstanding national contributions, a doctoral supervisor at the Peking Union Medical College of the Chinese Academy of Medical Sciences, and a researcher at the Cancer Institute of the Cancer Hospital of the Chinese Academy of Medical Sciences .

Wu Yan

(Academician of Chinese Academy of Sciences, Cancer Geneticist)

Wu Yan, male, born in December 1925, a medical genetics and cell biologist, a senior member of the Chinese Academy of Sciences, an expert with outstanding national contributions, a doctoral supervisor at the Peking Union Medical College of the Chinese Academy of Medical Sciences, and a researcher at the Cancer Institute of the Cancer Hospital of the Chinese Academy of Medical Sciences .

He graduated from the Medical College of Tongji University in 1950; received a doctorate in medical science from the Institute of Experimental and Clinical Oncology of the former Moscow Medical Academy of the Soviet Union in 1961; a professor of the Chinese Academy of Medical Sciences, an academician of the Chinese Academy of Sciences, a cell biology and medical geneticist, pioneering China's In the new field of human cytogenetics, the first medical cytogenetics research group was created and the first in China to carry out prenatal diagnosis of congenital malformations. Assistant professor of Tongji University, assistant researcher of Central Epidemiology Institute, assistant researcher of Institute of Experimental Medicine, Chinese Academy of Medical Sciences, doctor of Qinghai Xiaxia Health Center, director of cell biology department, associate researcher and researcher of Cancer Institute of Chinese Academy of Medical Sciences, molecular tumor Director of the State Key Laboratory of Science, Deputy Director of the Biology Department of the Chinese Academy of Sciences, Director of the Life Science Department of the National Natural Science Foundation of China, and researcher of the Institute of Oncology, Chinese Academy of Medical Sciences.

Chinese name

Wu Yan

Country of Citizenship

China

place of birth

Peiping

date of birth

December 1925

Occupation

Teaching researcher

political status

Communist Party of China

Born in December 1925

Cell biology, experimental oncology, human genetics undertake a number of research work such as the national "863" project, tumor research, major projects of the National Natural Science Foundation of China, climbing project (later transferred to the "973" project)

Main achievements: Established China's first cytogenetics research group in 1962, and promoted cytogenetics technology and methods suitable for China to the whole country; In 1974, the Cell Biology Department was established at the Institute of Oncology, Chinese Academy of Medical Sciences, and tumor cell biology experiments were conducted. Research; since 1979, he has advocated gene therapy for tumors and carried out gene therapy research under the funding of the National "863" Program; in 1979, he comprehensively introduced the development and achievements of eugenics, promoted its positive aspects, and promoted China's medical genetics. Development played a driving role; in 1991, he served as the director of the Department of Life Sciences of the National Natural Science Foundation of China and launched the human genome project in China during his term; Hello: NEE-HOW: The Bioresource Finder. Won multiple national awards

The creation, development and major achievements of human and mammalian cytogenetics in China won the second prize of National Science and Technology Progress; the establishment of human fibroblasts and epithelial cells in vitro malignant transformation system "Application in Cancer Research", won the second prize of major medical and scientific and technological achievements of the Ministry of Health. "China's esophageal cancer high-risk area detection and detection of scale prevention strategies", won the Ministry of Health medicine and health science and technology progress third prize. In cooperation with Professor Lu Huilin, he comprehensively introduced the development history and merit of eugenics, which has promoted the development of medical genetics in China. In the research of esophageal cancer, he advocated gene therapy for cancer and made pioneering progress. Published more than 300 papers in Chinese, English and Russian. Wu Yan, Cell Biology, Medical Geneticist. In 1980 he was elected as a member of the Chinese Academy of Sciences, and he was later called an academician. He is one of the founders of medical genetics in China. In 1961, he initiated the research of human cytogenetics and tumor cytogenetics in China and created the first medical genetics research group, which played a positive role in promoting the development of medical genetics in China. In 1983, the genetic etiology of esophageal cancer was first proposed, and a strategy for large-scale prevention through detection of susceptible populations in high-risk areas was first proposed. In 1985, research on gene therapy for malignant tumors was first proposed in China. He was the first master and doctoral tutor. His department is the first batch of post-doctoral mobile stations and the first batch of key disciplines of cell biology of the State Education Commission.

Difficult study

In December 1925, Wu Yi was born in Peiping.

Wu Yan's father

Wu Yan has been weak and sick since childhood. He was ill for a year at the age of 3 and was said to have typhoid fever. When I was in elementary school, in the winter, I always had cough, night sweats, and low fever. It was a medicine jar. When the Anti-Japanese War broke out in 1937, he followed his parents to the rear. In early 1940, he came to Sichuan from Guizhou alone, attended junior high school and high school successively in Hejiang and Yongchuan, and lived on "loan" and "public expenses" of the school. In the autumn of 1940, he contracted malaria. After each outbreak, he asked the school doctor's office for some quinine tablets. At the beginning of 1941, after graduating from junior high school, he suffered from stomach tension due to nervousness. The abdominal pain was like a groan, and he moaned all night, then pulled out a pile of stool like black ink. He thought: All the poison was discharged, and one day later he left for Yongchuan to go to high school. First, take a boat along the Yangtze River to the other side of Jiangjin. In the early morning, hire a picker to pick up the luggage of him and another classmate, walk across the mountains and walk 105 miles to Yongchuan. In addition to the frequent outbreaks of malaria, dysentery has also occurred. In 1943, when Wu Zheng was admitted to Tongji University School of Medicine with the same academic qualifications (half a year in high school), he was 170 cm tall and weighed less than 45 kg. Self-dyeing grass green "Zhongshan suit". No wonder one year later, a friend in the same room told Wu Yan: "When we first saw you, we thought you were almost done, and we never thought we would survive."

Tongji University moved to Yibin, Sichuan

In 1992, the comrades of the Xi'an Education Commission collected Wu Jian's handwritten motto. He wrote the words "The early bird gets the worm." People's Education Press, 1993). Wu Yan said that the reason why it was written in Chinese and English was to express the meaning more completely. The stupid bird first reflects the Chinese cultural tradition: it claims to be "stupid bird" like "vile" and "fool brother", it is more implicit, and does not say where to fly, what to do, let readers think for themselves. People who speak English seem to be more arrogant. They always write "I" in uppercase, and they don't like to implicitly fly early to catch bugs! The contrast between Chinese and English can not only make things clearer, but also compare the differences between Chinese and Western cultures, which may help our young people to go global.

In terms of scholarship, Wu Yan also has a motto, but he doesn't know how to express it. In the first half of 1944, Wu Zheng also studied German at the Freshman College of Tongji University in Lizhuang, Sichuan.

1. Open up a new field of human cytogenetics in China. During his postgraduate study in Moscow in 1958, the first application of modern technology to carry out animal and human tumor cell cloning and chromosome research has attracted the attention and appreciation of older Soviet geneticists and colleagues in the biomedical field. After returning to China in 1961, he initiated the research of human cytogenetics and tumor cytogenetics in China, established a set of peripheral blood lymphocyte culture methods and chromosome technologies based on China's conditions, and extended it to the whole country, and used it for prenatal diagnosis, Clinical diagnosis and biomedical research have laid a foundation and promoted the establishment and development of human and mammalian cytogenetics in China. The creation, development and main achievements of human and mammalian cytogenetics in China, which was hosted from 1961 to 1985, won the 1985 National Science and Technology Progress Award.

2. For the first time, the genetic etiology and scale prevention strategy of high incidence areas of esophageal cancer in China were proposed. Since the 1970s, a lot of systematic research has been conducted in the high-incidence field of esophageal cancer. In the early 1980s, an effective and feasible scale prevention strategy was proposed through the detection of susceptible individuals in the high-incidence area of esophageal cancer. Cytogenetics and molecular genetics methods for individuals. 1979-1991, "The Strategy for Detection and Scale Prevention of Susceptible Populations in High Esophageal Cancer Areas in China", won the third prize of the Ministry of Health Science and Technology Progress.

3. Gene therapy for human diseases is initiated and carried out in China. In the 1970s, "Progress in Medical Genetics" explicitly proposed the possibility of treating defective genes through "genetic engineering". In 1986, under the funding of "863", gene therapy research was carried out, and a cDNA sequence isolated from human cancer cells to inhibit the growth of parental cells and promote their differentiation was developed. "The establishment of human fibroblasts and epithelial cells in vitro malignant transformation system and its application in the study of etiology and canceration", 1978-1986, won the second prize of scientific and technological progress of the Ministry of Health.

Fourth, the use of various channels to the National Science and Technology Commission, the Ministry of Health, the National Natural Science Foundation of China to reflect the importance of launching "China's human genome" major project and its far-reaching significance, and organized the implementation of China's major human genome research projects.

Fifth, to open up the restricted area of eugenics research in China. In 1979, he gave a report on "On Eugenics" at the first report meeting of human and medical genetics of the Chinese Genetics Society. The meaning, history, and purpose of eugenics were introduced in a simple way in light of China's population status, and research on eugenics and eugenics was advocated to make it a component part of the implementation of China's national family planning policy. Published more than 10 papers.