What Are Progestin Side Effects?

The effect of progesterone refers to the significant effect of progesterone on women. Progesterone can make the glands in the uterine mucosa grow at the end of the menstrual cycle. Together with estrogen, it can promote the full development of the breast, close the cervix, and reduce mucus Thickens, making it difficult for sperm to penetrate.

The role of progesterone

Progesterone has a significant effect on women. There are still some women who do not know much about the effect of progesterone. Now we introduce the pharmacological effects of progesterone.

In the later period of the menstrual cycle, the glands in the uterine mucosa will grow, the uterus will be congested, and the endometrium will be thickened to prepare for fertilized egg implantation. After the fertilized egg is implanted, it produces a placenta, reduces the excitability of the pregnant uterus, inhibits its activity, and allows the fetus to grow safely.

Together with estrogen, it can promote the full development of breasts and prepare for milk production.

The cervix is closed, the mucus is reduced and thickened, making it difficult for sperm to penetrate; at high doses, the negative feedback to the hypothalamus is used to inhibit the secretion of pituitary gonadotropin and inhibit ovulation. Clinically, it is mainly used for habitual abortion, dysmenorrhea, excessive menstrual blood or hemorrhagic disorder, and amenorrhea.

Large oral doses are also used for diseases caused by progesterone deficiency, such as premenstrual syndrome, menstrual disorders due to ovulation stop, benign breast disease, premenopause and menopause. Vaginal administration can replace oral administration, especially for patients with liver disease.

Some women go to the hospital for examinations, and doctors will say that progesterone (progesterone is mainly produced by the corpus luteum, so it is also called progesterone) is low. But many women don't know the reason, the reasons for low progesterone are introduced below. Low progesterone refers to corpus luteum insufficiency, insufficient progesterone secretion by the corpus luteum, or premature luteal recession, resulting in poor endometrial secretion, which leads to difficulty in implantation of pregnant eggs or abortion of early pregnancy.

Lutein dysfunction may be related to insufficient pituitary secretion of LH, FSH or excessive and low pituitary prolactin secretion; some are due to immature pregnancy eggs and are not sensitive to gonadotropins; some are inadequate ability of the corpus luteum to synthesize progestin, or The proportion of estrogen and progesterone is not coordinated and other factors. Estrogen and progesterone are mainly produced by follicles and corpus luteum, and their main role is to stimulate the development and growth of external genitalia, vagina, fallopian tubes and uterus of adolescent women, and stimulate the emergence of secondary sexual characteristics in women. It can affect metabolic function and promote the development and growth of adolescence.

Progestins usually have their effects on the basis of estrogen. They prepare for fertilized eggs to be planted in the uterus and ensure pregnancy. For example, the endometrium is transferred from the growth phase to the secretion phase, so that the embryo can implant. And it can make the uterus less prone to excitement and ensure that the embryo has a "quiet" environment.

Progesterone mainly acts on the endometrium and uterine muscles, adapts to the implantation of pregnant eggs and maintains pregnancy. Because the content of progesterone receptors is regulated by estrogen, most of the effects of progesterone must be based on the effect of estrogen. Play.

Can progesterone cure irregular menstruation?

Irregular menstruation, which is a problem that many women will encounter, and often worry about it, because it will cause a lot of damage to women's body and spirit. Many women know that progesterone can treat irregular menstruation. Progesterone has a certain effect on artificially adjusting the menstrual cycle, but it must be used with caution. There are many reasons for delayed menstruation. This hormone is not a panacea, and its abuse will adversely affect the human body.

In clinically encountered menopausal women, as long as it is not caused by elevated prolactin, progesterone is generally given for experimental treatment first. After using progesterone, if menstruation comes, it means that there is insufficient progesterone and can continue to be used; if menstruation does not come, it may be amenorrhea caused by other reasons, including mental stimulation, weight loss, excessive exercise, pituitary tumors, ovaries Premature aging, endometrial damage, etc.

Therefore, when the diagnosis is not clear, do not diagnose it blindly. In the case of unclear diagnosis, blind and long-term use is wrong. In addition, as a hormonal drug, progesterone also has certain side effects, which may cause weight gain, sodium water retention, etc., and severe edema may occur. It should be emphasized that if menopause is caused by pregnancy, women may eat unwittingly without knowing it, which may have adverse effects on the fetus.

Progesterone in women can also be called progesterone, which is a necessary introduction to the body. It is an essential element for maintaining female development. So what are the symptoms if progesterone is low? In order to let everyone have a clear understanding. The following mom encyclopedia will introduce to you.

In general, if female friends have low progesterone, they usually show infertility. The symptoms of low progesterone include: depression, physical thyroid insufficiency, or weight gain and fibrocystic Breasts, women's menstrual cycle begins irregularly, or blood clots appear during menstruation, severe breast tenderness and so on. These are the main manifestations of low progesterone in women.

What are the symptoms of low progesterone? In addition to the above several cases of low progesterone in women, it is still particularly prone to miscarriage or premature birth, and even severe stillbirths. This is because a high concentration of progesterone not only has an enlarged effect on a woman's uterus, but also has a good sedative effect on general labor, which can effectively help women maintain early pregnancy.

For the treatment of luteal insufficiency, western medicine generally adopts drug hormones for treatment. The following introduces several western medicine hormone drugs for the treatment of luteal insufficiency.

First, supplement progesterone. If it is determined that the progesterone level of the female in the luteal phase is low and the endometrium is poorly secreted, progesterone supplementation can be used for replacement therapy. This is one of the treatments for luteal dysfunction. There are many choices of medication methods. Progesterone vaginal suppository, intramuscular injection of progesterone, and oral progesterone can achieve corresponding treatment effects.

Second, using chorionic gonadotropin when follicular development is near maturity, using chorionic gonadotropin can induce ovulation, and using chorionic gonadotropin after ovulation can stimulate luteal development, support luteal function, increase progesterone synthesis, Extend luteal life.

Third, for infertile patients with corpus luteum insufficiency, those with elevated serum prolactin can be treated with bromocriptine. 2.5 mg 1-2 times a day, which is also a treatment for luteal insufficiency.

Warm reminder: Many patients use hormonal drugs to treat luteal insufficiency, the clinical effect is not obvious, and one to two months after withdrawal, adverse symptoms appear, menstrual dripping, the uterine mouth cannot be closed, causing endometritis, so treatment should be paid attention to effect.