What Are Newborn Eye Drops?

Flumirone eye drops, the indications are inflammatory diseases of the outer and front eye (eyelids, conjunctivitis, keratitis, scleritis, superficial scleritis, iritis, iridocyclitis, uveitis , Postoperative inflammation, etc.).

Drug Name: Flumirone Eye Drops
Drug type: Prescription drugs, topical drugs, medical insurance workers' injuries

Special medicine: Doping
Use classification: Glucocorticoid

Flumirone Eye Drops Ingredients

Chemical Name:
9-fluoro-11, 17-dihydroxy-6-methyl-1,4-pregnadiene-3,20-dione.
Chemical Structure:

Molecular formula: C ₂₂ H ₂₉ FO ₄
Molecular weight: 376.47

Flumirone Eye Drop Properties

This product is a suspension of fine particles. After standing, the fine particles sink and shake to form a uniform milky white suspension.

Indications for Flumirone Eye Drops

Inflammatory diseases of the outer and anterior eyes (eyelids, conjunctivitis, keratitis, scleritis, superficial scleritis, iritis, iridocyclitis, uveitis, postoperative inflammation, etc.).

Flumirone Eye Drop Specifications

5ml: 1mg

Flumirone eye drops usage dosage

Shake well when using, usually 1-2 drops once, 2-4 times a day. Can be increased or decreased according to age and symptoms.

Adverse effects of flemiron eye drops

The literature reported that of a total of 10,343 subjects using flumirone eye drops, 25 cases (0.24%) were found to have adverse reactions. The main adverse reactions were increased IOP in 13 cases (0.13%), ocular irritation or conjunctival hyperemia in 5 cases (0.05%), and ocular lipid in 4 cases (0.04%).
1. Severe adverse reactions (occasional: 0.1% or less, sometimes: 0.1-5%, no specific: 5% or more or unknown) Eyes:
(1) Glaucoma: After several weeks of continuous medication, there may be occasional elevated intraocular pressure or glaucoma. Therefore, regular intraocular pressure examination is required.
(2) Herpetic keratitis, fungal keratitis, and Pseudomonas aeruginosa infection: Sometimes herpes keratitis, fungal keratitis, and Pseudomonas aeruginosa infection are induced. Appropriate measures should be taken in the above situations.
(3) Perforation: used for herpetic keratitis, corneal ulcer or trauma, etc., which may cause perforation.
(4) Cataract under the posterior capsule: When the drug is used for a long period of time, cataract under the posterior capsule sometimes occurs.
2. Other adverse reactions If adverse reactions occur, appropriate measures such as discontinuation of the drug should be taken.

Flumirone Eye Drops Contraindications

Contraindications (the following patients are prohibited to use the drug) patients with a history of allergies to the ingredients of this preparation.
In principle, it is contraindicated (not to be used in principle for the following patients, but should be used carefully when there is a special need)
1) Patients with corneal epithelial detachment or corneal ulcers (possibly exacerbating these diseases. In addition, it may cause corneal perforation)
2) Patients with viral corneal and conjunctival disease, tuberculous eye disease, fungal eye disease, or purulent eye disease (these diseases may be aggravated. In addition, they may cause corneal perforation.)

Precautions for Flumirone Eye Drops

1. Route of administration: Only for eye drops.
2. When administering: In order to prevent contamination of the medicinal solution, care should be taken to prevent the front end of the container from directly contacting the eye when dropping the eye.

Flumirone eye drops for pregnant and lactating women

Avoid long-term, frequent medication for pregnant women or women who may be pregnant. (It is not clear about the safety of medication during pregnancy)

Flumirone eye drops for children

Especially for infants and young children under the age of 2 should be used with caution. (The safety of infants and young children is unknown)

Flumirone eye drops for the elderly

Usually, the physiological function of the elderly is reduced, and attention should be paid.

Flumeron eye drops drug interactions

still uncertain.

Flumeron eye drops overdose

still uncertain.

Flumirone Eye Drops Clinical Trial

This agent is used in 171 cases of external eye diseases (eyelid inflammation, allergic conjunctivitis, vesicular conjunctivitis, spring catarrh, epidemic keratoconjunctivitis, superficial keratitis, herpes keratitis, scleritis, etc.) in the anterior eye The clinical effects of 125 cases of internal diseases (irisitis, iridocyclitis, uveitis, etc.) and postoperative inflammation (cataract, glaucoma, retinal detachment, strabismus correction, etc.) in 134 cases are shown in the following table.

Pharmacology and Toxicology of Flumirone Eye Drops

Pharmacological effects:
Anti-inflammatory effect (rabbit)
Flumirone eye drops exhibited the same inflammation inhibitory effect as dexamethasone eye drops of the same concentration when used in experimental uveitis caused by ferritin or bovine serum protein in rabbits.
Toxicology research:
1. Acute toxicity:
Acute toxicity The acute toxicity of flumirone to rats is 719 mg / kg (male) and 443 mg / kg (female) when administered intraperitoneally. When administered subcutaneously or orally, no animal died even with the maximum technically administrable amount.
2. Subacute toxicity to rats at 0.1 mg / kg and 0.01 mg / kg, once a day for 1 month, adrenal corticosteroid effect appeared. But its degree is only 1/10 of dexamethasone.
3. No eye irritation or eye toxicity was seen in eye drop toxicity, but it had systemic effects of adrenal corticosteroids.

Pharmacokinetics of Flumirone Eye Drops

Eye tissue distribution (Reference: Rabbit)
After the eye drops were administered to rabbits with 25 L of the 0.1% flumirone suspension, the drug concentration in the eye tissues was: corneal 5 minutes later, aqueous humor peaking after 45 minutes, 1.99 g / g and 0.16, respectively g / g. Thirty minutes after eye drops, the drug concentrations in each tissue were: 1.552 g / g of cornea, 0.738 g / g of bulbar conjunctiva, 0.320 g / g of iris, 0.178 g / g of sclera, and 0.154 g / g of aqueous humor. In addition, the disappearance rate of Flumelone from eye tissue was faster than that of Dexamethasone, and Prednisone acetate was faster.

Flumirone eye drops storage

Keep the container tightly closed at room temperature (1-30 ° C). Due to improper storage method, the particles are not easy to be dispersed during shaking, so it needs to be stored upright.

Flumirone Eye Drops Packaging

Plastic eye drop container, 5ml / piece.

Validation of Flumirone Eye Drops

36 months

Flumirone Eye Drops

JX20080019 ^[1]