What Is the Connection Between Adiponectin and Diabetes?
Adipose tissue is mainly composed of a large number of agglomerated adipocytes. Adiponectin / ADPN is an endogenous biologically active polypeptide or protein secreted by adipocytes. Adiponectin is an insulin-sensitizing hormone that can improve insulin resistance and arteriosclerosis in mice; studies in humans have found that adiponectin levels can predict type II diabetes And the development of coronary heart disease, and has shown anti-diabetic, anti-atherogenic and inflammatory potential in clinical trials.
- Researchers have discovered a new compound that regulates adiponectin
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- Adiponectin is not only made by
- Kondo et al. Discovered by extensive genome scan
- In October 2009, Elsevier reported that the first randomized double-blind placebo-controlled human trial in humans has shown that astaxanthin can consume human triglycerides and increase high-density lipoprotein HDL and adiponectin. Research Units: Pharmaceutical Laboratory, Kashiwa Hospital, Tzuhui University, Chiba, Japan; International Institute of Nutrition and Metabolism, Tzuhui University, Tokyo, Japan.
- BACKGROUND: Astaxanthin has been reported to significantly improve dyslipidemia and metabolic disorders in animals, but the effect of astaxanthin on human lipids is not well known.
- Methods: The natural astaxanthin dosage was 0, 6, 12, 18 mg / day for 12 weeks, and a placebo control was used. Samples were selected.
- Astaxanthin increases adiponectin
- Results: Before and after the control test, body mass index (BMI) and LDL low-density lipoprotein had no effect at the above doses. However, triglycerides were reduced by 30-50%, and high-density ester protein (HDL) was significantly increased by 20-30%. Multi-sample comparisons showed that triglycerides were significantly reduced by 30-50% in the 12 and 18 mg / day groups, and high density ester protein (HDL) was significantly increased by 20-30% in the 6-12 mg / day dose group. Serum in the 12-18 mg / day dose group Adiponectin increased, and changes in adiponectin were positively correlated with changes in HDL, and were not related to indexes such as age and fitness.
- The upper graph shows that adiponectin increases the most when astaxanthin reaches 12 mg / day. The lower graph shows that HDL also increased significantly with the increase of adiponectin.