What Are Possible Concerns with NSAIDs and Surgery?

Non-steroidal anti-inflammatory drugs (NSAIDs) refer to a class of drugs that do not contain glucocorticoids and have anti-inflammatory, antipyretic and analgesic effects. Compared with glucocorticoids, the chemical structure of these drugs lacks the steroid ring of glucocorticoids, but also has antipyretic, analgesic, and anti-inflammatory effects, so they are called non-steroidal anti-inflammatory drugs. . Non-steroidal anti-inflammatory drugs are also first-line drugs for the treatment of osteoarthritis. They are also widely used in other bone and joint diseases, rheumatic immune diseases and pain diseases to reduce pain, stiffness and improve bones and joints of the above diseases. Features.

Basic Information

Nonsteroidal anti-inflammatory pharmacological effects

Antipyretic effect

Lowering the body temperature of those with fever has no effect on normal people. It is related to the inhibition of PG synthesis. It is mainly used for headache, toothache, muscle pain, joint pain, dysmenorrhea, etc. It is not effective for severe pain and smooth muscle colic. Long-term application generally does not produce tolerance and dependence.

2. Analgesic effect

With moderate intensity analgesic effect.

3. Anti-inflammatory and anti-rheumatic effects

This class of drugs has strong anti-inflammatory and anti-rheumatic effects, can alleviate the inflammatory response, control rheumatism and rheumatoid symptoms, but it cannot eradicate the cause, prevent the development of the course of disease and the occurrence of complications. .

Application of non-steroidal anti-inflammatory drugs

NSAIDs have a wide range of clinical uses in rheumatic diseases, and are suitable for various acute and chronic inflammatory joint diseases, adult Still disease, childhood arthritis, various soft tissue rheumatic diseases (muscle fibrosis, tennis elbow, periarthritis, waist Muscle strain, etc.), also used for cancer pain, sports injury and dysmenorrhea. It mainly controls symptoms such as inflammation, pain and fever, but cannot prevent the progress of the disease.

Non-steroidal anti-inflammatory drug adverse reactions

Gastrointestinal tract

Abdominal discomfort, dull pain, nausea, vomiting, fullness, belching, and loss of appetite may occur. A few patients with long-term oral NSAIDs may experience serious complications such as bleeding or perforation.

2. Nervous system

May have headache, dizziness, tinnitus, deafness, amblyopia, drowsiness, insomnia, paresthesia, numbness and so on. Occasionally hyperactivity, excitement, hallucinations, tremors, etc.

3. Blood system

Some patients can cause granulocytopenia, aplastic anemia, and coagulopathy.

4. Allergic reactions

Allergic reactions such as rash, angioedema, and asthma occurred in people with specific constitution.

Notes on non-steroidal anti-inflammatory drugs

People with active peptic ulcer and recent gastrointestinal bleeding, allergic to aspirin or other NSAlDs, people with impaired liver function, people with renal insufficiency, patients with severe hypertension and congestive heart failure, people with reduced blood cells, pregnancy and lactation Women disabled. It is not advisable to drink alcohol during medication, otherwise it will aggravate the gastrointestinal mucosa. Should not be combined with anticoagulants (such as warfarin), it may increase the risk of bleeding.

(Note: The above content is only for introduction, the drug use must be carried out by a regular hospital under the guidance of a doctor.)