What Is the Relationship Between Fibrosis and Cirrhosis?

Liver fibrosis is a liver disease with many causes. In clinical practice, viral hepatitis, alcoholic liver, fatty liver, and autoimmune diseases are more common.

Liver fibrosis

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Liver fibrosis is a liver disease with many causes. In clinical practice, viral hepatitis, alcoholic liver,

There are many causes of liver fibrosis, and viral hepatitis, alcoholic liver, fatty liver, and autoimmune diseases are more common in clinical practice.

1. Weakness This is one of the common symptoms of early liver fibrosis.
2. Anorexia is sometimes accompanied by nausea and vomiting.
3. Chronic dyspepsia, abdominal bloating, constipation or diarrhea, latent pain in the liver area, etc. Some patients have no obvious history of chronic liver disease in clinical practice, only after further examination.
4. Chronic gastritis Many patients with chronic hepatitis have symptoms such as acid reflux, belching, hiccups, abdominal pain, and abdominal fullness.
5. Hemorrhagic Chronic Hepatitis Due to the decline of liver function, the synthesis of prothrombin and other coagulation factors, liver fibrosis often appears spider nevus, epistaxis, bleeding gums, purple spots or bleeding spots on the skin and mucous membranes, women often have menstruation many.

Diagnosis of liver fibrosis requires four tests for liver fibrosis. This test is mainly used to check the development status and treatment effect of patients with chronic liver disease, and to measure the important basis of inflammatory activity and fibrosis. The four items of liver fiber mainly include the following four examination indicators:
1. PCIII (type III procollagen)
Reflecting the synthesis of type III collagen in the liver, the serum content is consistent with the degree of liver fibrosis, and is significantly related to the serum -globulin level. PCIII is closely related to the degree of liver fibrosis activity, but it is not specific. PCIII is also elevated during fibrosis of other organs. Slow-lived liver with persistently elevated PCIII indicates that the condition may worsen and progress to cirrhosis, and that PCIII falls to normal can predict remission, indicating that PCIII is not only valuable in the early diagnosis of liver fibrosis, but also in the prognosis of chronic liver disease Judgment also makes sense.
Serum PC levels are closely related to the degree of liver fibrosis lesions, reflecting liver fibrosis and inflammatory activity, which are significantly increased in the early stage, while patients with old liver cirrhosis and some advanced liver cirrhosis and liver atrophy do not necessarily increase serum PC.
2.IV-C (type IV collagen)
In order to constitute the main component of the basement membrane and reflect the basement membrane collagen renewal rate, the increased content can more sensitively reflect the process of liver fibrosis, which is one of the early signs of liver fibrosis.
(1) It appears earliest in liver fibrosis and is suitable for early diagnosis of liver fibrosis.
(2) It can reflect the degree of liver fibrosis, with slow moving liver slow living liver cirrhosis

Anti-hepatic fibrosis treatment mainly includes removing pathogenic factors according to the primary disease, such as anti-hepatitis B, hepatitis C virus treatment, anti-schistosomiasis treatment, alcohol abstinence, etc .; treatment of liver fibrosis itself, such as by inhibiting inflammation Or lipid peroxidation, or inhibit the proliferation of liver stellate cells, and promote collagen degradation.

1. Emotionally stable liver is closely related to mental sentiment. Poor mood, depression, and anger can all affect liver function and accelerate the development of lesions. Establishing a strong will, a cheerful mood, a rejuvenating spirit, and eliminating the burden of thought will help improve the condition.
2. Dynamic and static combined with liver fibrosis compensatory dysfunction, should be absolutely bed rest when complicated with ascites or infection. In the period of full compensation and stable disease, you can do some light work or proper activities and carry out beneficial physical exercises, such as walking, doing aerobics, Taijiquan, and qigong. The amount of activity is measured without feeling fatigue.
3. Overuse of generic drugs from simple and blind, will increase the burden on the liver and is not conducive to liver recovery. Drugs that are harmful to the liver, such as isoniazid and barbiturates, should be used with caution or taboo.
4. Quit smoking and alcohol can help fire and blood, long-term drinking, especially hard alcohol, can lead to alcoholic liver cirrhosis. Therefore, drinking can make patients with liver cirrhosis worse and easily cause bleeding. Long-term smoking is not conducive to the stability and recovery of liver disease, can speed up the process of liver cirrhosis, and may promote the risk of liver cancer.
5. Diet adjustment should be low-fat, high-protein, high-vitamin and easy-to-digest diet. Be timed, quantitative, and controlled. In the early days, you can eat more soy products, fruits, fresh vegetables, and appropriate intake of sugars, eggs, fish, and lean meat. When liver function is significantly reduced and there are signs of hepatic coma, protein intake should be properly controlled, and a low-salt diet or taboo should be promoted. Salt diet. The daily intake of salt should not exceed 1 to 1.5 grams, and the amount of drinking water should be within 2000 milliliters. In severe ascites, the intake of salt should be controlled within 500 milligrams and the water intake should be within 1000 milliliters. Spicy spicy products and hard cold foods should be avoided. Overheated foods should not be eaten to prevent blood from coming out.

Cirrhosis is a consequence of the progressive degeneration of the liver caused by different causes.
We must attach importance to the prevention and treatment of various primary diseases, actively prevent and treat chronic hepatitis, schistosomiasis, and gastrointestinal infections, avoid exposure to and use of substances that are toxic to the liver, and reduce pathogenic factors.

What are the pathological causes of liver fibrosis?

1.During liver fibrosis, liver damage can lead to a large amount of lipid peroxidation products overflowing, and cytokines such as transforming growth factor (TGF) can be produced at the same time when HSC is activated; functional substrates under normal liver sinusoidal endothelium Membrane (type IV collagen and LN) plays an important role in maintaining HSC quiescence. Once the basement membrane is destroyed, HSC is activated and transformed into myofibroblasts (MFB), which express a large number of muscular backbone proteins such as smooth muscle actin ( -SMA) plays an important role, and HSC activation is the central link in the occurrence of liver fibrosis.
2. Under the initiation of hepatocyte injury and necrosis, sinusoidal endothelial cells, hepatocyte Kupffer cells and HSCs are involved in liver fibrogenesis, especially Kupffer cells play an important role in initial activation.
3. HSC is the main source of various ECMs. ^[2]