Are Diuretics Safe?

Cardiovascular system drugs have a high clinical use rate. To prevent cardiovascular disease, it is necessary to understand the four major risk factors of cardiovascular disease.

Cardiovascular system safe medication

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Cardiovascular system drugs have a high clinical use rate. To prevent cardiovascular disease, it is necessary to understand the four major risk factors of cardiovascular disease.

First, it is high blood pressure. It is very dangerous to stay in a state of high blood pressure for a long time without taking treatment measures. It will cause obvious damage to the patient's heart, brain, kidney, and eyes; Can lead to high blood lipids; three is tobacco and alcohol; four is high blood sugar.

According to figures released by the Ministry of Health, the cardiovascular mortality rate in China has been on the rise in the past 20 years, especially after 2000, and the mortality rate of coronary heart disease among young men aged 35 to 55 has increased the fastest, and In the same period, the mortality rate of coronary heart disease in developed countries is gradually decreasing. Experts believe that the increase in coronary heart disease deaths in China is closely related to the secondary prevention of coronary heart disease (that is, to prevent the recurrence of myocardial infarction in patients with coronary heart disease). The World Heart Federation (WHF) and the Cardiovascular Disease Branch of the Chinese Medical Association jointly conducted The baseline survey conducted by the China Coronary Heart Disease Secondary Prevention Bridge Project confirms this: most patients are not treated reasonably effectively. 60% of patients with acute coronary heart disease in China are treated in secondary hospitals. Due to conditions and levels, more than 80% of secondary hospitals can only treat patients with drug thrombolysis; the internationally recognized American College of Cardiology The statins, aspirin and other effective treatment drugs confirmed in the Guidelines for Secondary Prevention of Heart Disease are not well used.

Hypertension is a cardiovascular disease caused by a variety of etiologies and complex pathogenesis, and its etiology has not been fully elucidated so far. There are 168 million hypertensive patients in China. The common complications of hypertension are stroke, heart disease, diabetes, and kidney disease, which seriously affect the health of our people. Hypertension is a chronic disease and often requires lifelong treatment.

(1) Use a smaller effective dose to obtain the possible effect and minimize adverse reactions, such as unsatisfactory blood pressure reduction, and gradually increase the dose to obtain the best effect;

(2) In order to effectively prevent target organ damage, it is best to use a long-acting drug that can maintain the antihypertensive effect of 24 hours after once-daily administration, and the antihypertensive valley-peak ratio is> 50%;

(3) To achieve the target blood pressure, two or more antihypertensive drugs are often used in combination, or a fixed-dose compound preparation is used.

In August 2002, the United States ACC / AHA / NHLBI jointly issued clinical recommendations on the use of statins and their safety, comprehensively summarizing the issues of reasonable use, precautions, contraindications, and safety monitoring of statins, and the improvement of statins. Correct understanding of the class played an important guiding role;

After 4 years, the National Lipid Association (NLA) statin safety assessment working group published the final conclusions and recommendations of statin safety in the American Journal of Cardiology, as well as a series of special reports, detailed information , Is the latest understanding and progress on the safety of statins.

The NLA Safety Assessment Working Group emphasizes the following 4 adverse reactions: (1) statins and liver function; (2) statins and myotoxicity; (3) statins and renal function; (4) statins and neurological damage. The NLA safety assessment working group recommends four items of monitoring: (1) liver function monitoring; (2) muscle enzyme significance and myopathy prevention; (3) renal function monitoring; (4) nervous system monitoring.