What Is Granuloma Inguinale?

This disease, also known as Dunovan's disease, is a chronic, mildly infectious sexually transmitted disease caused by the bacterium Clostridium granulomatosis, which appears as an oval body in monocytes in infected tissues. It is called Donoyan body, so this disease is also called Donovanosis. It is a chronic infectious disease. It is mainly characterized by proliferative plaques of granulation tissue. The anus and vulva are the most common sites. It forms painless ulcers and can be inoculated by itself.

Basic Information

Also known as

Dunovan disease

English name

granulomainguinale

Visiting department

dermatology

Common locations

Anal, vulva

Common symptoms

Pimples, blisters, pustules, itching

Contagious

Have

way for spreading

Sexual contact

Causes of Inguinal Granuloma

Sexual intercourse is the main route of transmission, and the disease can also be spread by pubic lice.

Clinical manifestations of inguinal granulomas

Epidemiological investigations show that the incubation period of the disease ranges from 8 to 84 days, but most occur 30 days after sexual contact. Mainly manifested as pimples, blisters, pustules in the genital area, often accompanied by itching. An ulcer is formed by rupture or spontaneous ulceration. The surface of the ulcer is soft, with yellow secretions exuding, the surrounding area is slightly red, and the surface is light grayish white or yellow moss with a foul odor. Generally there is no tendency for self-healing. Fixed ulcers form masses, and the tissues on the bottom of the ulcers proliferate, forming granulous bulges. Occurs in male foreskin, coronal sulcus, glans, penis body, penis lacing, and women's labia majora, labia lacing, etc. Women's lesions often start from the labia lacing and develop in a "V" shape along the vulva. Perianal (especially homosexual) and groin can be affected in 10% to 15% of patients. About 6% of patients can spread to non-genital areas and internal organs, such as the neck, nose, mouth, limbs, chest, abdomen, buttocks, intestines, liver, kidney, bone marrow, and joints, through hematogenous or lymphatic routes. Pregnant women are prone to hematogenous dissemination, and delivery can cause cervical lesions to spread upward into the uterus. The secretions of the ulcer face are very contagious and destructive. Because they spread the ulcers along the skin folds or form ulcers on one side, they expand outward in a snake shape. The penis and labia of severe patients can be damaged or even reach Deep tissues can cause severe mixed infections. The disease is very slow, even years, and some of them heal without treatment, but sometimes recur. In some patients, pseudogenous skin disease of the external genitalia may occur due to lymphatic obstruction, and urethra, vagina, anus, etc. may be narrowed due to scars and adhesions. It may also become cancerous and cause external genital mutilation.

Inguinal granuloma diagnosis

For those who have sexual contact with the infected person, the first occurrence of external genital nodules, specific marginal bulges, and beef red painless granulomatous ulcers that appear within 8 to 84 days after sexual life should be considered for this disease. Combined with silver plating Finding Donovan bodies in pathological tissue sections can confirm the diagnosis.

Inguinal granuloma treatment

Treatment is mainly based on the selection of antibiotics for the etiology. Oxytetracycline, tetracycline, and streptomycin are all effective. The general course of treatment is not less than 10 to 15 days, and penicillin is not effective.