What is sinus histiocytosis?

Sinus histiocytosis is a rare disorder of a person unknown cause, usually marked with swelling of the lymph glands either subcutaneous or in deep tissue. It affects mostly young, especially during the first two decades of life. It is usually benign, although sometimes chronic and, in rare cases, can metastasize to other parts of the body through the blood vessels of the lymphatic system. Since the first time identified in 1969, the effective drug was elusive and most doctors recommend careful clinical observation without any treatment of spontaneous self -confidence. Lymph nodes. Lymph nodes are small hollow bends in the shape of a ball that are distributed throughout the immune system of the network body. Inside lymphydutins, immune cells such as histiocytes, act as a filter or a trap for foreign particles and pathogens. Although the lymph node inflammation is relatively common, especially in the fight against infection, the lymph node disorder is called lymphadenopathy.

Sinus histiocytosis with massive lymphadenopathy (SHML) is also called Rosai-Dorfman's disease, named after two cooperating doctors who first described this situation. Most cases occur from birth to 15 years and are manifested as a large but painless enlargement of lymph nodes on both sides of the neck, accompanied by fever and other indicators associated with infection. Biopsy confirms excessive litoral cells, distance sinus channels and an increased number of histiocytes. If there is additional evidence of dermatopathy or a state of aberrant skin, histiocytes have probably escaped by limiting the lymph nodes and being attacking the surrounding skin cells.

Sinus histiocytosis, which has spread to other places than lymph nodes, is described as extraranodal and occurs in about one quarter of all cases. Skin, bone and upper air tract are common targets, but extraanodal metastases can hit anywhere in the body, including central nErvové system, genitourinary system and breast. Treatment and recovery can take years or decades depending on the number of lymph nodes and the type of extraanodal organs affected by SHML. Meanwhile, patients are further threatened by exposing their compromised immune system. Some doctors therefore prefer aggressive therapies for this disease.

Etiology or cause of sinus histiocytosis is not known. The DNA study on criminal histiocytes found no evidence of change, suggesting that the disease is a reactive condition, perhaps in response to an undiscovered virus. The fact that usually follows the atuto theory supports benign clinical course, often with spontaneous resolution and small, if no permanent poor effects at all. On the other hand, especially in extraranodal cases, the disease behaves as opposed to malignant cancer, including the period of exacerbation and remission. Corresponding therapy - surgical excision of lymph nodes, chemotherapy and radiation - had an inconsistent degree of efficiencyi.