What Is Microvascular Disease?
Thrombotic microangiopathy (TMA) is a group of acute clinical syndromes showing microangiopathy hemolytic anemia, thrombocytopenia, and organ involvement due to platelet thrombosis during microcirculation. Microvessels mainly refer to small arteries, capillaries, and small veins. The prominent pathological feature is small vessel endothelial cell disease, which is characterized by endothelial cell swelling and stenosis of the official cavity, and thrombosis can be seen in some small blood vessels. Although the pathological changes of microvessels are consistent, the etiology is diverse and the pathogenesis is different.
Thrombotic microangiopathy
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- Chinese name
- Thrombotic microangiopathy
- Foreign name
- thrombotic microangiopathy
- Abbreviation
- TMA
- Types of
- Acute clinical syndrome
- Thrombotic microangiopathy (TMA) is a group of acute clinical syndromes showing microangiopathy hemolytic anemia, thrombocytopenia, and organ involvement due to platelet thrombosis during microcirculation. Microvessels mainly refer to small arteries, capillaries, and small veins. The prominent pathological feature is small vessel endothelial cell disease, which is characterized by endothelial cell swelling and stenosis of the official cavity. Thrombosis can be seen in some small blood vessels. Although the pathological changes of microvessels are consistent, the etiology is diverse and the pathogenesis is different.
- Classical thrombotic microangiopathy refers to hemolytic uremic syndrome (HUS) and thrombocytopenic purpura (TTP). HUS and TTP are both thrombotic microangiopathies. The difference is that HUS is a child-based disease with more pronounced renal impairment. TTP mainly occurs in adults with more prominent neurological symptoms. Other common causes of thrombotic microangiopathy include malignant hypertension, scleroderma renal crisis, pregnancy-related kidney damage, etc. At present, some people have included antiphospholipid syndrome into the category of thrombotic microangiopathy.