What Are the Medical Uses of Atractylodes?

Stir-fried Atractylodes is a tonic medicine, which has the effects of strengthening the spleen and qi, etc. It is to sprinkle honey bran into a hot pot, add atractylodes chips when it smokes, stir-fry until it is burnt yellow, and release the burnt aroma. Sift the honey bran. For every 100kg of atractylodes tablets, 10kg of honey bran is used. ^[1]

Fried Atractylodes

Fried Atractylodes is a tonic medicine, with

Dampness, water, antiperspirant, and tocolysis. It is used for spleen deficiency, food loss, bloating and diarrhea, phlegm drink, dizziness, edema, spontaneous sweating,

1. Pharmacological effects related to efficacy indications

Atractylodes has the effects of strengthening the spleen and replenishing qi, drying dampness and water, antiperspirant, and calming the fetus. It is used for spleen deficiency and eating, bloating and diarrhea, phlegm drinking dizziness, edema, spontaneous sweating, and uneasy fetal movement. "Medicine Qiyuan" records: "Dehumidification and Yisao, moderate and beneficial qi, warm, remove spleen and stomach, remove stomach heat, strengthen the spleen and stomach, eat, quench thirst, and conceive."

(1) Impact on the digestive system

The effect of Atractylodes decoction on gastrointestinal motor function on isolated bowel movements of rabbits is related to the functional state of the bowel. Under normal circumstances, it has an excitatory effect. When the bowel is in an excited state by the action of acetylcholine, Atractylodes has an inhibitory effect. When the intestine is in an inhibited state by the action of adrenaline, Atractylodes has an excitatory effect, which can restore the intestinal activity to close to Normal level. Pigment dextran blue 2000 was used as a gastrointestinal marker, and it was confirmed that Atractylodes macrocephala decoction significantly promoted gastric emptying and small intestine advancing function in mice. Intragastric administration of Atractylodes macrocephala decoction has a significant effect on promoting the movement of charcoal glue in the small intestine of mice. Atropine can obviously inhibit the effect of Atractylodes macrocephala on intestinal excitability. It is speculated that the effect of excitatory intestinal motion is mainly produced by excitement of M-choline receptors. Atractylodes decoction has an excitatory effect on gastrointestinal movement, while atractylodes volatile oil has an inhibitory effect. Atractylodes volatile oil has a strong effect on inhibiting the spontaneous movement of the intestinal canal and antagonizing barium chloride, while juniper in volatile oil has a stronger effect on acetylcholine.

Anti-ulcer Atractylodes acetone extract was administered orally and had a significant inhibitory effect on gastric mucosal damage in rats induced by hydrochloric acid-ethanol. Duodenal administration can inhibit gastric secretion in pyloric-ligated rats, reduce gastric acidity, and reduce gastric acid and pepsin excretion.

Gavage of Atractylodes macrocephala decoction in liver-protecting mice can prevent liver damage caused by carbon tetrachloride, reduce liver glycogen reduction and liver cell degeneration and necrosis, promote liver cell growth, and decrease elevated ALT.

(2) Enhance the body's immune function

Atractylodes can significantly enhance the ability of white blood cells to engulf S. aureus. Atractylodes polysaccharide can activate alone or in conjunction with ConA and PHA in a certain concentration range to promote normal mouse lymphocyte transformation and significantly increase the level of IL-2 secretion. Hydrocortisone causes immunosuppression in mice, Atractylodes polysaccharide has a role in restoring lymphocyte proliferation function, and improves the survival rate of spleen cells of immunosuppressed mice in vitro, prolongs the life span of lymphocytes, and corrects the disorder of T cell subgroup distribution State, can significantly lower the level of IL-2.

(3) Anti-stress

Atractylodes has anti-fatigue and enhances adrenal function. The mice were given gastric atractylodes decoction daily for 1 month, which could increase body weight, increase physical strength, and prolong swimming time. Intragastric administration of Atractylodes macrocephala decoction can also enhance the physical strength and prolong the swimming time of tumor-bearing (cervical cancer U14) mice.

(4) Enhance hematopoietic function

Atractylodes can promote erythrocyte hematopoiesis in mice. Subcutaneous injection of Atractylodes macrocephala decoction for 3 days in mice significantly promoted erythroid hematopoietic progenitor cells.

(5) Diuretic

Rats, rabbits, large intragastric administration or intravenous injection of Atractylodes macrocephala or fluid extract have obvious and lasting diuretic effects, and can promote the excretion of electrolytes, especially sodium. Intravenous injection of atractylodes decoction in non-anesthetized dogs increased the urine output by 9 times and the effect lasted for 5 hours. Gavage administration increased the urine output by 2-3 times and the effect lasted for 6-7 hours. Atractylodes does not affect the antidiuretic effect of posterior pituitary. The diuretic mechanism of Atractylodes may be related to inhibiting electrolyte reabsorption and increasing the excretion of Na +, K +, CI-.

(6) Inhibit uterine contraction

The effectiveness of Atractylodes abortus is related to its ability to inhibit uterine contractions. The alcoholic extract and petroleum ether extract of Atractylodes macrocephala significantly inhibited the spontaneous contraction of the uterus of infertile mice and the excitatory contraction of the uterus induced by oxytocin and motherwort, and the inhibitory effect increased with increasing drug concentration There is a dose-effect relationship. Albacol extract can also completely antagonize the oxytocin's contraction of guinea pigs' pregnant uterus in vivo. Atractylodes alcohol extract has stronger inhibitory effect on isolated uterus, but water extract has weaker inhibitory effect.

(7) Antioxidant and delay aging

Atractylodes has antioxidant effects. It can effectively inhibit lipid peroxidation, reduce the content of tissue lipid peroxides, avoid damage to the structure and function of tissue cells by harmful substances, and can resist autooxidative hemolysis of mice and human red blood cells. Atractylodes can increase the SOD activity of red blood cells in mice over 12 months of age, enhance the effect of scavenging oxygen free radicals, reduce the damage of oxygen free radicals to the body, and inhibit the activity of mouse brain monoamine oxidase B. Gavage of Atractylodes macrocephala decoction for 4 weeks in aged mice can significantly increase the activity of whole blood GSH-Px and significantly reduce the content of MDA in red blood cells. Atractylodes has the effect of delaying the aging of kidneys in aged mice, and can significantly improve the kidney structure of aged mice.

2. Other pharmacological effects

(1) Hypoglycemic rabbits ingesting atractylodes decoction can accelerate the oxidative utilization of glucose in the body and have a hypoglycemic effect.

(2) The prothrombin time of anticoagulant rats was prolonged significantly after gavage of Atractylodes macrocephala. After taking Atractylodes macrocephala or ethanol extract, healthy people's prothrombin time and clotting time were significantly prolonged.

(3) Anti-tumor atractylodes has cytotoxic effect on tumor cells, can reduce the proliferation rate of tumor cells, reduce the invasiveness of tumor tissues, and improve the body's ability to resist tumor responses. Atractylodes volatile oil has inhibitory effects on Ehrlich ascites cancer, lymphosarcoma ascites type, esophageal cancer (Ecal09), and sarcoma 180 in mice. Intraperitoneal injection of atractylodes B on mouse sarcomas. There is also a significant inhibitory effect.

In summary, the pharmacological effects related to the efficacy of Atractylodes spleen and strengthening qi are regulating gastrointestinal motility, anti-ulcer, liver protection, enhancing the body's immune function, anti-stress, enhancing hematopoiesis, etc .; its effects of dryness, dampness, and water retention and The diuretic effect is related to the effect of abortion related to the inhibition of uterine contraction. Atractylodes also has anti-oxidant, anti-aging, hypoglycemic, anticoagulant, antitumor and other effects.