Is it Safe To Take Aspirin and Codeine?

Aspirin and codeine tablets are used for the relief of post-operative pain and moderate cancer pain.

Drug Name: Aspirin codeine

Drug type: prescription
Special medicine: Narcotic Drugs

Aspirin codeine ingredients

This product is a compound preparation, its components are: aspirin: 400mg, codeine phosphate: 8.4mg

Aspirin codeine traits

This product is a white tablet.

Aspirin and codeine indications

It is used to alleviate post-operative pain and moderate cancer pain.

Aspirin codeine usage dosage

Oral, 1-2 tablets for adults, 3 times a day; 2 tablets for moderate cancer pain, 3 times a day.

Aspirin codeine adverse reactions

Common adverse reactions of this compound are: dizziness, constipation, nausea and vomiting, respiratory depression, rash, and angioedema.
1. Aspirin is generally used for antipyretic and analgesic doses and rarely causes adverse reactions. A large number of long-term medications, especially the drug blood concentration of 200ug / ml, are more prone to adverse reactions. include:
Central nervous system: reversible tinnitus, hearing loss, etc.
Gastrointestinal tract: Nausea, vomiting, epigastric discomfort or pain are more common, and they can disappear after stopping the drug. Gastrointestinal bleeding or ulcers may occur after long-term or large doses.
Anaphylaxis: It occurs in 0.2% of patients and manifests asthma, urticaria, angioedema, or shock.
Hepatic and renal impairment: generally related to the size of the dose, and are reversible, can be recovered after stopping the drug. However, there have been reports of necrosis of the kidney.
2. The most common adverse reactions to codeine are drowsiness, dizziness, shortness of breath, nausea, vomiting, abdominal pain, and excitement. More common are headache, excitement, agitation, fatigue, numbness, heavy eyelids, coma, and mental disorders (unbearable excitement or suppression can be seen, especially in elderly patients or debilitated patients).
Autonomic nervous system: dry mouth, hyperhidrosis are common, occasionally blushing, salivation, pupil shrinkage, etc.
Gastrointestinal system: Difficulty swallowing, heartburn, bloating, constipation, etc.
Cardiovascular system: chest pain, palpitations, tachycardia, hypotension, etc. are visible.
Skeletal muscle system: thigh pain, muscle weakness.
Urinary system: polyuria.
Others: pruritus, fever, ear pain, tinnitus, nasal bleeding, euphoria, allergic reactions and drug abuse and addiction (expressed by anorexia, diarrhea, insomnia, anxiety, hallucinations, decreased sexual desire, restlessness, slurred speech, mental disorders , Cramps, unconsciousness, dizziness, etc.).

Aspirin codeine taboo

Disable aspirin or codeine intolerance or allergies.
For severe bleeding, coagulation or hemostatic dysfunction, including hemophilia, hypothrombinemia, hereditary pseudohemophilia, platelet dysfunction, thrombocytopenia, and other inherited platelet dysfunction and vitamin K deficiency and Liver injury is disabled.
anticoagulant therapy is forbidden.
disabled patients with peptic ulcer.
Children and young patients are prohibited when they have chickenpox or flu.

Aspirin codeine precautions

A therapeutic amount of aspirin can cause allergic reactions.
Patients with gastric ulcer, gastrointestinal tract injury, and hematological disease can cause massive bleeding after taking it.
(3) Taking this product before surgery can prolong bleeding time.
Codeine and other anesthetics can increase respiratory depression in patients with head and intracranial injuries, and can cause increased hydraulic pressure in the cerebrospinal spinal cord. It can also cause central nervous system depression. For example, drowsiness can mask patients with head injuries and acute The condition of the abdominal patient leads to misdiagnosis.
This product is likely to be addictive. Avoid long-term or large doses.
Elderly and weak patients with liver and kidney insufficiency, biliary tract disease, respiratory disease, arrhythmia, gastrointestinal inflammation, hypothyroidism, Addison's disease, enlarged prostate, coagulopathy, head injury and acute abdominal pain, urethra Use with caution in patients with stenosis.
Patients who are allergic to salicylic acid and those with asthma should be used with caution.
Those who are engaged in dangerous operations, such as driving and machine operation, should use them with caution, and do not perform the above operations while taking the medicine.
Avoid taking it with ethanol and other CNS inhibitors.
During the medication period, liver, kidney function, platelets, clotting time and prothrombin activation time should be tested regularly.
This product may cause Reye syndrome in children with chickenpox and flu.

Aspirin codeine medication for pregnant and lactating women

There is no data showing the effects of this product on pregnant women. However, aspirin use before pregnancy can cause bleeding in pregnant women, fetuses and newborns. Regular high-dose aspirin six months after pregnancy can prolong pregnancy and childbirth, while aspirin before childbirth can prolong childbirth or cause maternal or newborn bleeding, and codeine may cause respiratory depression in newborns.
Because aspirin and codeine can be excreted in milk, the effect on infants is unclear. It is recommended that lactating women must stop breastfeeding when using this product.

Aspirin and codeine for children

There is no research data on the use of this product in children.

Aspirin and codeine tablets for elderly

Elderly patients are prone to toxic reactions due to the decline of renal function. Please reduce the amount as appropriate. Please refer to other items or follow the doctor's advice.

Aspirin codeine drug interactions

The combined use of tritium and monoamine oxidase can enhance its inhibitory effect.
Co-administration with anticoagulants can increase the risk of bleeding by inhibiting the synthesis of prothrombin in the liver and reducing the combination of anticoagulants and proteins.
(3) Simultaneous administration with 6-mercaptopurine and methotrexate can reduce their binding to protein, increase blood concentration, and enhance toxic reactions such as bone marrow.
Use with antidiabetic drugs and insulin can increase the effect of reducing blood sugar.
Use with penicillin and sulfa can increase the blood concentration of these drugs.
Use with non-steroidal anti-inflammatory drugs, the effect is not enhanced, but it can increase the risk of gastric ulcer and bleeding and the possibility of renal papillary necrosis, kidney cancer, bladder cancer.
Combined with other anesthetic analgesics, ethanol, and general anesthetics, sedatives and central nervous system inhibitors, it can enhance the central nervous system inhibitory effect and make respiratory depression more significant.
Combined with anticholinergic drugs, it can aggravate the adverse reactions of constipation or urinary retention.
Urine basifying drugs (sodium bicarbonate, etc.) and antacids (large-scale long-term application) can increase the excretion of this product from the urine and reduce the blood concentration.
Use with corticosteroids can enhance the anti-inflammatory effect of steroids. As the amount of corticosteroids is reduced or discontinued, aspirin poisoning may occur due to the enhancement of salicylic acid and renal clearance.
When taken with uric acid drugs at the same time, the effect of uric acid drugs can be reduced, and the blood concentration of this product is increased.
Aspirin and p-aminosalicylic acid, furosemide, and vitamin C can cause aspirin and metabolites to accumulate in the body when used together, resulting in poisoning.

Aspirin codeine overdose

Aspirin overdose or poisoning is manifested as: Mild, that is, salicylism, which is more common in rheumatoid patients treated with this product, and manifests as headache, dizziness, tinnitus, deafness, nausea, vomiting, diarrhea, drowsiness, and mental disorders , Sweating, deep breathing, thirst, involuntary movements of hands and feet (most common in the elderly), and visual impairment; Severe, hematuria, convulsions, hallucinations, severe mental disorders, dyspnea and unknown fever, etc .; children Mental and respiratory disorders are more pronounced; laboratory tests may show abnormal EEG, changes in acid-base balance (respiratory alkalosis and metabolic acidosis), hypoglycemia or hyperglycemia, ketonuria, hyponatremia, low Kalemia and proteinuria.
The clinical manifestations of codeine overdose are: dizziness, drowsiness, restlessness, confusion, pupil shrinkage such as needle tips, epilepsy, hypotension, bradycardia, weak breathing, and unconsciousness. Once overdose occurs, the drug should be discontinued immediately and seek medical attention for symptomatic and supportive treatment.

Aspirin and codeine pharmacology and toxicology

Aspirin: Aspirin is a non-steroidal anti-inflammatory drug. Analgesic effect: mainly by inhibiting the synthesis of prostaglandins and other substances (such as bradykinin, histamine) that can make the pain sensitive to mechanical or chemical stimuli, which belongs to peripheral analgesics. However, the possibility of central analgesia (which may act on the hypothalamus) cannot be ruled out. Anti-inflammatory effect: The exact mechanism is not clear. It may be due to the action of this product on inflammatory tissues, which can cause inflammatory reactions by inhibiting prostaglandins or others. The synthesis of substances (such as histamine) plays an anti-inflammatory role. Inhibition of lysosomal enzyme release and leukocyte chemotaxis may also be related to it; Antipyretic effect: It may cause peripheral blood vessel expansion, increase skin blood flow, sweat, and increase heat dissipation by acting on the hypothalamic body temperature regulation center. Antipyretic effect. This central effect may be related to the inhibition of prostaglandin synthesis in the hypothalamus; anti-rheumatic effect: the anti-rheumatic mechanism of this product is mainly anti-inflammatory except for antipyretic and analgesic effects; inhibits platelet aggregation : It works by inhibiting platelet cyclooxygenase and reducing prostaglandin production.
Codeine: Codeine selectively inhibits the cough center of the medulla oblongata, and its antitussive effect is strong and rapid. At the same time, it also acts on the opioid receptors of the central nervous system and produces analgesic effects. Its analgesic effect is about 1/12 to 1/7 of morphine, but it is stronger than general antipyretic analgesics. Can inhibit the secretion of bronchial glands, can make sputum thick and difficult to cough, so it should not be used for patients with thick sputum.

Pharmacokinetics of aspirin and codeine tablets

Aspirin: After aspirin absorption, most of it is hydrolyzed to salicylic acid in the liver. Salicylic acid has a plasma protein binding rate of 65% to 90%. The salicylate binding rate is 65% to 90%. Can be distributed in all tissues of the body, can also penetrate into the joint cavity and cerebrospinal fluid. Salicylic acid is metabolized to a combination of salicylic acid and glucuronic acid, and a small part is oxidized to gentisic acid. Free salicylic acid and bound metabolites are excreted from the kidneys. Excreted faster in alkaline urine; also excreted through milk.
Codeine: Codeine is more easily absorbed by the gastrointestinal tract after oral administration, and is mainly distributed in organs rich in blood flow such as liver and iliac kidney. This product can penetrate the blood-brain barrier and also through the placenta. The plasma protein binding rate is generally 25%, T _1/2 2.9 hours. Elimination is mainly through the kidneys. 90% of the oral dose is excreted by the kidneys within 24 hours, mainly glucuronic acid conjugates (70%), and the rest Excreted by feces. The onset time of analgesic treatment is 30 to 45 minutes after the medication, and it reaches a peak within 2 hours, which can last 4-6 hours.

Aspirin codeine storage

Shaded and sealed.

Aspirin codeine pack

Aluminum plastic packaging, 10 pieces × 1 plate.

Aspirin codeine expiration date

Tentatively 1.5 years ^[1]