What Is Sebaceous Carcinoma?

Sebaceous adenocarcinoma is an adenocarcinoma that points to differentiation of the sebaceous glands, and can be divided into orbital type and extraorbital type. Extraorbital sebaceous adenocarcinoma is generally considered to have a poor prognosis.

Basic Information

English name

sebaceous gland carcinoma

Visiting department

Dermatology; Oncology

Common symptoms

Red nodules or plaques, with ulcers, occasionally pale yellow, with erythema or pearly appearance on the surface of the lesion

Contagious

no

Clinical manifestations of sebaceous adenocarcinoma

There are no obvious clinical signs of skin lesions. Typical skin lesions are red nodules or plaques, ulcers may appear, occasionally light yellow, the surface of the lesions is erythema or pearl-like appearance, and eye skin lesions are easily misdiagnosed as blepitis. Sebaceous adenocarcinoma can occur in patients with Muir-Torre syndrome.

Sebaceous Cancer Test

Histopathological examination of skin lesions showed that the tumor was asymmetric, with unclear boundaries, infiltrating and growing, showing an irregular lobular pattern. The tumor lobes consist of two types of cells, one is basophilic sebaceous germinal cells and the other is sebaceous glands. Cells with cytoplasmic eosinophilic foam. Tumor necrosis is obvious, and abnormal mitotic images are common. Histochemically stained tumor cell epithelial membrane antigen (EMA) was strongly positive and carcinoembryonic antigen (CEA) was negative.

Sebaceous Cancer Treatment

The disease is highly malignant. Not sensitive to radiation therapy. The basic treatment is surgical resection. When localized early, the prognosis is better after surgical resection. Late stage has invaded adjacent tissues and easily relapses after surgery.