What Is Anti-Streptolysin O?

[Streptococcus hemolysin O] One of the metabolites of group A streptococci can lyse human red blood cells and has a strong antigenicity.

Anti-streptolysin "O"

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[Method] Commonly used for fast

ASO measurement is very valuable for the diagnosis of group A streptococcus infection, and its presence and content can reflect the severity of the infection.

One week after streptococcal infection in group A, ASO starts to rise, peaks in 4 to 6 weeks, and can last for several months. When the infection subsides, the ASO value decreases and returns to normal within 6 months. The degree does not decrease, suggesting the possibility of recurrent or chronic infection. Repeated determination of antibody titer is of great significance for diagnosis, and antibody titer gradually decreases, indicating that the disease is alleviated.

ASO significantly increased in rheumatic fever, acute glomerulonephritis, nodular erythema, scarlet fever, and acute tonsillitis.

A small number of patients with hepatitis, connective tissue disease, tuberculosis and multiple myeloma can also increase ASO.

Because people often come in contact with group A streptococci, normal people also have low titer antibodies, usually ml. When the titer is> 200IU / ml, it is considered to have diagnostic value.

The ASO content in the serum of less than 15-20% of healthy people is higher than 200IU / ml. Most newborns have higher levels of ASO than their mothers, but the levels of ASO drop sharply in the weeks after birth. The ASO value of preschool children is usually lower than 100 IU / ml, and then increases with age. The ASO value reaches a peak in school age, and the ASO value decreases in adulthood.

Except for the acute stage, the increase of ASO value is usually not detected in the serum of rheumatoid arthritis patients. Only very low levels of ASO are found in the serum of patients with nephrotic syndrome and antibody deficiency syndrome.