What Is Stage III Breast Cancer?
Triple negative breast cancer refers to breast cancer patients who are negative for estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2. According to molecular classification, breast cancer is divided into: luminal type, HER-2 (+) type and Basal-like type. The prognosis of triple-negative breast cancer is not related to tumor size and lymph node status, and the recurrence is relatively rapid. The recurrence peak is 1-3 years, and the incidence of brain metastasis is high.
Triple negative breast cancer
- Chinese name
- Triple negative breast cancer
- Nature
- Breast cancer patients
- Peak of relapse
- 1-3 years
- Features
- High incidence of brain metastases
- Triple negative breast cancer refers to breast cancer patients who are negative for estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2. According to molecular classification, breast cancer is divided into: luminal type, HER-2 (+) type and Basal-like type. The prognosis of triple-negative breast cancer is not related to tumor size and lymph node status, and the recurrence is relatively rapid. The recurrence peak is 1-3 years, and the incidence of brain metastasis is high.
- "Three negative breast cancer" specifically refers to
- The 5-year survival rate of this type of breast cancer is less than 80%. It is more common in young menopausal patients. It has a higher probability of visceral metastasis and brain metastasis, and has a poor pathological grade. p53 mutation, c-kit, p53, and EGFR expression were mostly positive, and basal cell markers CK5 / 6 and CK17 were also mostly positive. Tumors are highly invasive, relatively prone to local recurrence and distant metastasis, and have similar characteristics to basal cell-like breast cancer and breast cancer associated with BRCA1 gene mutations. The prognosis of triple-negative breast cancer is not related to tumor size and lymph node status, and the recurrence is rapid. There is no significant difference in the local recurrence rate. The incidence of distant metastasis is higher than that of non-three-negative breast cancer. High, but the incidence of bone and brain metastases was not significantly different.