What Does It Mean if I'm HPV Negative?

Human papillomavirus (HPV) is the main cause of cervical cancer. The pathogenesis of cervical cancer is closely related to the integration of HPV genome. HPV gene components are composed of three parts: early gene region (E), late gene region (L), and long regulatory region (LCR). E6 and E7 in the early gene region (E) are oncogenes, and the encoded oncoproteins are important factors that cause cervical epithelial canceration. The binding and regulation of these two proteins with two major tumor suppressor proteins p53 and pRb in the cell can be significantly changed The cell growth cycle and DNA repair, resulting in genomic instability, are necessary conditions for cell transformation and immortalization.