How Do I Choose the Best Pharmacology Program?

The use of Chinese medicine has been used for thousands of years. The word "pharmacology" of Chinese medicine has appeared in ancient Chinese medicine books. For example, in the "Sheng Ji Jing" of the Song Dynasty, there is "Pharmacology", but it is researched using modern scientific methods. The role of traditional Chinese medicine has only begun in the 1920s, and experimental pharmacology has been used to conduct traditional Chinese medicine pharmacological research.

Chinese medicine pharmacology

The use of Chinese medicine has been used for thousands of years. The word "pharmacology" of Chinese medicine has appeared in ancient Chinese medicine books. For example, in the "Sheng Ji Jing" of the Song Dynasty, there is "Pharmacology", but it is researched using modern scientific methods. The role of traditional Chinese medicine has only begun in the 1920s, and experimental pharmacology has been used to conduct traditional Chinese medicine pharmacological research.

Chinese name

Chinese medicine pharmacology

Started

Construction of standardized Chinese medicine pharmacology laboratory

issuing time

year 1996

Entering the 21st century, the research of traditional Chinese medicine pharmacology has entered a brand-new period. The construction of standardized pharmacology laboratories has been vigorously strengthened in various places.

Traditional Chinese medicine pharmacology research mainly includes main pharmacodynamic research and general pharmacology research.

Major pharmacodynamic studies

The main pharmacodynamic research of new traditional Chinese medicine should follow the theory of traditional Chinese medicine, use modern scientific methods, formulate experimental plans with characteristics of traditional Chinese medicine, and select or establish animals that are consistent with or similar to traditional Chinese medicine "symptoms" or "disease" according to the functions of new medicine Models and test methods make scientific evaluations of the effectiveness of new drugs. The main pharmacodynamic studies include the following aspects.

Traditional Chinese Pharmacology (1) Design basis and requirements for main pharmacodynamic studies

Traditional Chinese medicine has the characteristics of complex ingredients and extensive pharmacological effects. In the design of experiments, it should be based on the new drug's indication (sickness or syndrome), refer to its function, and select the main drug effect that can reflect the essence of its effect. The test can be selected as appropriate, and the primary and secondary should be distinguished. Such as treating rheumatism syndrome (

In October 2002, eight national ministries and commissions formulated

Methodology of Serum Pharmacology

In the research of traditional Chinese medicine pharmacology by gas chromatography, a considerable part of the pharmacological activity experiments and mechanism of action are performed in vitro, while the crude extracts of traditional Chinese medicine are used for direct in vitro experiments, and the authenticity and reliability of the results are greatly affected. traditional Chinese medicine

As far as synthetic drugs are concerned, the drug factors such as dosage, dosage form and preparation, physiological factors such as age, sex, genetic conditions, pathological factors such as liver and kidney dysfunction, as well as nutritional status and living environment, etc., all have effects on the drug. Significant impact, as is traditional Chinese medicine.

The modernization of traditional Chinese medicine is a process that combines the advantages and characteristics of traditional Chinese medicine with modern science and technology to meet the needs of contemporary social development. The key to the modernization of traditional Chinese medicine is to change ideas. That is, the modernization of academic guiding ideology. Traditional Chinese medicine pharmacology research is not a simple combination of traditional Chinese medicine and pharmacology. Traditional Chinese medicine pharmacology research should be based on the basic theory of traditional Chinese medicine to avoid the problem of westernization of traditional Chinese medicine. The use of traditional Chinese medicine is guided by the theory of traditional Chinese medicine, which has not yet found strong evidence, which has put traditional Chinese medicine in the same situation, that is, on the one hand, it is positive for the clinical efficacy of the disease, and on the other hand, it lacks a strong science. Data to prove it, and its use is limited to experience. Traditional Chinese medicine has four flavors, five flavors, and rises and falls. The properties such as amenorrhea, tonic and diarrhea, and heat-clearing, warming, and qi-charging effects are used to treat the overall evidence of the patient. Western medicine has a clear chemical composition, and its structure and physicochemical properties determine its efficacy. It is used to treat local diseases. disease. In fact, a considerable part of the so-called traditional Chinese medicine pharmacology research was copied from modern western medicine pharmacology research methods. The author believes that the research of traditional Chinese medicine pharmacology in the true sense should have some breakthroughs in the understanding of traditional Chinese medicine theory and traditional theories of qi and five flavors. The guiding ideology and technical means of traditional Chinese medicine pharmacology research must have new ideas and new breakthroughs.

Traditional Chinese medicine pharmacology through the study of traditional Chinese medicine pharmacology should focus on revealing the essence of traditional Chinese medicine's four flavors, five flavors, ups and downs. Starting from clinical practice, the focus of pharmacological research on traditional Chinese medicine should be prescriptions, and the research method should be based on overall research, and a large number of scientific and reasonable animal models of traditional Chinese medicine (syndrome) should be established. The experimental methods, observation indicators and result analysis, judgment marks, etc. are also pharmacological methods that fully comply with the characteristics of traditional Chinese medicine. Based on this, the research on serum pharmacology, compound pharmacokinetics, serum medicinal chemistry, and traditional Chinese medicine chemistry is improved and improved. At the same time, the molecular pharmacology, quantum pharmacology, receptor pharmacology, and ion channels and enzymes of Chinese medicine are actively developed. Pharmacological research in genetics, genetics, etc. combines the whole with high-body tests, combines analysis and synthesis, and combines Chinese and Western medicine to comprehensively and deeply clarify the therapeutic effects of Chinese medicine from multiple aspects and levels. Chinese scholars have made some progress in the substantive research of TCM "syndromes".

As an applied discipline, Chinese medicine pharmacology has an irreplaceable role in the development, research and production of new Chinese medicine. In the process of research on new Chinese medicines in China, pharmacodynamics and toxicology research has become a statutory mandatory research project. One of the basic tasks of the modernization of Chinese medicine is to develop Chinese medicine products with China's independent intellectual property rights that can be in line with the international pharmaceutical market. Its positioning must be "safe, efficient, high-quality, stable, and controllable", of which safety and effectiveness are drugs The most important feature. Pharmacodynamic evaluation was done by the Department of Traditional Chinese Medicine and Pharmacology. China's current drug management law requires that any Chinese medicinal preparation must pass a rigorous efficacy and safety evaluation test before entering a clinical trial. It can be seen that traditional Chinese medicine pharmacology will play a very important role in both the basic theoretical research of traditional Chinese medicine and the study of modernization of traditional Chinese medicine. It is imperative to strengthen basic research on Chinese medicine pharmacology. Using scientific language to clarify the metabolic process, pharmacological action and mechanism of traditional Chinese medicine in the body, this has potential social significance and economic value for the modernization of Chinese medicine and the international market.