What Are the Common Side Effects of Misoprostol?

Diclofenac sodium misoprostol tablets are indicated for the treatment of acute and chronic symptoms and signs of rheumatoid and osteoarthritis. Patients in need of a combination of nonsteroidal anti-inflammatory drugs (NSAID) and misoprostol. Diclofenac Sodium Misoprostol Sodium Diclofenac is used to treat osteoarthritis and rheumatoid arthritis, and misoprostol is used to prevent gastric or duodenal ulcers caused by non-steroidal anti-inflammatory drugs.

Drug Name: Diclofenac sodium misoprostol tablets

Drug type: prescription

Diclofenac sodium misoprostol ingredients

Each tablet of this medicine contains 50 mg of sodium diclofenate, and the outer layer of the enteric-coated tablet core contains 200 & mu; g of misoprostol, and also contains the following excipients: lactose, microcrystalline cellulose, corn starch, polyvinyl pyrrolidone K-30, cellulose acetate phthalate, diethyl phthalate, methyl hydroxypropyl cellulose, cross-linked polyvinyl pyrrolidone, magnesium stearate, hydrogenated castor oil, colloidal anhydrous dihydrate.

Diclofenac Sodium Misoprostol Tablet Properties

Diclofenac sodium misoprostol tablet is a white, round, double-sided convex tablet. One side of the tablet is labeled AAAA and the other is printed with the word SEALEl411.

Diclofenac sodium misoprostol tablets indications

Treats acute and chronic symptoms and signs of rheumatoid and osteoarthritis.
Patients in need of a combination of nonsteroidal anti-inflammatory drugs (NSAID) and misoprostol. The sodium diclofenac in Osk is used to treat osteoarthritis and rheumatoid arthritis, and misoprostol is used to prevent gastric or duodenal ulcers caused by non-steroidal anti-inflammatory drugs.

Diclofenac sodium misoprostol tablets specifications

Tablets 50mgx 10 tablets.

Diclofenac sodium misoprostol tablets dosage

Adults: Take one tablet at a time, with food, 2 to 3 times a day. The tablets should be swallowed whole and not chewed.
Elderly / Liver damage / Kidney damage: The elderly or those with liver damage or mild or moderate kidney damage do not need to adjust the dose because the pharmacokinetics will not cause any clinically relevant changes. However, those with severe liver and kidney damage must be closely monitored.

Diclofenac sodium misoprostol tablets adverse reactions

Gastrointestinal system: abdominal pain, diarrhea, nausea, indigestion, bloating, vomiting, gastritis, constipation, belching. Diarrhea is usually mild to moderate and transient. Oshkok can also reduce diarrhea by taking it with food at the same time, and avoiding the use of magnesium-based antacids.
Liver: Patients with liver disease can cause asymptomatic alanine aminotransferase, alkaline phosphatase, and bilirubin.
Kidney: Common pathological changes caused by non-steroidal anti-inflammatory drugs include: renal papillary necrosis, interstitial nephritis, nephrotic syndrome, and renal failure.
Female reproductive system: Menstruation is frequent. Women before menopause have bleeding and vaginal bleeding during menstruation, and women after menopause may have vaginal bleeding. Other side effects: headache, dizziness, rash. Non-steroidal anti-inflammatory drugs occasionally have an allergic reaction.

Diclofenac Sodium Misoprostol Tabs

Gastrointestinal bleeding is disabled.
Disabled during pregnancy and women planning pregnancy. The drug can increase uterine tension and uterine contraction during pregnancy, can cause miscarriage, and cause premature closure of arterial ducts. Those who are allergic to diclofenac, aspirin and other non-steroidal anti-inflammatory drugs, misoprostol, and other prostaglandins are prohibited from use.

Precautions for Diclofenac Sodium Misoprostol Tablets

Premenopausal women should not use this medicine unless they have effective contraception or are known to be pregnant.
Precaution:
Patients with gastric and duodenal ulcers should be used with caution. If you think it is necessary to use non-steroidal anti-inflammatory drugs, consider using Osc. Compared with sodium diclofenac alone, Oskeel's reports of gastric and duodenal ulcers are significantly lower but occasionally, so Oske should still be used under close observation. Osk, like other nonsteroidal anti-inflammatory drugs, reduces platelet aggregation and prolongs bleeding time. This effect should be considered when examining the bleeding time.
Patients taking non-steroidal anti-inflammatory drugs, including Osker, have fluid retention and edema. Therefore, it is recommended to use it cautiously for damage to heart function and fluid retention. Nonsteroidal anti-inflammatory drugs can cause kidney damage. Use it with caution if the kidney, heart, and liver are damaged. Reduce the dose as much as possible and monitor renal function. All people receiving long-term nonsteroidal anti-inflammatory drugs should be monitored and used as a precautionary measure (such as liver, kidney function, and blood cell count).

Diclofenac sodium misoprostol tablets for pregnant and lactating women

Pregnant women: disabled.
Lactation: Women who are breast-feeding should not take osmog.

Diclofenac sodium misoprostol tablets for children

The safety and effectiveness of children have not yet been determined.

Diclofenac sodium misoprostol tablets drug interactions

Nonsteroidal anti-inflammatory drugs may attenuate the sodium excretion of diuretics by inhibiting the synthesis of prostaglandins in the kidneys. Combined with potassium-preserving diuretics can cause elevated serum potassium levels, therefore, serum potassium needs to be monitored.
Steady-state plasma lithium and digoxin levels can be elevated.
The pharmacokinetic study of diclofenac showed that the drug had no potentiating effect in combination with hypoglycemic agents and anticoagulants. However, interactions with other nonsteroidal anti-inflammatory drugs have been reported. Therefore, monitoring is recommended. Non-steroidal anti-inflammatory drugs combined with methotrexate may cause plasma methotrexate levels to increase and increase its toxicity. Therefore, when using methotrexate, use non-steroidal anti-inflammatory drugs with caution.

Diclofenac sodium misoprostol tablets overdose

The toxic dose of diclofenac sodium misoprostol tablets has not been determined, so there is no experience with drug overdose. Increased drug efficacy may occur when overdose. The acute poisoning of nonsteroidal anti-inflammatory drugs is basically supportive and symptomatic. Reduced absorption by forcing vomiting, gastric lavage and taking activated carbon.

Diclofenac sodium misoprostol tablets pharmacology and toxicology

Diclofenac sodium misoprostol tablet is a non-steroidal anti-inflammatory drug (NSAID) containing a gastric and duodenal mucosal protective agent. Pharmacokinetics: This drug is used once or multiple times. There is no pharmacokinetic interaction between diclofenac sodium and misoprostol. The biological effect of the drug is quite fasting when the two components are used alone. Absorbed completely. After a single oral dose of 50 mg, the peak time was 1-2 hours, and the peak plasma concentration was 1.5 mug / ml. Plasma protein binding rate is above 90%, and the concentration is high in liver, kidney and blood. After the drug enters the synovial fluid of the joint, its clearance speed is slower than in plasma, and the drug concentration of the synovial fluid is higher than the plasma concentration. Diclofenac sodium is mainly metabolized in the liver, and then excreted in the form of glucuronic acid or sulfuric acid conjugate (of which 2/3 are excreted by the kidney and 1/3 are excreted by the bile in the feces). The half-life is 1-2 hours. Age-related pharmacokinetics of diclofenac sodium have not been found. In patients with impaired renal function, a single administration at a regular dose will not cause accumulation. The pharmacokinetics of diclofenac sodium did not change significantly in patients with liver dysfunction. Misoprostol is rapidly absorbed orally and becomes an active metabolite misoprostol after delipidization. This component is easy to detect in plasma, the peak time is about 10 minutes, and the binding rate to plasma protein is less than 90%. Oral misoprostol is excreted in the urine with 80%, and the elimination half-life is 30 minutes. Misoprostol does not affect the cytochrome P450 enzyme system in animal livers. ^[1]