What Are the Medical Uses of Isatis Tinctoria?

"Banlangen" is deeply rooted in the hearts of the people. It is because it has done a great job in eradicating the SARS virus. (In the current period of the spread of a flu, Banlangen is one of the first choice Chinese herbal medicines). At least 80% of China s 1.3 billion people understand the efficacy of isatis root.

Banlangen

Most are caused by Banlangen injection, manifested as dizziness,

Banlangen antibacterial and antiviral

Isatis root has effects on a variety of bacteria. Aqueous extracts have inhibitory effects on Bacillus subtilis, Staphylococcus aureus, octococcus, E. coli, typhoid, paratyphoid, bacillary dysentery (Shigella, Freundi), enterobacteria, etc .; acetone extracts are similar Effect, and effective on hemolytic streptococci (both agar plate method). The antibacterial effect on type A meningococci is similar to that of garlic and honeysuckle. Antibacterial and antiviral active ingredients of Isatis indigotica and Daqing Ye are considered to be indigoside. Experiments have shown that indigoside has no antibacterial effect in vivo and in vitro; the antiviral effect is not prominent in vitro; it is excreted quickly in vivo, so it is considered that it has no obvious physiological and antibacterial activity. Its active ingredients are yet to be studied. ^[1]

Banlangen anti-leptospira

Isatis indigotica or large green leaves of more than 100 have the function of killing Leptospira in the test camp.

Detoxification

It has been reported that canine root, Coptis chinensis powder, and veratrum can be taken together with dogs (2.0g / kg each), which can detoxify veratrum and reduce mortality. Coptis powder, the effect is not good.

Banlangen boosts immunity

Intraperitoneal injection of isatis root polysaccharide 50mg / kg in mice can significantly promote the immune function of mice, which can significantly increase the spleen weight of normal mice. The total number of white blood cells and the number of lymphocytes has a significant counteracting effect on the reduction of the spleen index, the total number of white blood cells and the number of lymphocytes in immunosuppressed mice induced by hydrocortisone; it significantly enhances the normal caused by dinitrochlorobenzene and the Delayed hypersensitivity reaction in immunosuppressed mice; enhances the percentage of ANAE positive in peripheral blood lymphocytes of normal mice, and obviously counteracts the immunosuppressive effect caused by hydrocortisone; There was no significant enhancement in rat spleen cell leaching response. In addition, Radix Isatidis polysaccharides can significantly enhance the function of antibody-forming cells and increase the rate of carbon particle clearance in mice injected intravenously.

Antitumor effect of Banlangen

W256 solid tumors in rats and Lewis lung cancer in mice were injected with indigo red 200 mg / kg for 6-7 days. The results showed that the inhibition rates of W256 solid tumors in rats were 47-50% and 50-58%, respectively. When it is reduced below 100 mg / kg per day, its inhibitory effect is not obvious. Indirubin 500 mg / kg was administered intragastrically, and the inhibition rate on solid tumors of rats W256 was 23-33%, and the inhibition rate of mouse sarcomas 180 was about 30%. Indigo red can prolong the survival time of lymphatic leukemia L7212 mice by about 20%. In addition, the mouse spermatogonia test proved that indirubin cannot specifically inhibit type B spermatogonia and sperm cells.

Effect of Banlangen on Leukemia

Pharmacological studies have initially shown that indirubin can destroy leukemia cells. From the perspective of ultrastructure, degeneration and necrosis cells were mostly swollen and lytic necrosis under the action of indirubin. It was found in the experiment that indirubin can enhance the phagocytic capacity of the animal's mononuclear macrophage system. The mononuclear macrophage system plays a certain role in the body's immune response, so the anti-cancer effect of indigo red may be related to improving the body's immune capacity.