What Is Clonal Deletion?

Clonal clearance refers to the TCR of T cell clones that have a high affinity for tissue-specific autoantigens, and at a high concentration, can be deleted by APC when presented by APC.

Clone removal

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Clonal clearance refers to the TCR of T cell clones that have a high affinity for tissue-specific autoantigens, and at a high concentration, can be deleted by APC when presented by APC.

If the TCR of a T cell clone has a low affinity for tissue-specific autoantigens and the concentration is very low, it is not enough to activate the corresponding T cells when presented by APC. Such self-responsive T cell clones coexist with the corresponding tissue antigens. Under normal circumstances It does not cause autoimmune diseases, which is called immunological ignorance.

Clonal clearance is a harmful clone against the self-antigen that lymphocytes are eliminated by negative selection during the development of bone marrow (B cells) or thymus (T cells), and the clone is apoptotic. The latter clone still exists, and is inactivated because it does not receive the signal of the co-stimulatory molecule, so it is not reactive and cannot proliferate; when the MHC-II molecule of the antigen presenting cell is empty, it interacts with T cells, and T cells Will also not be able to propagate, resulting in clone ignore