What Are the Different Types of NSAID Medications?

NSAID (Nonsteroidal Antiinflammatory Drugs, NSAIDs) is a class of anti-inflammatory drugs that do not contain a steroid structure ^[1] , which is used for antipyretic, analgesic, and anti-inflammatory. At present, there are more than 100 kinds of brands on the market.

NSAID

NSAID (Nonsteroidal Antiinflammatory Drugs, NSAIDs) is a class of anti-inflammatory drugs that do not contain a steroid structure ^[1]

NSAIDs have different chemical structures, but they all exert their antipyretic, analgesic, and anti-inflammatory effects by inhibiting the synthesis of prostaglandins.

1, gastrointestinal adverse reactions: upper abdominal discomfort, pain, nausea, vomiting, fullness, belching, loss of appetite and other symptoms of indigestion. About 10% to 25% of patients with long-term oral non-steroidal anti-inflammatory drugs

The 9 risk factors that are prone to cause gastrointestinal adverse events are: (1) advanced age (age 60 years); (2) history of gastrointestinal ulcers; (3) use of anticoagulants; (4) use of NSAIDs; (5) Use of glucocorticoids; (6) use of low-dose aspirin; (7) Helicobacter pylori infection; (8) smoking; (9) alcoholism. Excluding any of the above risk factors is a low risk of gastrointestinal tract; including one or two risk factors is a moderate risk of gastrointestinal tract; including three or more risk factors is a high risk of gastrointestinal tract.

According to the results of the Logica study published in the 2010 Journal of Rheumatology (ARD): More than 86% of patients with osteoarthritis who require nonsteroidal anti-inflammatory analgesics have one or more gastrointestinal Risk factors, of which, 22.3% of patients were high-risk groups, 64.3% of patients were middle-risk groups; only 13.4% of patients were low-gastrointestinal risk groups. For those with gastrointestinal risk factors, the risk of gastrointestinal tract taking traditional non-steroidal anti-inflammatory analgesics can be as high as 13.5 times that of the normal population.

For high-risk patients in the gastrointestinal tract, it is necessary to develop good living habits and ensure gastrointestinal health, such as quitting smoking and alcohol, developing good eating habits, and adjusting mentality to relieve stress. For those who already have gastrointestinal symptoms, they should seek medical treatment early, make a clear diagnosis, and cooperate with treatment. Take prophylactic drugs when taking NSAIDs, or choose NSAIDs with high gastrointestinal safety, such as selective COX-2 inhibitors.