What Is Creatine Phosphokinase?
Creatine Kinase (CK), also known as creatine phosphokinase. Creatine kinase is mainly contained in skeletal muscle, cardiac muscle and smooth muscle, followed by brain tissue, and less in gastrointestinal tract, lung and kidney. Creatine kinase mainly exists in the cytoplasm and mitochondria, and is an important kinase that is directly related to intracellular energy movement, muscle contraction, and ATP regeneration. The measurement of creatine kinase activity can be used for the diagnosis of skeletal muscle disease and myocardial disease.
- Chinese name
- Creatine kinase
- Foreign name
- creatine kinase
- nickname
- Creatine phosphokinase
- Meaning
- For the diagnosis of skeletal muscle disease and myocardial disease
Basic Information
Clinical significance of creatine kinase
- Increase
- (1) Physiological increase: Creatine kinase can be significantly increased after exercise, and the more intense and longer the exercise, the more obvious the increase in creatine kinase. The serum creatine kinase activity of the child and the newborn was higher than normal. Some treatment and diagnostic measures, such as the installation of artificial cardiac pacemakers, electrical shock, radiation therapy, cardiac compression, cardiac catheterization, and urinary system examinations, can increase the serum creatine kinase activity. Men have large muscle capacity and higher serum creatine kinase activity than women. Intramuscular injection of certain drugs (such as anesthetics, analgesics, antibiotics, dexamethasone, etc.) can cause increased serum creatine kinase activity. Oral administration of certain drugs, such as clobetin, can increase serum creatine kinase activity.
- (2) Pathological increase: myocardial infarction, viral myocarditis, dermatomyositis, muscular dystrophy, pericarditis, cerebrovascular accident, etc.
- 2. lower
- Hyperthyroidism.
Reference range of creatine kinase normal value
- Normal reference value of serum creatine kinase: 18.0 198.0U / L.
Creatine kinase considerations
- 1. The test specimen should be serum rather than plasma.
- 2. Avoid hemolysis and minimize intracellular adenylate kinase interference.
- 3. In operation, pay attention to avoid the factors that cause enzyme inactivation, such as heating and light.
- 4. To prevent the loss of carbon dioxide and increase the pH and affect the measurement results.