What Are the Medical Uses of Bromhexine?

In clinical applications, bromhexine is more suitable for chronic obstructive pulmonary diseases such as chronic bronchitis, emphysema, and bronchiectasis. Especially when the sticky sputum blocks the small bronchus and causes shortness of breath or asthma, bromhexine can be taken orally, inhaled by inhalation or instilled in the trachea ^[1] .

Drug type: Essential medicines
Drug name: Bromhexine

English name: Bromhexine
Chinese alias: Bromohexylamine; expectorant; bromobenzylcyclohexylamine
English alias: Bisolvon; Broncokin

Bromhexine compounds

Bromhexine Basic Information

Chinese name: Bromhexine

Chinese alias: 2-amino-3,5-dibromo-N-cyclohexyl-N-methylbenzylamine; N-methyl-N-cyclohexyl-2-amino-3,5-dibromobenzylamine; Bisopine; Bromhexylamine; Must be expectorant; Bromhexyl bromide; Bromhexyl hydrochloride; Bromhexyl bromide; Bromhexyl

English name: bromhexine

English alias: 2-amino-3,5-dibromo-N-cyclohexyl-N-methylbenzenemethanamine; Bromhexinum [INN-Latin]; Bromhexina [INN-Spanish]; Benzenemethanamine, 2-amino-3,5-dibromo-N-cyclohexyl -N-methyl; N- (2-amino-3,5-dibromo-benzyl) -N-methyl-cyclohexylamine; Bisolvon

CAS number: 3572-43-8

Molecular formula: C ₁₄ H ₂₀ Br ₂ N ₂

Structural formula:

Molecular weight: 376.13000

Exact mass: 373.99999

PSA: 29.26000

LogP: 5.13950

Bromhexine physicochemical properties

Density: 1.57 g / cm ³

Boiling point: 413.8ºC at 760 mmHg

Flash point: 204.1ºC

Refractive index: 1.626

Melting point 239 243

This product is a semi-synthetic product obtained by structural transformation of vasicine, and its hydrochloride is commonly used. It is white or almost white crystalline powder; odorless and tasteless. It is slightly soluble in ethanol or chloroform and very slightly soluble in water.

Bromhexine Safety Information

Customs code: 2921590090 ^[2]

Bromhexine Pharmacopoeia Standard

[Identification] (1) In the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution. (2) The infrared absorption spectrum of this product should be consistent with the control spectrum (spectrum set 402). (3) Take about 10mg of this product, add 1ml of ethanol, and dissolve it slightly with heat. The solution shows the identification reaction of aromatic first amines (Appendix III). (4) Take 10mg of this product, add 2ml of ethanol, and dissolve slightly heat, the solution shows a chloride identification reaction (Appendix III).

[Inspection] Take this product, weigh it accurately, add methanol to dissolve and dilute it to make a solution containing about 2.5mg per lml, as the test solution; take an appropriate amount, and dilute with methanol to make each 5 g of the solution was used as a control solution. According to the chromatographic conditions under the content determination item, take 10 g of the control solution, inject it into the liquid chromatograph, and adjust the detection sensitivity so that the peak height of the chromatographic peak of the main component is about 20% of the full range; and then accurately measure the test solution and the control. Each 10 l of the solution was injected into a liquid chromatograph, and the chromatogram was recorded to three times the peak retention time of the main component. If there is an impurity peak in the chromatogram of the test solution, the area of a single impurity peak must not be greater than the area of the main peak of the control solution (0.2%), and the sum of the area of each impurity peak must not be greater than 1.5 times (0.3%) of the area of the main peak of the control solution. Loss on drying: Take this product and dry to constant weight at 105 ° C. Lose weight should not exceed 0.5% (Appendix L). Ignition residue of l.Og of this product, check according to law (Appendix N), the residual residue should not exceed 0.1%. The heavy metal shall be taken as the residue left under the burning residue, and shall be inspected in accordance with the law (Appendix H Second Law). The content of heavy metal shall not exceed 20 parts per million.

[Content determination] According to high performance liquid chromatography (Appendix VD). Chromatographic conditions and system suitability test. Octadecylsilicon-bonded silica gel was used as a filler; potassium dihydrogen phosphate buffer solution (take 1.0 g of potassium dihydrogen phosphate, add 900 ml of water to dissolve, and use 0.5 mol / L hydroxide The sodium solution was adjusted to pH 7.0 and diluted with water to 1000 ml) -acetonitrile (20:80) as the mobile phase; the column temperature was 40 ° C; the detection wavelength was 245 nm. The resolution of bromhexine hydrochloride peak and adjacent impurity peaks should meet the requirements. Take the appropriate amount of the product by measurement, accurately weigh, add methanol to dissolve and quantitatively dilute to make a solution containing about 0.5mg per ml. As a test solution, take a precise amount of 10l, inject the liquid chromatograph, and record the chromatogram Another reference substance, bromhexine hydrochloride, was measured in the same way. Calculate the peak area according to the external standard method, that is, get it.

[Category] Expectorant.

[Storage] Keep sealed.

Bromhexine drug description

Bromhexine Classification

Respiratory Drugs> Expectorant Drugs> Drugs That Decrease Sputum Adsorption

Bromhexine dosage form

1. Tablet: 8mg;

2. Injection: 4mg (2ml).

Bromhexine pharmacological action

This product has a strong sputum dissolving effect. It mainly acts on mucus-producing cells of the trachea and bronchial mucosa, inhibits the synthesis of acidic mucopolysaccharide protein in sputum, and can break the mucin fibers in sputum. Therefore, the rheological characteristics of trachea and bronchi are restored to normal, and mucus Reduced, diluted sputum is easy to cough. The expectorant effect of this product is also related to its promotion of ciliary movement of the respiratory tract mucosa and its nauseous expectorant effect. It takes about 1 hour after taking the medicine, the effect reaches a peak in 4 to 5 hours, and the effect is maintained for 6 to 8 hours.

Bromhexine pharmacokinetics

Bromhexine is effective 1 hour after oral administration, and the effect is strongest in 3 to 5 hours, which can be maintained for 6 to 8 hours. Most of the degradation is converted into metabolites and excreted with urine, and only a few are excreted by feces.

Bromhexine indication

For chronic bronchitis, asthma, bronchiectasis, silicosis and other patients with white sticky sputum and difficult to cough. Patients with purulent sputum need antibiotics to control infection.

Bromhexine dosage

1. 2 to 3 times a day, 8 to 16 mg each time.

2. Subcutaneous, intramuscular, intravenous or intravenous drip: 1 to 2 times a day, 4 to 8 mg each time. 20% to 40ml of 25% dextrose injection for intravenous injection is diluted slowly after injection. Intravenous infusion is diluted slowly with 250-500ml of 5% glucose saline or Ringer's solution.

3. Inhalation: 0.2%, 1 to 3 times a day, 2ml each time.

Bromhexine adverse reactions

Occasionally nausea and upset stomach can disappear after reduction or withdrawal. The serious adverse reactions were rash and enuresis.

Bromhexine contraindications

Those who are allergic to this medicine are prohibited.

Bromhexine precautions

1. Use with caution in patients with gastric ulcers.

2. Use with caution in pregnant and lactating women.

3. Patients with purulent sputum need antibiotics to control infection.

4. Bromhexine should be taken after meals.

Bromhexine drug interactions

This product can increase the distribution concentration of amoxicillin and tetracycline antibiotics in the lungs or bronchial tubes, and when combined, can enhance the antibacterial efficacy.

Bromhexine poisoning

Bromhexine (bromohexyl ammonium, bisulfin) has a strong role in dissolving sputum, making the sputum thinner and easy to discharge; it can also promote the cilia movement of the respiratory mucosa and have a nausea expectorant effect. Completely absorbed by mouth, for those with thick sputum and difficult to cough. Can stimulate the gastrointestinal mucosa and activate the collapse

Bromhexine

Tablet: 8mg

Bromhexine Expert Reviews

Bromhexine Hydrochloride Tablets

Indications: This product is mainly used in patients with chronic sputum stickiness caused by chronic bronchitis and asthma.

Dosage: Oral. Adults, 1 or 2 tablets at a time, 3 times a day.

Dosage form: tablet

Adverse reactions: occasional nausea and upset stomach. May temporarily increase serum transaminase.

Contraindications: Unclear.

Note: 1. This product is irritating to the gastrointestinal mucosa. Use with caution in patients with gastritis or gastric ulcer.

2. Patients with liver dysfunction should be used under the guidance of a physician.

3, those who are allergic to this product are prohibited, those with allergies should be used with caution.

4. It is forbidden to use this product when its properties change.

5. Please keep this product out of the reach of children.

6. Children must use under adult supervision.

7. If you are using other medicines, please consult your doctor or pharmacist before using this product.

Ingredients: Each tablet of this product contains 8 mg of bromhexine hydrochloride. The excipients are starch, dextrin and magnesium stearate.

Properties: This product is a white tablet.

Function category: This product is an over-the-counter medicine such as expectorants.

Drug interactions: 1. This product can increase the efficacy of tetracycline and amoxicillin.

2. Drug interaction may occur if used with other drugs at the same time, please consult your doctor or pharmacist for details.

Pharmacological effect: This product directly acts on the bronchial glands, which can release the lysosomes of mucus-secreting cells, thereby dissolving the mucopolysaccharides in the mucus and reducing the viscosity of the mucus. The molecular mucin makes the sputum thin and easy to cough ^[3] .

Storage: sealed.

Drug validity: 36 months

Implementation standard: "Chinese Pharmacopoeia" 2010 edition two.

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