What Is Tissue Hypoxia?
Tissue hypoxia
Tissue hypoxia
Right!- Tissue hypoxia
- Tissue hypoxia
- Cause
- Tissue poisoning Many poisons such as cyanide, hydrogen sulfide, and phosphorus can cause toxic hypoxia in the tissue. The most typical is cyanide poisoning. Various cyanides (such as HCN, KCN, NaCN, NH4CN, etc.) can enter the body through the digestive tract, respiratory tract, or skin, and quickly combine with the trivalent iron of oxidized cytochrome oxidase into cyanated iron cytochrome oxidase, making it Can not be reduced to reduced cytochrome oxidase, so that the respiratory chain is interrupted, and the tissue cannot use oxygen. 0.06g of HCN can cause death. In addition, bacterial toxins, radiation, etc. may damage the mitochondrial respiratory function and cause impaired use of oxygen.
- Vitamin deficiency Certain vitamins such as riboflavin, nicotinamide and nicotinic acid are components of many dehydrogenase coenzymes in the respiratory chain. When these vitamins are severely deficient, the biological oxidation process cannot proceed normally.
- 2. Features
- Arterial blood oxygen partial pressure, blood oxygen capacity, blood oxygen content, and blood oxygen saturation are generally normal. Because the tissue cannot utilize oxygen, the venous blood oxygen content and blood oxygen partial pressure are higher, and the difference between the arteriovenous oxygen content is reduced. Because the amount of oxygenated hemoglobin in capillaries is higher than normal, the patient's skin and mucous membranes are mostly rose red.