What Are the Uses of Collagenase Ointment?

Collagenase ointment is suitable for enzymatic debridement of burn wounds and promote wound healing.

Collagenase ointment is suitable for enzymatic debridement of burn wounds and promote wound healing.

Drug Name

Collagenase ointment

Drug type

prescription

Use classification

Surgical and antiseptic

Collagenase ointment ingredients

Collagenase

Collagenase ointment properties

This product is off-white or yellowish ointment.

Collagenase ointment indications

Enzymatic debridement for burn wounds and promotion of wound healing.

Collagenase ointment specifications

15g: 3750 units.

Collagenase ointment dosage

Daily or every other day. Use as follows:
1. Before treatment, gently wash the affected area with physiological saline.
2. When an infection occurs, the affected area can use appropriate antibiotics, and then apply this product: If the infection continues, suspend application of this product, and continue to apply this product after the infection has resolved.
3 This product can be applied directly on the affected area, or on gauze and applied on the affected area.

Collagenase ointment adverse reactions

This product is well tolerated. Possible adverse reactions are local pain, burning or tingling.

Collagenase ointment contraindications

Those with local and general allergies to the ingredients contained in this product are prohibited.

Notes on collagenase ointment

The optimal pH range of collagenase is 6-8. Too high or too low pH will reduce the activity of this product, so proper attention should be drawn.
Enzyme activity is also affected by detergents and heavy metal ions. For example, enzyme activity is inhibited by mercury and silver used in some preservatives. When you suspect that you have been in contact with these things, you should carefully rinse the affected area repeatedly with normal saline before using this product.
Also avoid soaking with metal ions and acidic solutions, because such solutions have metal ions and the pH will be low.
Detergents such as hydrogen peroxide solution, sodium hypochlorite solution, and physiological saline are compatible with this product.
Because in theory enzymatic debridement may increase the risk of bacterial infection, close attention should be paid to systemic bacterial infections in critically ill patients.
When this product is applied to surrounding tissues outside the wound, occasional slight temporary erythema appears, so the ointment should be carefully applied to the wound.

Collagenase ointment for pregnant and lactating women

still uncertain.

Collagenase ointment for children

still uncertain.

Collagenase ointment for the elderly

still uncertain.

Collagenase ointment drug interaction

Silver and mercury in detergents and preservatives can reduce the activity of this product.

Collagenase ointment overdose

It has been confirmed in clinical investigation and clinical application that there is no systemic or local reaction of overdose. Sometimes, if deemed necessary, the affected area can be scrubbed with polyvinylpyrrolidone iodine to deactivate collagenase.

Collagenase ointment pharmacology and toxicology

This product is an enzyme medicine. Because collagen accounts for 75% of skin weight, collagenase has the function of hydrolyzing natural collagen at physiological pH and temperature, and it has the unique function of digesting natural and denatured collagen in necrotic tissue.
If the necrotic tissue fixed by the collagen at the base of the wound is removed, the healing of the wound will be accelerated. Collagenase is the only collagenase capable of breaking down its own collagen. Collagenase breaks down the necrotic tissue of the wound and promotes the formation of granulation and epithelial tissues on the wound. Normal epithelium, granulation tissue, adipose tissue, and healthy tissues around the wound will not be damaged. In bacterial infectious wounds, the necrotic tissue is degraded by enzymes to cause bacteria to lose the growth medium, thereby reducing wound infection.

In the process of wound healing, the amount and activity of endogenous collagenase are affected, so it is necessary to supplement the exogenous collagenase. The decomposition of collagenase not only makes the necrotic tissue loose and easy to remove, so that the wound can grow and repair normally. At the same time, the peptide chain molecules generated after collagen degradation can further chemo into fibroblasts, inflammatory cells, etc., and accelerate keratinocyte Proliferation and movement thereby accelerate wound healing.

Pharmacokinetics of collagenase ointment

still uncertain.

Collagenase ointment storage

Shaded, sealed, and stored in a cold place (2-10 ° C).

Collagenase ointment packaging

Quality medicinal ointment tube; 15g / piece / box.

Collagenase ointment expiration date

24 months.

Collagenase ointment implementation standard

YBH09992009 ^[1]