What Are the Different Types of Scalp Ointment?

Calcipotriol ointment for topical treatment of psoriasis vulgaris.

Drug Name: Calcipotriol ointment
Drug type: Occupational injury medical insurance

Hanyu Pinyin: Ka Bo San Chun Ruan Gao
Use classification: Antikeratosis

Carbotriol ointment ingredients

The main ingredient of this product is calcipotriol.
Chemical name: 9,10-ring-opening cholesterol-24-cyclopropyl-5,7,10 (19), 22-tetraene-1,3,24triol.
Chemical Structure:

Molecular formula: C ₂₇ H ₄₀ O ₃
Molecular weight: 412.61

Calcipotriol Ointment Properties

This product is a white ointment without preservatives.

Indications for calcipotriol ointment

For local treatment of psoriasis vulgaris.

Carbotriol Ointment Specifications

0.005% (15g: 0.75mg, 30g: 1.50mg)

Carbotriol Ointment Usage and Dosage

Apply this product a small amount to the affected skin 1 to 2 times a day. It is recommended to administer twice a day at the beginning of treatment, and can be reduced to once a day when appropriate. The maximum dosage per week should not exceed 100g.

Adverse reactions of calcipotriol ointment

Very common> 1/10
Common> 1/100 and <1/10
Rare> 1/1000 and <1/100
Rare> 1/10000 and <1/1000
Very rare <1/10000
The most commonly reported adverse reactions are mostly skin reactions. Especially the reaction at the site of application. Reports of hypercalcemia and allergic reactions are rare.
According to clinical data, the incidence of adverse reactions of Darius® ointment is about 15%.
Pruritus, skin irritation, burning, stinging, dry skin, erythema, and rash are more common. Deterioration of contact dermatitis, eczema, and psoriasis is rare.
Hypercalcemia and hypercalciuria, which cause systemic reactions after topical use, are very rare.
Post-marketing data for Darius® creams, ointments, and scalp tinctures are rare. There have been reports of transient skin pigmentation, transient photosensitivity, and allergic reactions including urticaria, angioedema, periocular edema, or facial edema. Perioral dermatitis is rare.
According to post-marketing data, the overall rate of reported adverse reactions is very low. Approximately 1: 10,000 patients.
The McdDRA SOC lists adverse reactions, with individual adverse reactions listed in order of frequency of occurrence.
Skin and subcutaneous discomfort itching, burning, skin tingling, skin irritation, dry skin, erythema, rash *, eczema, contact dermatitis, exacerbation of psoriasis, skin pigmentation, hypopigmentation, photosensitivity, urticaria , Facial edema, eye edema, angioedema.
* Different types of rashes have been reported, such as squamous, erythema, maculopapular, and pustular.
Metabolic and nutritional disorders:
Hypercalcemia, hypercalciuria.

Carbotriol Ointment Contraindications

1. Those who are allergic to any component of this product are prohibited;
2. Calcium metabolism disorders are disabled.

Precautions for Carbotriol Ointment

Darius® ointment should not be applied to the face. Patients must use this product correctly according to the instructions to avoid direct application on the face and accidental application on the face. Care must be taken to wash away any medication left on the hands after each application.
Patients with severe renal failure or severe liver dysfunction should avoid using Dulux®.
The risk of hypercalcemia when using this product at the recommended dosage is very small. If the weekly usage exceeds the maximum dosage (100g), it may cause hypercalcemia, and the serum calcium level can return to normal soon after discontinuation.
During the treatment with Darius®, a doctor is recommended to advise patients to limit or avoid excessive exposure to natural or artificial light. Topical calcipotriol can be used in combination with UV radiation only when both the doctor and the patient believe that the potential benefits outweigh the potential risks.
This product contains propylene glycol, which may cause skin irritation.

Carbotriol ointment for pregnant and lactating women

Animal experiments have not found this product to have teratogenic effects, but the safety of this product for pregnant women has not been determined. It is uncertain whether calcipotriol is excreted through milk, so this product should not be used during pregnancy and lactation.

Carbotriol ointment for children

The safety of this product for children has not been determined.

Carbotriol ointment for the elderly

The test was not performed and there are no reliable references.

Carbotriol Ointment Drug Interactions

The test was not performed and there are no reliable references.

Carbotriol Ointment Overdose

Excessive use of this product (more than 100g per week) may cause hypercalcemia, and serum calcium levels can quickly return to normal after withdrawal. It has been reported that hypercalcemia occurs in patients with generalized pustular psoriasis or erythrodermic psoriasis at lower doses.

Calcitriol Ointment Pharmacology and Toxicology

Pharmacological effects:
This product is a topical preparation of vitamin D derivative calcipotriol, which can inhibit the proliferation of skin cells (keratinocytes) and induce their differentiation, thereby correcting the abnormal proliferation and differentiation of psoriatic skin lesions.
Toxicology research:
The effect of this product on calcium metabolism is about 1/100 of the hormone-activated vitamin D3.
Skin cancer studies in mice have shown no particular risk of skin cancer. The calcipotriol solution is 3, 10, and 30 mg / kg / day (in terms of body surface area, 9, 30, and 90 mg / m ² / day, respectively. It is equivalent to the maximum recommended daily dose of 60 kg for adults 0.25, 0.84 and 2.5 times) topical use for 24 months. High doses are the skin's maximum tolerated dose of calcipotriol. Survival rates were reduced in the 10 and 30 mg / kg / day groups, especially for male rats. Reduced survival is associated with increased incidence of obstructive urinary tract disease. The biggest change related to treatment may be a change in urine composition. This is in line with expectations for the use of high-dose calcipotriol and vitamin D analogs. No effects on the skin, no transdermal or systemic carcinogenesis.
In a study of albino nude mice, repeated exposure to UV radiation and topical use of calcipotriol for 40 weeks, the drug dose level was the same as the previous transdermal carcinogenicity test, and a reduction in skin cancer with reduced UV radiation was observed (Statistically significant in male mice), suggesting that calcipotriol may increase the effect of UV-induced skin cancer. The clinical relevance of these findings is unknown.

Pharmacokinetics of calcipotriol ointment

Kinetic studies show that oral administration is metabolized by the liver and has a short half-life. Human liver homogenate experiments show that human metabolic pathways are similar to those of rats, guinea pigs, and rabbits, and the main metabolites have no pharmacological activity.
Calcipotriol is absorbed through the skin at 1-5% of the administered dose.

Carbotriol Ointment Storage

Store at room temperature (15 ° C-25 ° C). Keep out of reach of children.

Carbotriol Ointment Packaging

Packed in aluminum tube with vinyl screw cap, 15g / piece, 30g / piece.

The validity of calcipotriol ointment

24 months

Carbotriol ointment implementation standard

Import drug registration standard: JX20020150

^[1]