What Are the Different Hyaluronic Acid Benefits?
Hyaluronan, a disaccharide unit composed of D-glucuronic acid and N-acetylglucosamine, also known as uronic acid, hyaluronic acid, the basic structure is composed of two disaccharide units D-glucuronic acid and N-acetyl A large polysaccharide composed of glucosamine. Unlike other mucopolysaccharides, it does not contain sulfur. Its hyaluronic molecule can carry more than 500 times of water, which is recognized as the best moisturizing ingredient today, and is widely used in skin care products and cosmetics.
- Chinese name
- Hyaluronic acid
- English name
- hyaluronic acid
- nickname
- Hyaluronic acid; uronic acid; hyaluronic acid; HA
- Chemical formula
- (C14H21NO11) n
- Molecular weight
- 379.32
- CAS Registry Number
- 9004-61-9
- EINECS registration number
- 232-678-0
- Hyaluronan, a disaccharide unit composed of D-glucuronic acid and N-acetylglucosamine, also known as uronic acid, hyaluronic acid, the basic structure is composed of two disaccharide units D-glucuronic acid and N-acetyl A large polysaccharide composed of glucosamine. Unlike other mucopolysaccharides, it does not contain sulfur. Its hyaluronic molecule can carry more than 500 times of water, which is recognized as the best moisturizing ingredient today, and is widely used in skin care products and cosmetics.
Main ingredients of hyaluronic acid
- Hyaluronic acid is an acidic mucopolysaccharide. In 1934, Meyer et al., A professor of ophthalmology at Columbia University in the United States, first isolated the substance from the bovine vitreous. With its unique molecular structure and physical and chemical properties, hyaluronic acid displays a variety of important physiological functions in the body, such as lubricating joints, regulating the permeability of blood vessel walls, regulating proteins, the diffusion and operation of water and electrolytes, and promoting wound healing. It is particularly important that hyaluronic acid has a special water retention effect and is currently the best moisturizing substance found in nature. It is called an ideal natural moisturizing factor (NMF), for example: 2% pure hyaluronic acid. Aqueous acid solution can firmly hold 98% of moisture. Hyaluronic acid is a multifunctional matrix. Hyaluronic acid (Hyaluronic acid) HA is widely distributed in various parts of the human body. The skin also contains a large amount of hyaluronic acid. Human skin maturation and aging process It also changes with the content and metabolism of hyaluronic acid, which can improve the nutritional metabolism of the skin, make the skin soft, smooth, wrinkle-free, increase elasticity, prevent aging, and also be a good transdermal absorption enhancer while moisturizing. And The combined use of other nutrients can have a more ideal effect of promoting nutrient absorption.
Hyaluronic acid name
- Another name for hyaluronic acid is hyaluronic acid. Hyaluronic acid is the wrong translation. The hyal- meaning of RESTIAID hyaluronic acid is glass-like, bright and transparent, while uronic acid refers to uronic acid. Hyaluronic acid has nothing to do with uric acid.
Hyaluronic acid structure
- Karl Meyer's laboratory clarified hyaluronic acid in the 1950s
- Structural formula of hyaluronic acid (2 photos)
- Molecular formula: (C14H21NO11) n
- The structural formula is as follows:
Main uses of hyaluronic acid
- Biochemical drugs with high clinical value are widely used in various types of ophthalmic surgery, such as lens implantation, corneal transplantation and anti-glaucoma surgery. It can also be used to treat arthritis and accelerate wound healing. Used in cosmetics, it can play a unique role in protecting the skin, can keep the skin moist and smooth, delicate and soft, full of elasticity, and has the functions of anti-wrinkle, anti-wrinkle, beauty health care and restore the physiological functions of the skin. [1]
Hyaluronic Acid
- The production process and technology of hyaluronic acid determine the difference between good and bad quality, so the products produced by the correct source must be used in order to have therapeutic effect. Generally speaking, there are three methods of extraction:
- 1. Animal tissue: The main raw materials are cockscomb and bull's eye vitreous, etc. The raw materials are degreased and dehydrated with acetone or ethanol, soaked with distilled water, filtered, and then treated with sodium chloride aqueous solution and chloroform solution, and then mixed with trypsin to obtain a mixed solution. Finally, the purified hyaluronic acid was treated and purified with an ion exchanger. This method has a very low extraction rate, only about 1%, and the separation process is complicated, making the hyaluronic acid expensive, reaching $ 5,000 per kilogram. Used in large quantities in cosmetics.
- 2, microbial fermentation: glucose as a carbon source fermentation broth. Fermentation in the culture medium for 48 hours, after the fermentation is completed, the mycelia and impurities are removed by filtration, and then simple operations such as alcohol precipitation are used to obtain high-purity products. Fermentation The advantage of hyaluronic acid produced by the method is that the molecular weight can be set according to the design of the product. The key of the fermentation method is the selection of strains, and most of them use streptococcus and lactic acid bacteria.
- 3.Chemical synthesis: using natural enzyme polymerization; firstly use polysaccharide polymer to synthesize "hyaluronic acid oxazepine derivative", then add hydrolytic enzyme to make a complex of derivative and enzyme, and finally Hyaluronic acid is synthesized by removing the enzyme from the 90 ° C reaction solution. The artificial synthesis method can greatly reduce the manufacturing cost of hyaluronic acid, but the structure is less refined.
- The same is the product of hyaluronic acid, because of the difference in raw material source and manufacturing technology, it has a significant impact on the effect. The concentration of the product cannot be used as a reference for selecting the product, and the purity, molecular weight, and 3D three-dimensional structure will directly affect the hyaluronic acid. Water absorption effect. Generally, the larger the molecular weight, the more complete the network structure, the best water absorption effect. Hygiene products and cosmetics are popular in the market, but the hyaluronic acid made by many manufacturers is cheap, but it may not be effective. Some people even promote oral administration. Hyaluronic acid, which will be broken down into small units of sugars and amino acids after absorption by the stomach and intestines, must still be produced in the skin and connective tissue through steps such as autosynthesis.The effect must also be discounted.
Differences between hyaluronic acid and other glycosaminoglycans
- HA is very different from other glycosaminoglycans. It is not sulfated, does not covalently bind to proteins, but exists in free or non-covalent complexes. Although its structure is relatively simple, its relative molecular mass is very high. Large, it is the only glycosaminoglycan that is not limited to animal tissue and is also produced in bacteria. [2]
- Features
- The main functions of hyaluronic acid are as follows:
- 1.Improve joint function
- 2.Natural moisturizing lubricant
- 3. Prevent the occurrence of arteriosclerosis, pulse disturbance and brain atrophy.
- Hyaluronic acid itself is negatively charged and is found in most soft connective tissues in animals. Its aqueous solution is a viscoelastic fluid, which fills the space between cells and collagen fibers and covers certain epidermal tissues. In animals, its main function is to protect and lubricate cells, regulate the movement of cells on this viscoelastic matrix, stabilize collagen network structure and protect it from mechanical damage. Because hyaluronic acid is a naturally lubricating and shock-absorbing polymer, it acts as a lubricant on the surfaces of tendons, tendon sheaths and mucous synovial membranes. Hyaluronic acid (hyaluronic acid) HA is widely distributed in the connective tissues of the human body, and exists almost purely in the vitreous and joint cavities of the bull's eye. The hyaluronic acid (hyaluronic acid) HA present in the skin plays an important role in the metabolism of the human epidermis. The destruction or imbalance of HA in the human body can cause diseases. Decreasing and destroying the HA content of hyaluronic acid (hyaluronic acid) in the skin can cause skin dehydration, wrinkling and loss of elasticity, making the human epidermis senescent. Therefore, hyaluronic acid (hyaluronic acid) HA is also called anti-aging factor.
- Hyaluronic acid (hyaluronic acid) HA is one of the main matrix components of human skin epidermis and dermis. Its physiological function is to allow water to enter the interstitial space of cells and combine with proteins to form protein gels, which bind cells together and play normal functions. Cell metabolism plays a role in maintaining cell moisture, protecting cells from pathogens, accelerating the recovery of skin tissue, improving wound healing and regeneration, reducing scarring, and enhancing immunity. At the same time, hyaluronic acid is the main component of the extracellular matrix of proliferating and migrating cells, especially in embryonic tissues. Because of its own characteristics, hyaluronic acid can keep cells separated from each other, make cells easy to move, migrate and proliferate, and prevent cell differentiation. During development, the role of hyaluronic acid seems to be to prevent cells from differentiating prematurely before they proliferate enough or migrate into place. In medicine, hyaluronic acid (hyaluronic acid) HA is used in non-steroidal anti-inflammatory drugs, arthritis treatment, ophthalmology, and cardiac surgery supplementary medicines, and has a unique role in the treatment of burns, burns, frostbite, artificial skin, etc.
Hyaluronic acid effect
- A large number of studies have shown that the moisture content of the human skin's surface layer (cuticle) accounts for about 15-30%. Below or above this value makes people uncomfortable, with a dry or greasy feeling. In the long-term, this can cause the skin to chapped or edema, thus Makes skin lose elasticity, rough and aging. After the hyaluronic acid (hyaluronic acid) HA acts on the internal conditioning of the skin, it can be automatically adjusted in different environments, always maintaining the skin moisture at 25-30%, keeping the skin moist and fresh, making the skin more elastic and anti-wrinkle. Wrinkle, delay the whole skin aging, beauty and beauty effect. Hyaluronic acid is one of the ingredients in the human dermis layer. It has the ability to retain moisture. The amount of hyaluronic acid is up to 100 times its own weight. Using hyaluronic acid HA-containing care products can improve dry and wrinkled skin. It restores its original smoothness and elasticity. Therefore, hyaluronic acid is the best product to improve dry and aging skin.
- Studies have shown that no matter how good a cosmetic is, it is often impossible to reach the dermis, especially because the molecular weight of HA is so high that it cannot be absorbed by the dermis. Hyaluronic acid (hyaluronic acid) HA cosmetics only act on the skin surface of the application site, increase the hyaluronic acid (hyaluronic acid) HA content on the skin surface, play a moisturizing and moisturizing role, and are local and exogenous. Hyaluronic acid (hyaluronic acid) HA can be digested and absorbed through oral administration, which can significantly increase the precursor of hyaluronic acid (hyaluronic acid) HA synthesis in the body, increase the amount of hyaluronic acid (hyaluronic acid) HA synthesis in the skin and other tissues, and make the skin Increased water retention, elasticity and reduced wrinkles. Its beauty and health-care effect is systemic. It increases the content of endogenous hyaluronic acid (hyaluronic acid) HA from the dermis to the epidermis, increases the amount of microcirculation in the blood, activates the cells, and exerts a systemic effect. It is endogenous and related to cosmetics. The use is significantly different. Therefore, endogenous hyaluronic acid (hyaluronic acid) HA must be supplemented to maintain the function of collagen, and both external and internal causes must function.
- Hyaluronic acid (hyaluronic acid) HA can also improve skin growth conditions, provide a superior external environment for the synthesis of dermal collagen and elastic fibers, strengthen the supply of nutrients, and have the effect of skin care and beauty. Studies have shown that HA can prevent the production of some enzymes in cells, reduce the formation of free radicals, and play an important role in preventing free radicals from destroying cell structure, producing lipid peroxidation and causing body aging: low molecular weight hyaluronic acid Acid has the effects of anti-inflammatory, inhibiting the production of germs and keeping the skin smooth; it provides a suitable place for cell proliferation and differentiation, and directly promotes cell growth, differentiation, reconstruction and repair.
- Hyaluronic acid is a high molecular mucopolysaccharide with DN-acetylglucosamine and D-glucuronic acid as the structural unit. Commercial hyaluronic acid is generally its sodium salt, that is, sodium hyaluronate. , Referred to as HA. It is still customarily called hyaluronic acid.
- Due to the hydrogen bonding between the monosaccharides on the linear axis of hyaluronic acid, the hyaluronic acid molecule has a rigid spiral columnar structure in space. The inner side of the column is strongly hydrophilic due to the presence of a large number of hydroxyl groups. The molecule locks its bound water molecules in its double-helical columnar structure, making it difficult to lose water, so it has a special water retention effect. The water retention capacity can theoretically reach 500ml / g, which is known as the ideal natural moisturizing factor. As age increases, HA in the body decreases. Oral health products containing hyaluronic acid can supplement HA in the body. It has the effects of delaying aging and moisturizing the skin. It has been widely used in Japan, the United States and other countries. Hyaluronic acid has been used in medicine for eye drops, surgical materials and injections.
Hyaluronic Acid Cosmetic Grade Products
- Hyaluronic acid is a natural biomolecule widely existing in the skin and other tissues. It has an excellent moisturizing effect and is known internationally as the Ideal Natural Moisturizing Factor (NMF). It is the substance with the best moisturizing properties found in cosmetics at present.
- Hyaluronic acid acts on the skin surface
- Macromolecular hyaluronic acid (molecular weight range 1 800 000 2200 000) can form a breathable film on the skin surface, make the skin smooth and moist, and can block the invasion of foreign bacteria, dust and ultraviolet rays, and protect the skin from damage;
- Medium molecular hyaluronic acid (molecular weight range 1 000 000 1 800 000) can tighten skin and moisturize for a long time;
- Small molecule hyaluronic acid (molecular weight range 400 000 1 000 000) can penetrate into the dermis, have slightly dilated capillaries, increase blood circulation, improve intermediate metabolism, promote skin nutrient absorption, have strong wrinkle-reducing function, can increase skin Elastic and delay skin aging. Measuring a good skin care product is based on the hyaluronic acid component containing three different molecular weights. The skin care product containing only a single molecular weight hyaluronic acid component has limited effects and cannot play the best skin care effect of hyaluronic acid.
- Hyaluronic acid can also promote the proliferation and differentiation of epidermal cells, scavenge oxygen free radicals, and prevent and repair skin damage. The aqueous solution of hyaluronic acid has a high viscosity, which can thicken the water phase; the paste after emulsified with the oil phase is uniform and fine, and has a stable emulsification effect. Hyaluronic acid is the best natural moisturizing ingredient for high-end cosmetics. It has good compatibility and can be added to almost any beauty cosmetic. It is widely used in creams, lotions, lotions, essences, facial cleansers, baths, and shampoos. In cosmetics such as hair expanders, mousses, lipsticks, the general addition amount is 0.05-0.5%.
Hyaluronic acid pharmaceutical grade products
- Hyaluronic acid is the main component of connective tissues such as human cell interstitial, eye vitreous, and synovial fluid. It plays an important physiological function in the body to retain water, maintain extracellular space, regulate osmotic pressure, lubricate, and promote cell repair. Hyaluronic acid
- Pharmaceutical grade hyaluronic acid
- Hyaluronic acid can be used as a visco-elastic agent for ophthalmic intraocular lens implantation, a filler for joint surgery such as osteoarthritis and rheumatoid arthritis, and is widely used as an intermediary in eye drops and also for postoperative prevention Adhesion and promote healing of skin wounds. Compounds formed by the reaction of hyaluronic acid with other drugs exert a slow-release effect on the drug, which can achieve the purpose of targeted and timed release. With the development of medical technology, the application of hyaluronic acid in medicine will become more and more extensive.
Hyaluronic acid food grade products
- The content of hyaluronic acid in the human body is about 15g, which plays an important role in human physiological activities. Decreased hyaluronic acid content in the skin, weakened the skin's water retention function, appears rough and wrinkles; reduced hyaluronic acid in other tissues and organs can cause arthritis, arteriosclerosis, pulse disturbances and brain atrophy. Decreased hyaluronic acid in the body can cause premature aging.
- Oral hyaluronic acid to increase the body's content can supplement the human body's deficiency of hyaluronic acid. Hyaluronic acid can make the skin moist, smooth, soft and elastic through digestion and absorption; it can delay aging and prevent the occurrence of arthritis, arteriosclerosis, pulse disorders and brain atrophy.
- Oral hyaluronic acid has been widely used in health foods in developed countries such as Europe and the United States. Oral hyaluronic acid (oral hyaluronic acid) is a nanotechnology product.It is a natural compound with a small molecular weight (usually refers to a biological functional molecule with a molecular weight of less than 1000 Daltons and a biologically active oligosaccharide) with an average molecular weight of only 800 Daels. The small-molecule hyaluronic acid is basically different from the "small-molecule hyaluronic acid" commonly marketed.The molecular weight of "small-molecule hyaluronic acid" in the market is generally tens of thousands, even hundreds of thousands. After oral administration into the human body, it needs the human small intestine to digest it. Decomposition can be absorbed, and the rate of absorption is small.
- Oral hyaluronic acid has a moisturizing and lubricating effect on cell tissues, making the skin plump and young and elastic, but with age and the body aging, hyaluronic acid begins to lose at the age of 18, and it starts to accelerate after 25 years of age. At the time of growth, hyaluronic acid should be replenished in a timely manner from the outside world. For 30-year-old skin, the content of hyaluronic acid is only 65% of that in infancy, and only 60% at 60 years of age. The moisture in the skin will also be lost with the passage of hyaluronic acid. It becomes dehydrated, loses luster and elasticity, and gradually appears aging such as wrinkles, rough and dull, spots. Therefore, oral hyaluronic acid or cosmetics containing hyaluronic acid has gradually become a necessary moisturizing magic weapon for beauty.
- After oral administration of hyaluronic acid is absorbed by the skin, it will form a unique three-dimensional three-dimensional structure, which provides a superior external environment for the synthesis of collagen and elastic fibers in the dermis layer. It can also absorb hundreds of times the volume of water molecules like a sponge to maintain epidermal connectiveness. Tissue intercellular lipid moisture.
Hyaluronic acid acts on the skin
- With the increase of people's age and the influence of nutrition, sunlight, environment and other factors, the human body's ability to synthesize hyaluronic acid (hyaluronic acid) HA gradually decreases, and the content of hyaluronic acid (hyaluronic acid) HA in the skin will gradually decrease. The highest HA content in the body is hyaluronic acid (hyaluronic acid), which gradually decreases after birth. If the relative content of hyaluronic acid (hyaluronic acid) HA in a 20-year-old human is located at 100%, it will drop to 65%, 45%, and 25% at the age of 30, 50, and 60, respectively. When the hyaluronic acid (hyaluronic acid) HA content in the skin is lower than a certain level, the moisture content of the surface layer of the skin will gradually decrease, causing the stratum corneum to age, and the skin will appear rough, wrinkles, loss of elasticity, and aging. It usually appears after the age of 25. This is also one of the main reasons for the skin gap between the elderly and children. At the same time, the destruction of hyaluronic acid (hyaluronic acid) HA in human skin is related to ultraviolet light, so people who have been engaged in field work, plateau life, and outdoor work for a long time appear rougher than indoor workers.
- The human double-blind clinical trial proved that the content of hyaluronic acid in blood began to increase significantly after 4 hours of oral administration, reached a peak in 12 hours, and was 70 times higher than that of the control group. Stable concentration can be achieved after 7 days of continuous service.
Hyaluronic acid skin care
- Hyaluronic acid, as an ingredient in the pharmaceutical field, has been fully demonstrated in the cosmetics industry. Here is a brief introduction:
- Corresponding beauty appeal: Hyaluronic acid, which is already present in skin tissue, has super moisturizing power. It is called "Key to the fountain of youth" on foreign websites.
Hyaluronic acid absorbs moisture
- Hyaluronic acid can help the skin to absorb a large amount of moisture. With moisture, the skin can naturally remain elastic and soft. Not long ago, we could only add hyaluronic acid to the skin through medical injection. Medical skin care products can use a small amount of hyaluronic acid as a humectant, and compress and pack millions of molecular weight hyaluronic acid to the skin. Absorbs about 1,000 times its own weight of water, refills epidermal cells and smoothes wrinkles. Although the effective time is not as long as the direct injection, it can be continuously replenished daily to let the cells fill up naturally.
Hyaluronic acid repair and water retention
- The English name HYALURONIC ACID is a transparent gel that instantly moisturizes and deepens the skin's elasticity and tension. It helps to restore the normal oil-water balance of the skin and improve dry and relaxed skin. Hyaluronic acid is also an important ingredient in the skin and has the function of repairing the epidermal tissue. When the skin tissue is exposed to UVB rays, the skin will be sunburned and inflamed, and the dermal tissue will stop producing hyaluronic acid and accelerate the decay rate of hyaluronic acid. Hyaluronic acid is abundantly present in the connective tissue and dermis of the human body. It has strong water absorption and moisturizing functions, can also enhance the skin's ability to retain water for a long time, and can help elastic fibers and collagen to stay in a water-filled environment. Skin appears more elastic.
- Different molecular weights of hyaluronic acid have different abilities to penetrate into the skin, and the effects brought by them are also different. The following table describes the different effects of different molecular weights of hyaluronic acid (large molecular weight, medium molecular weight, small molecular weight).
- Efficacy of Sodium Hyaluronate Molecular Weight Range
- Large molecular weight 1 800 000 2 200 000 Prevents dehydration, regenerates tissue cells and tightens skin
- Medium molecular weight 1 000 000 1 800 000 Tighten skin, moisturize for a long time
- Small molecular weight 400 000 1 000 000 Rapid hydration with cells
- Hyaluronic acid gradually forms a moisture-rich film in the stratum corneum, and at the same time transports water inward and outward. Therefore, when the environment is dry, it is also necessary to rely on the sealant to reduce its outward moisture evaporation in order to maintain moisture lasting. Blocking agents can form a thin film on the surface of the skin to prevent water from "running". They are usually oily, such as petroleum jelly, mineral oil, and silicone derivatives.
- Emollients fill the gaps between the outermost cells of the epidermis, making the surface texture of the skin smooth and soft, reflecting the efficacy of cosmetics and beauty effects in a short time. According to different internal characteristics, it can be divided into protective, degreasing, dry or astringent. In addition to moisturizing, hyaluronic acid also has the function of a little emollient; there are condom lubricants that can be added with hyaluronic acid, an oily lubricant of silicone oil, and a water-soluble lubricant. Hyaluronic acid has a low molecular weight and is water-soluble. According to similar compatibility principles, it can only be added to water-soluble lubricants. There are not many condom products on the market that meet this condition, only Okamoto 003 hyaluronic acid products and Akao's full range of products.
- In fact, the well-known moisturizing products on the market are often a "mixture" of the three, and specific formulas are often used for specific skin types to adjust the water-oil ratio. Therefore, when buying skin care products, you need to know your skin texture first, and then find the formula and dosage form that suits you!
Cosmetic effects of hyaluronic acid
Remove wrinkles with hyaluronic acid
- Due to age, smoking, squeezing during sleep, and traction by gravity, the hyaluronic acid will be lost from the skin, which will gradually reduce the collagen and elastic fibers of the dermis, cause skin relaxation, and cause facial wrinkles. Acid can effectively resolve a variety of wrinkles:
- 1. Hyaluronic acid is applied to frown lines (brown lines) and crow's feet
- Excessive depressed frown lines, when injected with botulinum toxin alone, often do not give satisfactory results, and when injected with hyaluronic acid, the effect will be better.
- 2. Hyaluronic acid beauty is applied to mouth corner lines
- The lines that occur when you muzzle are dynamic lines, which are recessed with hyaluronic acid
- Hyaluronic Acid Wrinkle Removal
- 3. Applying hyaluronic acid beauty to law lines (nasal labial groove)
- Elimination of decree lines is the most commonly used purpose in the wrinkle removal effect of hyaluronic acid. According to the depth of the wrinkled nose and the depth and location of the wrinkles, it usually takes about 2 injections of macromolecules. The injection site includes the depression of the lateral nasal wing, the law pattern itself and the underside of the lips.
- 4.Hyaluronic acid applied to wrinkles around the mouth
- Including fine lines around the mouth, that is, dry lines around the lips due to chronic lack of water; including corner lines, where the corners of the mouth pass when drooling, some form small parentheses, and some form large parentheses (with the nose Cleft lip grooves together).
Hyaluronic acid shaping
- Rhinoplasty: Although the development of rhinoplasty technology has reached a certain height, then since hyaluronic acid injection is used for rhinoplasty, rhinoplasty because of the rapid formation of rhinoplasty, no need for surgery, no pain and other advantages make prosthesis rhinoplasty, etc. Rhinoplasty has been challenged.
- Takashi Takashi: Today's popular V-shaped face can be easily realized from the chin. Can also solve the problem of chin shrinkage.
Filling the face with hyaluronic acid
- The aging of people will cause changes in the distribution of subcutaneous tissues, depressions around the temporal area, cheeks, eye sockets, eyebrow arches, lips, and tear grooves. Hyaluronic acid is used for facial fillings including tear grooves, law lines, and puppet lines ( Women's three (eight) lines) were all welcomed and the effect was better.
- Lip enhancement: Generally speaking, a person's lips will shrink with age, wrinkles will appear, and the corners of the mouth will sag due to aging. Hyaluronic acid filled lip enhancement has received certain praise.
Hyaluronic acid filled dents
- Hyaluronic acid can also be used to fill some acne scars, trauma, scars caused by surgery, and the asymmetry of congenital defects.
Hyaluronic acid skin care
- Hyaluronic acid originally exists in the skin, which can help the skin to absorb water from the body and the surface layer of the skin, and also enhance the skin's ability to retain water for a long time. After the hyaluronic acid absorbs water, the elastic fibers and collagen are full of moisture In this environment, the skin is elastic. However, the skin's hyaluronic acid has been lost since the age of 25. At the age of 30, only 65% of juveniles are left, and at the age of 60, only 25% is left. With the loss of hyaluronic acid, it loses its elasticity and gloss, and wrinkles will age over time.
- Moisturizing and blocking is the dual mission of skin care. Real high-quality hyaluronic acid must be an organic combination of large molecules and small molecules. Hyaluronic acid (tens of thousands to hundreds of thousands of Daltons) cannot penetrate the skin. However, it can form a breathable film on the surface of the skin, make the skin smooth and moist, and block the invasion of foreign bacteria, dust, and ultraviolet rays, and protect the skin from damage; small molecules of hyaluronic acid (nanohyaluronic acid as low as 1000 molecular weight) Acid HA800, small molecules of OCO can easily penetrate the skin) It has the functions of anti-inflammatory, inhibiting the production of germs and keeping the skin smooth; it can penetrate into the skin and synthesize the skin's endogenous macromolecule hyaluronic acid to achieve water retention; for cell proliferation and differentiation Provide a suitable place to directly promote cell growth, differentiation, reconstruction and repair.
Hyaluronic acid side effects
- Occasionally urticaria, dermatitis, pruritus should be discontinued and treated appropriately.
- Sometimes pain, swelling, obstruction of water flow, and occasionally edema, redness, heat, and local pressure.
- As we all know, it is because a substance called "hyaluronic acid" is excessively distributed on the whole skin of Shar Pei dogs that causes it to produce so many wrinkles. The excess of hyaluronic acid is probably caused by over-activation of a gene called "hyaluronic acid synthase 2".
- When the synthetase gene is over-activated, the human body will produce corresponding enzymes to break down and destroy excess parts, playing a certain "self-regulating" role. Hyaluronidase can dissolve excess hyaluronic acid, thereby eliminating side effects.
Notes on Hyaluronic Acid
- Hyaluronic acid should be handled aseptically and limited to one use. It is prohibited to use hyaluronic acid after it is damaged.
- It is not advisable to inject when arthritis is obvious, and then inject the hyaluronic acid gel after the inflammation is eliminated.
- In the case of joint effusion, puncture and drainage of hyaluronic acid gel outside the joint cavity may cause pain, so it must be injected into the joint cavity.
- Sometimes it causes pain. After injection of hyaluronic acid gel, it is treated quietly locally.
- When hyaluronic acid encounters bactericidal and disinfectant benzalamine, quaternary salt, etc., it will cause precipitation, and you should pay full attention when using it.
- Pregnant women and lactating women should be used with caution, those with impaired liver function, and those with allergy to hyaluronic acid gel.
Hyaluronic acid suitable age
- Hyaluronic acid is suitable for any age group in need of treatment. Injecting hyaluronic acid at any age will not cause side effects, mainly depending on whether your skin condition requires injection of hyaluronic acid.
Precautions for Hyaluronic Acid Injection
- 1.Precautions before injection:
- Before treatment, please keep the skin clean. Any cosmetics and skin care products need to be cleaned. It is recommended to use cleansing milk and astringent water to clean the skin. Use cold water to clean the pores. It is strongly recommended that patients have at least 3-4 days before treatment Do not take anti-inflammatory drugs (such as aspirin, etc.), because it may exacerbate bleeding and swelling at the injection site.
- 2.Notes after injection:
- After the injection treatment, please keep your face relaxed and do not make too many facial expressions. For at least two weeks after the treatment, please avoid contact with high heat environment (such as sauna, etc.), because it may cause the injection of hyaluronic acid on the face to be very harmful. Decomposes quickly, which shortens the filling effect. Do not touch or massage the injection site.
- 3.Adverse reactions:
- The skin has an inflammatory reaction, usually accompanied by pressure pain, which lasts for about a week, and the injection site temporarily swells. If the adverse reaction persists, please notify the injection doctor immediately.
- 4.Contraindications:
- Women who are pregnant or breastfeeding, patients under 18 years of age, locally inflamed or infected skin, and injected with this product while taking anticoagulants are at great risk of swelling or bleeding, such as taking aspirin and nonsteroidal anti-inflammatory drugs. Doctors are advised to ask the seeker before injections if they are allergic to hyaluronic acid and have a previous medical history.
- be careful
- 1. Be well prepared. You can choose a trusted medical unit or doctor to perform surgery to eliminate your fear of hyaluronic acid injection. You must be full of determination and security, and you must calmly cooperate with doctors to achieve good hopes. Do not blindly inject hyaluronic acid to avoid adverse results.
- 2. Before hyaluronic acid injection, you must fully understand the related knowledge and reflect on related books. It is best to visit people who have already injected hyaluronic acid. It is best to see the whole process of hyaluronic acid injection.
- 3. Before the injection of hyaluronic acid, the injection site must not contain any bacterial lesions: such as folliculitis, edema, acne, acute ophthalmia, sinusitis, rhinitis, nasal vestibule, etc.
- 4. It is best to take a bath the day before hyaluronic acid injection. Before going to the operating table on the day of hyaluronic acid injection, wash the dirt and oil on the face with soap to minimize the number of bacteria. Before the injection of hyaluronic acid, there were other diseases in the body, which caused a low resistance. It also randomly caused infections of hyaluronic acid injection and affected wound healing.
- 5, women can not do hyaluronic acid injection during menstruation, so as to prevent postoperative infection.
Distinguish between genuine and fake products of hyaluronic acid
- There are generally five types of micro-plastic injection fillers on the market that are easily confused with hyaluronic acid, including: olmeadine (or Ingelfolk), silicone oil, paraffin oil, cellulose, and collagen. There is one A simple method to identify omemetine-some of the "hyaluronic acid" that contains omemetine are mostly sold in beauty salons and some unqualified plastic surgeons bring them to beauty salons to inject them into beauty salons. The injection in the hospital, the temporal part shows the edema state after the injection, which is the performance of omemetine. All the streets are filled with fake hyaluronic acid and collagen. The illegal elements have won some low consumption power with low prices. Appealers are favored, and they are deceived, so they need good identification.
- Identification steps:
- The first step: squeeze a drop of gelatinous substance from the needle tube and place it on white paper. If there is oil infiltration and diffusion, then this thing is definitely not hyaluronic acid, it must be silicone oil or paraffin oil. This material, it is something that is explicitly prohibited by law.
- Step 2: If it is forming a water-infiltrated halo diffusion, it may be hyaluronic acid, olmeadine (or Injfale), cellulose or collagen. At this time, further identification is required! The identification method is: take a drop Hyaluronic acid is placed on the palm of the left hand, and then repeatedly touched with the fingertips of the right hand. After a few minutes, after most of the water has evaporated, through finger touch or visual observation, sandy crystal particles are found in the remaining residue. There is nothing else besides that, this is cross-linked hyaluronic acid, which can basically be confirmed to be real hyaluronic acid and can be used.
- The third identification method: put the extruded product on a flat glass plate, and observe it the next day. As a result, after one night of water volatilization, the residual type components on the glass plate are analyzed. Type ingredients, like "ice smooth" particles, it must be hyaluronic acid. If it is "crust-like opaque crust, it is generally omeridine; 'If it is a soft pale yellow soft film, Generally it is cellulose. If it is non-volatile oil, it must be silicone oil or paraffin oil. If nothing is left in the end, it is likely to be non-crosslinked hyaluronic acid!
- The fourth identification method: To identify whether the solid component is hyaluronic acid, you can use an enzymatic hydrolysis experiment. The procedure is: in a 45-degree temperature water bath, place the solid particles in a container containing hyaluronidase. Generally, about 2 hours, the solid particles can be degraded. If it is not degraded, it is definitely not hyaluronic acid. (This is the brine point tofu, one thing drops one thing! The corresponding enzyme, dissolves the corresponding compound)
- Through the above methods, no one can fool you! Identifying the cross-linked hyaluronic acid is true or false, you are a master!
Hyaluronic acid synthesis method
- 1. Add chicken crown pieces to acetone and soak overnight until the chicken crown is dehydrated and hardened. It is then placed in a porcelain dish for drying. After drying, it is pulverized into powder by a pulverizer. Pour the cockscomb powder into an enamel jar, add 6-7 times distilled water, stir well, soak it for more than 24 hours to fully swell the cockscomb powder, then filter, collect the filtrate, soak the filter residue 3 times in the same way, and combine 3 times the filtrate The filtrate was then poured into a ceramic jar, 10% solid sodium chloride was added with stirring, and an equal volume of chloroform was added. After stirring for 3 hours, the aqueous phase was separated. Add 2 volumes of 95% ethanol to the separated aqueous phase, stir well, and let stand overnight to precipitate hyaluronic acid, then filter dry the precipitate and dry to obtain a crude product. The crude product was redissolved in 4 times the volume of a 0.1 mol / L sodium chloride solution, adjusted to a pH of 4.5 to 5 with dilute hydrochloric acid, and an equal volume of chloroform was added. After standing, the layers were separated and the upper aqueous phase was aspirated. The aqueous phase was adjusted to pH = 7.5 with 8% sodium hydroxide solution, streptase protease was added, and incubated at 37 ° C for 24 hours. It was then extracted twice with an equal volume of chloroform, and the upper aqueous phase was combined, and the lower liquid was recovered as chloroform. An equal volume of a 1% cetylpyridine chloride solution was added to the aqueous phase, stirred well, the precipitate was left to stand, filtered, and the precipitate was collected. The precipitate was dissolved with 2 to 3 times the volume of 0.4 mol / L sodium chloride, filtered, and 3 times the volume of 95% ethanol was added to the filtrate. The precipitate was left to stand, the upper ethanol was removed by suction, and the lower layer was repeatedly precipitated twice with 95% ethanol. The lower layer of the precipitate is suspended and filtered, dried, washed with acetone twice, and dried under vacuum to obtain a finished product.
- 2. Fermentation of microorganisms (mutant strain Y921 strain of HA-producing Streptococcus zooepidemicus).
Hyaluronic acid storage method
- Plastic bags lined with kraft paper in closed light sealed packaging or in brown glass bottles. Protect from moisture and sun.