What Are the Different Types of Hormone Therapy Drugs?

Broad definition: Hormone drugs are drugs that use human or animal hormones (including organic substances with the same structure and principle of hormones) as active ingredients. Narrow definition: In general, the "hormonal drugs" in the doctor's mouth is usually the abbreviation of "adrenal glucocorticoid drugs" unless otherwise specified. For other hormonal drugs, their classification names are commonly used, such as "androgen", "insulin", "growth hormone" and so on.

Hormones (such as prednisone,

Indications for glucocorticoids

infection,

As a kind of drug with rapid and obvious effects but serious side effects, hormonal drugs have always been controversial. Generally, hospitals should avoid using this drug as much as possible.

World-renowned pharmaceutical company Merck recently announced the results of a new clinical study: long-term use of hormone drugs may slow children's growth and development. The study used a multicenter, double-blind, randomized, parallel-group trial of treatment and placebo to observe 360 patients with mild childhood asthma over 56 weeks. The clinical study was divided into three groups: beclomethasone (hormonal drugs) group, montelukast sodium (non-hormonal drugs) group, and placebo group. 56

Long-term super physiological doses may appear

Introduction to various adrenal hormones

1.dexamethasone

Alias: Desamesol;

Dermatological abuse of hormone therapy with severe consequences

Corticosteroids (commonly known as hormones) have anti-allergic, antipruritic, and anti-inflammatory effects. However, the side effects and adverse effects caused by the abuse of these drugs have also become the focus of medical experts. Should pay great attention to medical workers and patients.

Corticosteroids are used externally, orally or by injection in the clinical treatment of skin diseases.

Topical dermatitis, fluocinolone (easy skin), le skin fluid and other ointments or creams are synthetic hormone preparations for a variety of skin diseases such as contact dermatitis, eczema, prurigo, neurodermatitis and seborrheic dermatitis Effective. Especially for the itching caused by these skin diseases, it has a certain antipruritic effect.

However, each drug has a side effect on the patient and a side effect (ie, side effects). Some people use hormones as a panacea for treating skin diseases. Without the diagnosis of a dermatologist, they have a little discomfort (especially on the face). As a result, there are complications that cause people to worry about.

For some infectious skin diseases, external use of these drugs is not only ineffective, but also reduces local resistance, worsens the condition, and even causes drug-dependent dermatitis (hormonal-dependent dermatitis).

If you use topical hormone preparations for a long time, you will still be addicted, and its side effects are about 20 kinds. The most common one is that the condition improves rapidly after application, and continues to be used for a period of time. Once the drug is stopped, redness, tenderness, itching, cracks, and desquamation may occur in the area (especially the face) within one or two days. The worsening of the primary lesion is called rebound dermatitis. When hormones were reapplied, the above conditions quickly improved or disappeared; if the drug was stopped, rebound dermatitis recurred, and it was more severe than before. In order to avoid pain after drug withdrawal, patients rely entirely on the application of hormones. After a few months or years, the skin becomes noticeably thinner, the capillaries are dilated, and purpura sometimes appears. Especially deeper persistent erythema can appear on the face. The longer the application time, the more severe the rebound dermatitis is. Can make the skin thin, fragile, atrophic, capillary dilatation, purpura, fungal infections, acne-like dermatitis and so on. Becomes more susceptible to damage; milder hairiness, sweating, subcutaneous bleeding, and difficulty healing wounds can also occur.

The following skin diseases are not suitable for the above-mentioned hormones for external use:

1. Skin diseases such as tinea pedis (also known as Hong Kong feet) and tinea corporis are caused by epidermal ringworm, and hormone drugs do not directly kill or inhibit these ringworm bacteria. Therefore, tinea pedis, tinea corporis is easy to use, skin lotion and dermatitis usually can only temporarily control the inflammation and antipruritic effect, but it is impossible to kill ringworm, such as prolonged or repeated use, it will aggravate and spread ringworm. .

2, impetigo, scabies and purulent skin diseases, hormone drugs are not suitable. Because these skin diseases are also caused by bacteria, rubbing these drugs will not only cure these diseases, but also exacerbate the condition and increase pain.

3, herpes simplex and shingles, herpes simplex growing on the lips and shingles growing on the body, it is more inappropriate to use such drugs. Because these skin diseases are caused by viruses smaller than bacteria, and hormonal drugs do not kill and inhibit the virus, if the topical hormones are used for herpes, the infection of the affected area will be exacerbated.

4. Young people's acne (acne) is a common skin disease caused by strong sebaceous glands in adolescence. This skin disease is prone to infection and pustules or inflammatory nodules. If you apply hormonal drugs at this time, it is even more harmful and useless. In particular, do not use it on the face for a long time, otherwise it will cause skin atrophy, thinning, telangiectasia, pigmentation, and skin wrinkling and aging. Especially infants and young children have delicate skin, which is not suitable for long-term large-scale use, because it is a strong hormone preparation. After skin absorption, it can cause adrenal cortex function inhibition and bring serious adverse consequences.

5. Seborrheic dermatitis: The cause of seborrheic dermatitis is believed to be related to gonad secretion disorders, which are caused by hyperandrogen secretion. It is also related to digestive dysfunction, excessive sugar and fat, mental stress, overwork, bacterial infection, and vitamin B deficiency.

In our outpatient treatment, it is often found that some patients with seborrheic dermatitis cause serious side effects and adverse consequences due to the abuse of hormone drugs. Among them, several patients with seborrheic dermatitis have applied various corticosteroids such as Pikangwang cream, dermatitis flat cream, skin relaxing cream, freckle cream, beclomethasone cream, etc. in rotation for many years. Causes drug-induced Cushing's syndrome. It can be seen that even if the corticosteroids are rubbed externally in a small area, if the time is too long, it can also cause systemic side effects.

Other adverse reactions:

For long-term or short-term high-dose injections or oral dexamethasone, Corning pass, prednisone, cortisone, clobetasol and other corticosteroid drugs, or the application of so-called secret preparations containing hormones whose truth is unknown, The consequences are even more unimaginable; not only can it cause obesity, hairiness, acne, elevated blood sugar, high blood pressure, sodium retention, edema, decreased blood potassium, menstrual disorders, osteoporosis, sterile osteonecrosis, stomach and duodenum Ulcers and other conditions. It can also cause some damage to the kidney itself, such as aggravating glomerular disease proteinuria, aggravating glomerular sclerosis, prone to renal calcification or kidney stones, inducing or aggravating renal infectious diseases, causing hypokalemia and polycystic kidney disease Wait. Giving a larger dose of glucocorticoid for a longer period of time can also cause a series of metabolic disorders and temperature regulation disorders of the body's sugar, protein, fat, and water and electrolytes, which will damage the body's defense system and suppress the immune response ability, and severely inhibit the hypothalamus. -Pituitary-Adrenal axis, which can cause a series of more serious side effects and complications, some of which can directly threaten the patient's life. For example, after the above drugs are abused by patients with psoriasis, once the drug is discontinued, the primary disease will not only worsen, and the above side effects and adverse consequences will occur. It may also induce more severe erythrodermic and pustular psoriasis.

Therefore, the use of corticosteroids should be carried out carefully, and do not use large doses for a long time or a short time, so as not to cause the above adverse consequences. If the condition is urgently needed, it must be reasonably applied under the correct guidance of a specialist. If some patients use corticosteroids in the course of treatment and rely on hormones, the rebound of the primary lesions and the secondary side effects will increase after the drug is discontinued. Family members of patients should do their ideological work well, have a full understanding of the effects and side effects of hormones, and enhance their confidence in defeating the disease. And in the case of correct choice of treatment drugs and gradually reducing until the withdrawal of corticosteroids, methods and Chinese medicines to combat the above side effects and adverse reactions are selected. To achieve the goal of safe and complete cure.

Dexamethasone, prednisone and other drugs are glucocorticoid drugs, which are widely used in clinical practice and have anti-inflammatory, anti-immunity, anti-toxin, anti-shock effects. In severe infections such as sepsis, toxic pneumonia, encephalitis and other high fever crisis, application can improve the body's tolerance to bacterial endotoxin, reduce the harm of bacterial toxin to the body, and quickly reduce the high fever.

Improper use of glucocorticoids can complicate and exacerbate infections. Long-term use can reduce the body's defense ability, which can easily lead to the occurrence of staphylococcal infections or viral diseases. Hormones can accelerate protein catabolism and inhibit protein synthesis; hormones can also inhibit the development and differentiation of lymphocytes, reduce the immune defense response, and affect children's immunity; can delay wound healing; stimulate and aggravate peptic ulcers; sudden decline in high fever also May cause collapse or fainting. Therefore, these hormones cannot be used as conventional antipyretics.