What is interleukin-6?
interleukin-6 is a substance produced in response to injury or trauma tissue by specialized white blood cells called T-cells, macrophages and endothelial cells. As the name suggests, this substance is interleukin. However, he also classified as cytokine, which means that he is involved in the transfer of information between cells as a signaling molecule and signaling protein. Interleukin-6 may therefore behave as an anti-inflammatory agent and a pro-inflammatory mediator depending on certain conditions. While Interleukin-6 is naturally produced in the body, it can also be synthesized in the laboratory.
Interleukin-6 is known many other names, including interferon-B2, cytotoxic differentiation factor T-cells and B-cells stimulating factor-2, inter alia. It is also classified as a monomer, which means that it belongs to the group of organic compounds that can connect with similar molecules to forming polymers. Specifically, interleukin-6 monomer 184 amino acid secreted by these specialized cells. To thatUTO edition occurs in one gene location known as 7P21. In fact, its release is triggered by damage to tissue or infections. The receptor site is located on the surface of numerous cells throughout the body. From these places interleukin-6 transports various proteins through three major signal transduction routes: protein kinase C, CAMP/Protein kinase and and release of calcium. Each interleukin-6 molecule performs a specific action depending on the cell that has started its release.
interleukin-6 circulation stimulates the immune system by supporting what is called the acute phase reaction. This process promotes the production and release of the acute phase proteins that act as general antibodies. In particular, the release of C-reactive protein increases phagocytosis, a process by which certain cells surround and neutralize attacking bacteria and other pathogens. This results in an acute phase response such as fever.This is due to increased energy distribution in muscle and greasy tissue, causing body temperature to increase.
interleukin-6 is also known as myokin, a type of cytokine induced by muscle contraction and then released into the bloodstream. This exchange supports a number of biological actions. For one thing, this increases fat schedule. It also improves insulin resistance, resulting in better absorption and use of glucose. Therefore, interleukin-6 therapy may have application in the treatment of certain conditions such as obesity and type II diabetes.
While interleukin-6 is vital for optimal immune functioning, the disadvantage has too many good things. A deteriorated or uncontrolled expression of the Interleukin-6 gene can cause undesirable immune reactions and lead to various disassembly, including autoimmune disorders. For example, patients with rheumatoid arthritis usually have elevated interleukin-6 levels in their synovial tissue. In the fight against this dysfunction, scientists continue to explore different ways inhibit inhibitOutbrink interleukin-6. This includes the development of anti-interleukin-6 receptor antibodies.