What Is the Connection Between Metabolic Syndrome and Obesity?

Metabolic syndrome refers to the pathological state of metabolic disorders of the body's proteins, fats, carbohydrates and other substances. It is a complex set of metabolic disorders and is a risk factor for diabetic cardiovascular and cerebrovascular diseases. It has the following characteristics: a variety of metabolic disorders in one, including obesity, high blood sugar, hypertension, dyslipidemia, high blood viscosity, high uric acid, high fatty liver incidence and hyperinsulinemia. These metabolic disorders are heart, Cerebrovascular disease and the pathological basis of diabetes. It can be seen that diabetes is not an isolated disease but a component of the metabolic syndrome. There is a common pathological basis. At present, it is generally believed that their common cause is insulin resistance and hyperinsulinemia caused by obesity, especially central obesity. can cause increased diseases such as hypertension, coronary heart disease, stroke, and even some cancers, including breast cancer related to sex hormones, endometrial cancer, prostate cancer, and pancreatic cancer, hepatobiliary cancer, and colon of the digestive system Cancer, etc. Having common prevention and treatment measures to prevent and control one type of metabolic disorder is also beneficial to the prevention and control of other metabolic disorders.

Basic Information

English name

metabolicsyndrome

Visiting department

Internal medicine

Common symptoms

Obesity, hyperglycemia, hypertension, dyslipidemia, hyperlipidemia, hyperuricemia, incidence of fatty liver, hyperinsulinemia

Contagious

no

Causes of metabolic syndrome

The etiology of the metabolic syndrome has not yet been clarified. At present, it is believed that it is the result of multiple genes and multiple environmental interactions, and is closely related to heredity and immunity. The disease is affected by a variety of environmental factors, concentrated in the high-fat, high-carbohydrate diet structure, increasing the incidence of insulin resistance, low labor intensity, and less exercise causing the occurrence and development of metabolic syndrome.

Clinical manifestations of metabolic syndrome

1. Abdomen is obese or overweight.

2. Abnormal lipid metabolism.

3. Hypertension.

4. Diabetes, insulin resistance and / or impaired glucose tolerance.

Diagnosis of metabolic syndrome

The diagnostic criteria recommended by the Chinese Medical Association Diabetes Branch:

1. Overweight and / or obese BMI 25.

2. Hyperglycemic fasting blood glucose (FPG) 6.1mmol / L (110mg / dl) and / or 2hPG 7.8mmol / L (140mg / dl), and / or those who have been diagnosed with diabetes and treated.

3. Hypertension systolic / diastolic blood pressure 140 / 90mmHg, and / or have been diagnosed with hypertension and treated.

4. Dyslipidemia Fasting blood triglycerides 1.7mmol / L (150mg / dl), and / or fasting blood HDL-C <0.9mmol / L (35mg / dl) (male), <1.0mmol / L (39mg / dl) (female).

Those with 3 or all of the above 4 components can be diagnosed as metabolic syndrome.

Metabolic Syndrome Treatment

Lose weight

(1) Adjust diet to a reasonable diet, control the total calories and reduce fat intake. For those with 25 BMI 30, a daily low-calorie diet of 1200 kcal (5021 kJ) is given to keep their weight in a proper range.

(2) Appropriate physical activity and physical exercise, and encourage light to moderate physical activity for 30 minutes daily

2. Reduce insulin resistance

In addition to weight loss and exercise, metformin and the insulin sensitizer thiazolidinediones are commonly used in the clinic to increase insulin sensitivity. However, the mechanism of the two in treating metabolic syndrome is very different.

3. Improve blood lipid disorders

The role of lipid-lowering therapy in metabolic syndrome is also important. Common drugs are fibrates and statins.