How Effective Is Trazodone for Depression?

Trazodone hydrochloride tablets are suitable for various types of depression.

Drug Name: Trazodone hydrochloride tablets

Drug type: Prescription drugs, medicines for medical workers' injuries
Use classification: Other antidepressants

Trazodone hydrochloride tablet ingredients

The main ingredient of this product is trazodone hydrochloride, chemical name: 2- [3- [4- (3-chlorophenyl) -1-piperazinyl] propyl] -1,2,4-triazolo [4 Molecular structure of 1,3-a] pyridine-3 (2H) -one monohydrochloride:

Molecular formula: C ₁₉ H ₂₂ ClN ₅ O · HCl
Molecular weight: 408.32

Trazodone Hydrochloride Tablet Properties

This product is white or off-white film.

Indications of trazodone hydrochloride tablets

Suitable for all types of depression.

Trazodone hydrochloride tablets specifications

50mg.

Trazodone hydrochloride tablets dosage

Oral, should start from low doses, gradually increase, and pay attention to clinical response and tolerability. If drowsiness occurs, most of the daily dose must be taken before bedtime or reduced. Under normal circumstances, this product should be taken immediately after meals or snacks. Symptoms are reduced during the first week of treatment and better antidepressant effects are achieved within two weeks. 25% of patients need two to four weeks to achieve better treatment results.
The recommended dosage for adults is 150 mg (3 tablets) per day for the initial dose, and 50 mg (1 tablet, one day) for every three to four days. The maximum dose for outpatients should not exceed 400 mg per day (8 tablets, divided). Inpatients (ie more severely depressed patients). Do not exceed 600 mg per day (12 tablets in divided doses).
Maintenance dose: For longer maintenance treatments, the dose should be kept to a minimum. Once there is sufficient response, the dose can be gradually reduced depending on the response to treatment. It is generally recommended to continue taking the medication for more than a few months.

Adverse reactions of trazodone hydrochloride tablets

1. The most common adverse reaction is sedation, sometimes accompanied by fatigue, agitation, dry mouth, dizziness, and hypotension.
2. There are also reports of rare hematological adverse events abroad, such as leukopenia, thrombocytopenia, and anemia.
3. There have been reports of rare liver damage, including jaundice, and sometimes even severe liver cell damage.

Trazodone hydrochloride taboo

Patients with severe liver dysfunction and allergies to this product are contraindicated.

Precautions for trazodone hydrochloride tablets

1. Use with caution in patients with severe renal dysfunction.
2. Use with caution in patients with severe heart disease.
3. This product may strengthen the effect of alcohol and interact with MAO inhibitors, so it should not be used in combination.
4. The reaction ability may decrease during the use of this product. Avoid driving vehicles and operating important machines.
5. Pay attention to monitor liver function during medication, and once liver damage occurs, the drug should be discontinued.

Trazodone hydrochloride tablets for pregnant and lactating women

Due to lack of experience, this product is not recommended for pregnant and lactating women.

Trazodone hydrochloride tablets for children

For those under 18 years of age, its use effect and safety have not been established.

Trazodone hydrochloride tablets for the elderly

The recommended starting dose for elderly patients is 100 mg / day in divided doses. Adverse reactions should be closely monitored if the dosage exceeds 300 mg.

Trazodone hydrochloride tablets drug interactions

1. Should not be combined with MAO inhibitors.
2. When combined with digoxin or phenytoin, the serum drug concentration of digoxin or phenytoin can be increased, and the blood concentration of the two drugs should be closely monitored when combined use is required.

Trazodone hydrochloride tablets overdose

Dizziness, lethargy, nausea and vomiting may occur after overdose. This product has no special rescue drug. Once an overdose occurs, it should be treated according to the general principles of overdose treatment to ensure symptomatic and supportive treatment.

Pharmacology and toxicology of trazodone hydrochloride tablets

Pharmacological effects Trazodone is an atypical tetracyclic antidepressant. Its antidepressant mechanism is to selectively inhibit the reabsorption of serotonin. At low doses, trazodone is an antagonist of serotonin and at high doses it is an agonist. Trazodone does not enhance the effects of catecholamines or inhibit monoamine oxidase activity. It has a sedative effect and a slight muscle relaxant effect, but has no anticonvulsant activity. Trazodone has no significant effect on the release of prolactin. Trazodone has the same effect on two-way and simple depression, and its antidepressant treatment has the advantages of fast onset and low incidence of anticholinergic and cardiovascular effects.
Toxicological studies General toxicity: Trazodone has 150-800 times lower anticholinergic activity than traditional antidepressants in vitro, and has no anticholinergic activity in mice. Anesthetized dogs given intravenously between 1 and 30 mg / kg of zodone can cause dose-dependent heart rate reduction and blood pressure reduction, but have no significant effect on the intervals of ECG. It may be due to the blocking effect on receptors that hypotension will be generated, and the blocking activity on 1 is 5 times that of 2. Liver injury (acute or chronic) caused by trazodone treatment is a specific response, and the damage mechanism may be related to the immune response.
Reproductive toxicity: When the animal dose is 50 times that of the human dose, congenital malformations and fetal absorption occur. A small amount of trazodone can be secreted through human milk, and its potential impact on nursing infants is unknown.

Pharmacokinetics of trazodone hydrochloride tablets

This product is well absorbed after oral administration and will not be selectively concentrated in any tissue. When this product is taken orally after a meal, food may increase the absorption of the drug, reduce the peak blood concentration, and extend the peak time. When taking this product on an empty stomach, the blood concentration peaks after about 1 hour, and it takes two hours after meals. The excretion of this product is divided into two phases, including the primary phase (half life of 3 to 6 hours) and the slower second phase (half life of 5 to 9 hours). It is not affected by food. The elimination rate of this product in the body varies from person to person. different. In some patients, this product may form accumulation in plasma.

Storage of trazodone hydrochloride tablets

Keep tightly closed.

Packaging of trazodone hydrochloride tablets

Aluminum-plastic packaging, 12 pieces / board.

Validity of trazodone hydrochloride tablets

Tentative 18 months.

Standards for trazodone hydrochloride tablets

State Food and Drug Administration Standard (Trial) YBH02482005 ^[1]