What Are the Different Uses of Lidocaine Cream?

Compound lidocaine cream is suitable for local cortical anesthesia for the following conditions: (1) needle puncture, such as: placing a catheter or taking a blood sample; (2) superficial surgery.

Drug Name: Compound Lidocaine Cream

Drug type: prescription

Compound lidocaine cream ingredients

This product is a compound preparation. Its components are: prilocaine and lidocaine. Each g of this product contains 25mg of prilocaine and 25mg of lidocaine.

Compound Lidocaine Cream Properties

This product is a white cream.

Compound lidocaine cream indications

This product is used for local anesthesia in the cortex:
(1) Needle puncture, such as: placing a catheter or taking a blood sample;
(2) Superficial surgery.

Compound lidocaine cream specifications

Each g contains 25mg of prilocaine and 25mg of lidocaine

Compound lidocaine cream usage dosage

For the skin: Apply a thick layer of cream on the surface of the skin, seal the cover with a film, about 1.5g / 10cm ^{2 for} adults and children over 1 year, about 2g for minor surgery, the application time is at least 1 hour, most 5 hours long, large area skin surgery is about 1.5 ~ 2g / 10cm ² , the application time is at least 2 hours, the longest is 5 hours. For infants from March to December, a maximum of 2 g of cream is applied to the skin of 16 cm2, and the application time is about 1 hour.
Genital mucosa: Apply 5 to 10 g of this product to the mucous membrane for about 5 to 10 minutes. You do not need to cover the sealing film to start the operation.

Adverse effects of compound lidocaine cream

This product can produce local reactions at the application site. Pale, erythema (redness), and edema are more common. These reactions are mostly transient and mild.
Burning or itching sensation may also occur during the initial use, but it is relatively rare.
Allergic reactions to amide local anesthetics (the most serious of which is anaphylactic shock) are rare.
High doses of prilocaine can cause increased levels of methemoglobin in the blood.

Compound lidocaine cream contraindicated

(1) Those who are highly allergic to amide local anesthetics or any other ingredients in this product;
(2) Patients with congenital or idiopathic methemoglobinemia.

Precautions for compound lidocaine cream

(1) Because there is not enough information about absorption, this product cannot be used for open wounds, nor can it be used for children's reproductive organ mucosa;
(2) Laboratory test results show that this product has an ototoxic effect when it enters the middle ear, but there is no abnormality found in the external ear canal of animals with intact tympanic membranes.
(3) This product should be used with caution when used near the eyes, because it can cause corneal irritation;
(4) Patients with atopic dermatitis need to be especially careful when using this product, and the short application time can be (15-30 minutes);
(5) Leg ulcers should be used after disinfection;
(6) The effect of anesthesia will decrease when the time is extended;
(7) This product cannot be used in the following situations until further clinical data are available:
Infants under 3 months;
Infants 3 to 12 months who are being treated with methemoglobin elicitor.

Compound lidocaine cream for pregnant and lactating women

Lidocaine and prilocaine can be absorbed by the fetus through the placental barrier. To date, many pregnant women and women of reproductive age have used lidocaine and prilocaine, but no specific disorders of the reproductive process have been reported, such as the occurrence of deformities Increased rates or other direct or indirect effects of fetal damage.
Lidocaine and prilocaine are also secreted from breast milk, and because they are secreted in small amounts, babies are not affected at therapeutic dose levels.

Compound lidocaine cream for children

Until further clinical information is available, this product cannot be used in the following situations:
Infants under 3 months;
Infants 3 to 12 months who are being treated with methemoglobin elicitor.

Compound lidocaine cream for the elderly

This product has not been tested and there are no reliable references.

Compound lidocaine cream overdose

Except for one case of methemoglobinemia reported abroad, no case of systemic poisoning of this product has been reported. If symptoms of systemic poisoning appear, their signs are similar to those of poisoning when a local anesthetic is used by other routes of administration. The toxic effects of local anesthesia are symptoms of nervous system excitement, and severe cases are symptoms of central nervous system and cardiovascular depression.
Severe neurogenic symptoms (convulsions, central nervous system depression) must be treated symptomatically through respiratory support and the use of anticonvulsants. Methaemoglobinemia can be treated by slow intravenous injection of melanin.

Compound Lidocaine Cream Pharmacology and Toxicology

This product is applied to the non-destructive skin surface and covered with a sealed film. It is achieved by releasing lidocaine and prilocaine to the subcutaneous and cortex, and accumulating lidocaine and prilocaine at the cortical nociceptors and nerve endings. Cortical anesthetic effect. Lidocaine and prilocaine are local anesthetics due to amide-type local anesthetics. They both stabilize nerve cell membranes by blocking the generation of nerve impulses and conducting the required ion current.

Pharmacokinetics of Compound Lidocaine Cream

The systemic absorption of lidocaine and prilocaine contained in this product depends on the dosage, the time of application, the thickness of the skin in different parts of the body, and other skin conditions.
For non-destructive skin: Apply the cream on the thighs of adults (60g / 400cm ² ). After 3 hours, about 5% of lidocaine and prilocaine are absorbed; the highest plasma drug concentration is reached after 2 to 6 hours, lido Caine and prilocaine average 0.12 and 0.07 g / ml, respectively.
Facial use: Use at a dose of 10g / 100cm ^2. After 2 hours, the systemic absorption is about 10%. After 1.5 to 3 hours, the maximum plasma drug concentration is reached.
Genital mucosa: 10g of this product is applied to the vaginal mucosa, and the maximum plasma drug concentration is reached after 20 to 45 minutes.

Compound Lidocaine Cream Storage

It should be sealed and stored below 25 . It should not be frozen.

Compound Lidocaine Cream Packaging

Medicinal aluminum tube.

Validity of Compound Lidocaine Cream

24 months

Compound Lidocaine Cream Standard

YBH02032006 ^[1]