What Are Glucose Tablets?

Glucosamine hydrochloride tablets, the indication is the treatment and prevention of osteoarthritis in all parts of the body: including knee joint, hip joint, spine, shoulder, hand and wrist, ankle joint, etc.

Glucosamine hydrochloride tablets, the indication is the treatment and prevention of osteoarthritis in all parts of the body: including knee joint, hip joint, spine, shoulder, hand and wrist, ankle joint, etc.

Drug Name

Glucosamine Hydrochloride Tablets

Drug type

Prescription drugs, medicines for medical workers' injuries

Use classification

Other antipyretic, analgesic and anti-inflammatory drugs

Glucosamine Hydrochloride Tablets Ingredients

Chemical name: 2-Amino-2-deoxy-D (+)-glucopyranose hydrochloride Chemical structural formula:

Molecular formula: C ₆ H ₁₃ NO ₅ · HCl
Molecular weight: 215.63

Glucosamine Hydrochloride Tablet Properties

This product is white or off-white film.

Indications of Glucosamine Hydrochloride Tablets

Treatment and prevention of osteoarthritis in all parts of the body: including knee, hip, spine, shoulder, hand and wrist, ankle joint, etc.

Specifications of Glucosamine Hydrochloride Tablets

0.24g.

Glucosamine Hydrochloride Tablets dosage

oral. 240mg 480mg (1 to 2 tablets) at a time, 3 times a day, or as directed by your doctor. Depending on the patient's condition, it can be taken continuously for 4 to 12 weeks, and the medication can be extended if necessary under the guidance of a doctor. Repeat the treatment 2 to 3 times a year.

Adverse reactions of glucosamine hydrochloride tablets

Rarely, mild gastrointestinal discomfort, such as nausea, constipation, bloating, and diarrhea. Some patients may experience allergic reactions, including rashes, itching, and skin erythema.

Glucosamine Hydrochloride Taboo

Patients allergic to glucosamine.

Precautions for Glucosamine Hydrochloride Tablets

No studies have been performed on patients with liver and kidney dysfunction. The drug's toxicity and pharmacokinetic test data do not indicate limitations for these patients. However, patients with severe liver and kidney dysfunction should regularly check liver and kidney function after taking the drug.

Glucosamine hydrochloride tablets for pregnant and lactating women

No adverse effects on reproductive function and lactation have been observed in animal tests. Due to the lack of human studies, pregnant and breastfeeding women should use glucosamine hydrochloride after weighing the pros and cons. Avoid taking the drug for the first 3 months of pregnancy.

Glucosamine hydrochloride tablets for children

No detailed research data is currently available.

Glucosamine hydrochloride tablets for elderly

No special considerations.

Glucosamine Hydrochloride Tablets Drug Interactions

No detailed research data is currently available.

Glucosamine Hydrochloride Tablets Overdose

No detailed research data is currently available.

Glucosamine Hydrochloride Tablets Clinical Trial

This product uses a double-blind, double-simulated, multi-center, randomized controlled clinical study to evaluate its clinical efficacy and safety in the treatment of osteoarthritis. There were 72 cases in the test group and 72 cases in the control group, each dose was 480mg (2 tablets), 3 times a day, the course of treatment was 6 weeks. The research results show that the total clinical effective rate of this product is 80.56%, which can effectively reduce the symptoms of rest pain, joint tenderness, joint swelling, motion pain, morning stiffness and other symptoms caused by osteoarthritis, improve joint activity and reduce blood sedimentation. The results of safety evaluation showed that the incidence of adverse reactions of this product was 8.33%, manifested as fatigue, dizziness, gastrointestinal reactions, and most of them were mild, without special treatment and drug withdrawal.

Pharmacology and Toxicology of Glucosamine Hydrochloride Tablets

Osteoarthritis is the result of abnormal degeneration of articular cartilage proteoglycan biosynthesis. Glucosamine is a natural amino polysaccharide that can stimulate chondrocytes to produce proteoglycans with a normal multimeric structure, inhibit cartilage-damaging enzymes such as collagenase and phospholipase A ₂ , and prevent superoxidative free radicals from harming cells It can delay the pathological process and disease progression of osteoarthritis, improve joint activity and relieve pain.

Pharmacokinetics of Glucosamine Hydrochloride Tablets

Pharmacokinetic tests on glucosamine were performed in rats and dogs using ¹⁴ C-labeled glucosamine. After intravenous administration, glucosamine quickly disappears from the blood and enters a variety of tissues and organs, especially the liver, kidneys, and articular cartilage. In articular cartilage, the radioactivity of labeled glucosamine remains for some time, and its biological half-life is 70 hours. After oral administration, glucosamine is quickly and almost completely absorbed. Its pharmacokinetics and metabolic pathways are consistent with intravenous administration. Human studies using a single dose of labeled glucosamine, intravenous, intramuscular and oral administration have shown that the pharmacokinetic form of glucosamine in humans is consistent with that in animals. With a single oral dose of labeled glucosamine, more than 70% of glucosamine is metabolized due to the first-pass effect of the liver. The gastrointestinal absorption is close to 90%, and only 11% of the radioactivity is excreted from the feces.

Storage of Glucosamine Hydrochloride Tablets

Keep tightly closed.

Packaging of Glucosamine Hydrochloride Tablets

Plastic bottle, 42 tablets / bottle.

Glucosamine Hydrochloride Validity Period

Tentative 24 months.

Glucosamine Hydrochloride Tablets

Trial Standard for Registration of the State Food and Drug Administration YBH17852005 ^[1]