What is fibrous dysplasia?

6 This scars tissue is stored instead of normal, healthy bone, leading to a gradual weakening of scarred bones. The most commonly affected bones are femur, tibia, pelvis, ribs, humerus upper arm and skull or face bones. The bones that are affected by this disease are susceptible to deformity and have a high risk of cleavage. This genetic mutation causes bone cells to deposit fibrous tissue rather than healthy bones. Unlike many other genetic diseases, this is not hereditary. Instead, the mutation happens spontaneously during the development of the fetus.

This bone disease comes in two forms. In monostotic fibrous dysplasia, only one bone is affected by the deposition of the scar tissue. Approximately 70% of the area of ​​this type. In polyostotic fibrous dysplasia, more bones affect the disease. This form of disease is often associated with McCune-Albighta syndrome, which can lead to skin lesions and early puberty except bone dysplasia.

people with a monostotic form of disease often do not develop any symptoms. When it comes to more bones, symptoms such as bone pain, bone deformity and fractures are likely. These symptoms tend to evolve at the beginning of childhood, often at the age of ten. People with a polyostotic disease can also have trouble walking if thighs, tibia or pelvic bones are involved.

Preliminary diagnosis of fibrous bone dysplasia is usually done on the basis of symptoms such as bone pain and bone fractures. The diagnosis is confirmed by medical imaging tests such as X -rays and MRI scanning. These tests determine the location of sick bones and any bone deformities that could develop.

fibrous dysplasia is a chronic progressive disorder without drug. If someone has a disease but does not show any symptoms, they will undergo regular checks to determine the initial symptoms of bone deformation. There is no in these casesTreatment necessary if the symptoms and symptoms of the disease do not develop.

Treatment of fibrous bone dysplasia includes medicines and surgery. Drugs include pamidronate and Alendronate, available under the Aredia® and Fosamax® brands. These drugs help maintain healthy bone tissue and in some people they can increase bone density. Most people take these drugs orally; They are also available as intravenous injections for people who cannot tolerate oral form due to gastrointestinal irritation.

Surgical treatment involves procedures to repair serious fractures and cracks in the bone, proper bone deformation and stabilize vulnerable bones Skin screws and plates. Internally by fastening bones using metal support structures, bone deformities can also be prevented.