What Are the Medical Uses of Magnesium Salicylate?

Magnesium salicylate (Magnesium salicylate) chemical name is bis (2-hydroxybenzoic acid-O1, O2) magnesium tetrahydrate, which is white crystals, has no odor, or is a crystalline powder, which is easy to weather. Soluble in ethanol, stable at normal temperature and pressure, molecular formula is C14H10MgO6, and molecular weight is 298.53100. The boiling point is 336.3ºC at 760 mmHg. Intermediate for magnesium salt of choline salicylate. Used medically as an anti-infective.

Magnesium salicylate (Magnesium salicylate) chemical name is bis (2-hydroxybenzoic acid-O1, O2) magnesium tetrahydrate, which is white crystals, has no odor, or is a crystalline powder, which is easy to weather. Soluble in ethanol, stable at normal temperature and pressure, molecular formula is C14H10MgO6, and molecular weight is 298.53100. The boiling point is 336.3ºC at 760 mmHg. Intermediate for magnesium salt of choline salicylate. Used medically as an anti-infective.

Chinese name

Magnesium salicylate

Foreign name

Magnesium Salicylate

CAS number

18917-95-8

EINECS number

242-669-3

Molecular formula

C14H10MgO6

Molecular weight

298.53

Water soluble

Slightly soluble in water

Aqueous solution

Acidic

LogP

2.02660

Brief Introduction of Magnesium Salicylate

Magnesium Salicylate Basic Information

Chinese name: magnesium salicylate

English name: Magnesium salicylate

CAS number: 18917-89-0

Molecular formula: C ₁₄ H ₁₀ MgO ₆

Molecular weight: 298.53100

Structural formula:

Exact mass: 298.03300

PSA: 93.06000

LogP: 2.02660 ^[1]

Physicochemical properties of magnesium salicylate

Boiling point: 336.3ºC at 760 mmHg

Flash point: 144.5ºC

Vapor pressure: 4.45E-05mmHg at 25 ° C ^[1]

Use of magnesium salicylate

It has anti-inflammatory, antipyretic and analgesic effects. It is used in rheumatoid arthritis, connective tissue disease, joint pain and rheumatic pain, and also used in bursitis. ^[1]

Preparation method of magnesium salicylate

After 276 g (2 mol) of salicylic acid was uniformly mixed with 84 g (1 mol) of magnesium carbonate, 200 mL of water was added to the above reaction mixture in small portions, and the reaction was carried out by heating and shaking on a water bath. After carbon dioxide almost no longer occurs, add an appropriate amount of hot water to completely dissolve it, filter while it is hot, and then cool it down to collect the precipitated magnesium salicylate tetrahydrate crystals.

Calculated Chemical Data for Magnesium Salicylate

1. Number of hydrogen-bonded donors: 4

2. Number of hydrogen bond acceptors: 10

3. Number of rotatable chemical bonds: 0

4. Topological molecular polar surface area (TPSA): 130

5. Number of heavy atoms: 25

6. Surface charge: -2

7. Complexity: 303

8. Number of isotope atoms: 0

9. Determine the number of atomic stereocenters: 0

10. Uncertain number of atomic stereocenters: 0

11. Determine the number of chemical bond stereocenters: 0

12. Uncertain number of chemical bond stereocenters: 0

13. Number of covalent bond units: 7 ^[2]

Hazard statement for magnesium salicylate

It is generally slightly harmful to water bodies. Do not expose undiluted or large quantities of products to groundwater, waterways or sewage systems. Do not discharge materials into the surrounding environment without government permission. ^[2]

Storage method of magnesium salicylate

Sealed at room temperature and protected from light, ventilated and dry. ^[2]

Pharmacopoeia Standard for Magnesium Salicylate

The main active ingredient of magnesium salicylate

Bis (2-hydroxybenzoic acid-O, O) magnesium tetrahydrate. Calculated on dry basis, C14H10MgO6 should be 98.0% 103.0%.

Magnesium salicylate

White crystalline powder; odorless; weathering; micro acid reaction in aqueous solution. Soluble in ethanol, soluble in water. ^[3]

Identification of magnesium salicylate

(1) Take the solution of the test product under the content determination item, and measure it according to the ultraviolet-visible spectrophotometry. It has the maximum absorption at the wavelength of 296nm.

(2) The infrared absorption spectrum of this product should be the same as that of the control ("Infrared Spectra of Drugs" 60).

(3) The identification reaction between the magnesium salt and salicylate in the aqueous solution of this product. ^[3]

Magnesium Salicylate

magnesium

Take about 0.8g of this product, accurately weigh it, put it in a 200ml measuring bottle, add an appropriate amount of water, shake it for 15 minutes, then dilute to the mark with water, shake well, filter, and accurately take 50ml of the filtrate and place it in a 250ml conical bottle Add 50ml of water, 5ml of ammonia-ammonium chloride buffer (pH10.0) and chrome black T indicator a little, titrate with ethylenediamine tetraacetic acid disodium titration solution (0.05mol / L), until the solution changes from purple-red to Pure blue. Each 1ml of ethylenediamine tetraacetic acid disodium titration (0.05mol / L) is equivalent to 1.215 mg of magnesium. Based on the dry product, the magnesium content should be 7.9% to 8.3%. ^[3]

Loss on drying

Take this product and dry it at 105 for 4 hours. The weight loss should be 17.5% 20.0%.

Heavy metal

Take 0.50g of this product, add 20ml of water to dissolve it, add 2ml of acetate buffer solution (pH3.5) and water to 25ml, and check according to law that the content of heavy metals must not exceed 40 parts per million. ^[3]

Determination of magnesium salicylate

Take this product, accurately weigh it, add water to dissolve and quantitatively dilute it to make a solution containing about 20 g of anhydrous salicylate per 1ml; take another reference of magnesium salicylate, accurately weigh, dissolve and quantitatively dilute with water to make each Approximately 20 g of solution is contained in 1 ml. Take the above two solutions, and measure the absorbance at the wavelength of 296nm according to the ultraviolet-visible spectrophotometry, and calculate. ^[3]

Magnesium salicylate

(1) magnesium salicylate tablets (2) magnesium salicylate capsules

Analysis of Magnesium Salicylate

Method name: Magnesium Salicylate API-Determination of Magnesium Salicylate-Spectrophotometric Method

Scope of application: This method uses spectrophotometry to determine the content of magnesium salicylate in raw materials of magnesium salicylate.

This method is applicable to raw materials of magnesium salicylate.

Principle of the method: The test sample is dissolved in water and quantitatively diluted to prepare a test solution. An ultraviolet-visible spectrophotometer is set, and the absorbance is measured at a wavelength of 296 nm to calculate the content.

Reagent: water

Equipment: UV-visible spectrophotometer

Sample preparation: 1. Preparation of reference solution

Accurately weigh an appropriate amount of magnesium salicylate reference substance, dissolve it with water and quantitatively dilute it to make a solution containing about 20 mg of magnesium salicylate per 1 mL to obtain a reference solution.

2. Preparation of test solution

Weigh the test product precisely, add water to dissolve and quantitatively dilute it to make a solution containing about 20 mg of magnesium salicylate per 1mL, to obtain the test solution.

Note: "Precision weighing" means that the weighing weight should be accurate to one thousandth of the weighing weight. "Precision measurement" means that the accuracy of measuring the volume should meet the accuracy requirements of the volume pipette in national standards.

Operation steps: Take the reference solution and the test solution according to ultraviolet spectrophotometry, and measure the absorbance at a wavelength of 296nm.

Note: The spectrophotometric method should be based on the same batch of solvent prepared as the test product, using a 1cm quartz absorption cell. The wavelength with the largest absorbance is used as the measurement wavelength. Generally, the error of the absorbance reading of the test product is between 0.3-0.7. The slit band width of the instrument should be less than half the width of the absorption band of the test product, otherwise the measured absorbance is low. The selection of the slit width should be based on reducing the absorption of the test article when the slit width is reduced. Because the absorption cell and the solvent may have blank absorption, the blank reading should be subtracted after measuring the absorbance of the test product, and the content should be calculated. ^[3]

Salicylate Compound Drug Description

Name of magnesium salicylate :

[Common name] Magnesium salicylate

[English name] Magnesium Salicylate Tablets

[Chinese Pinyin] Shui Yang Suan Mei Pian ^[4]

Magnesium salicylate

Chemicals & Biological Products >> Antipyretic Analgesic Anti-inflammatory Drugs >> Organic Acids >> Carboxylic Acids

Magnesium Salicylate Properties:

This product is a white tablet. ^[4]

Pharmacology and toxicology of magnesium salicylate :

This product is a non-steroidal antipyretic and analgesic, which has antipyretic, analgesic and anti-inflammatory effects. 545mg of this product is equivalent to the salicylic acid content of 650mg aspirin. Has little effect on platelet aggregation. ^[4]

Pharmacokinetics of magnesium salicylate :

1. In vivo process: (1) absorption is rapid and complete after oral administration. Absorption and solubility are related to gastrointestinal pH. Food reduces the rate of absorption, but does not affect the amount absorbed. Enteric-coated tablets absorb slowly. This product absorbs quickly when taken with sodium bicarbonate. After absorption, it is distributed in various tissues and penetrates into the joint cavity and cerebrospinal fluid. (2) Aspirin has a low protein binding rate, but the salicylate protein binding rate after hydrolysis is 65% to 90%. The distribution volume for adults reaches 170ml / kg. When the blood concentration is high, the binding site on the protein will be saturated, and the distribution volume will increase. t1 / 2 is 15 to 20 minutes. The t1 / 2 length of salicylate depends on the size of the dose and the pH of the urine. It is about 3.1 to 3.5 hours in a small dose; it can reach 9 hours in a large dose (1g). See extension. After oral administration of 0.65 g of aspirin, t1 / 2 of salicylate in milk was 3.8 to 12.5 hours. (3) Most of this product is quickly hydrolyzed to salicylate in the gastrointestinal tract, liver and blood; then it is metabolized in the liver. The metabolites are mainly salicylic acid and glucuronic acid conjugates, a small part of which is oxidized to gentisic acid (gentiSicacid). (4) Most of this product is excreted in urine with bound metabolites and a small part with free salicylic acid. When the dose is large, excretion of unmetabolized salicylic acid increases. Individuals can vary greatly. The pH of urine has an effect on the rate of excretion. It is excreted faster in alkaline urine, and the amount of free salicylic acid increases, but the opposite is true in acid urine. 2. Medication Notes: (1) Should be taken with food to reduce gastrointestinal irritation. (2) Surgical patients should be discontinued 5 days before surgery to avoid causing coagulopathy. (3) When used for the treatment of arthritis, the dose should be gradually increased until the symptoms are relieved, and the dose should be reduced after reaching the effective blood concentration; however, the dosage should not be adjusted frequently, generally not more than once a week; salicylic acid blood It usually takes 7 days for the drug concentration to reach steady state. (4) Excessive sweating in children, the elderly or frail patients can easily lead to collapse; patients who have already been dehydrated (especially children) should reduce the dose. (5) Treatment in case of overdose: including induce vomiting or gastric lavage, give activated charcoal, correct high fever, water-electrolyte acid-base imbalance and ketosis, etc., maintain normal blood sugar, monitor salicylate blood concentration below toxic level. Giving a large amount of alkaline medicine to diuretic can promote excretion of this product, but sodium bicarbonate should not be given orally. Severe overdose can consider hemodialysis or abdominal dialysis. If bleeding, give vitamin K, transfusion if necessary. ^[4]

Indications for magnesium salicylate :

It is used to treat various arthritis, because it does not contain sodium ions, especially suitable for patients with hypertension or heart failure. Can also be used for bursitis and other soft tissue rheumatism. ^[4]

Magnesium Salicylate Usage and Dosage:

Oral administration: The usual dosage for adults: 0.5 1g once, 3 times a day. If necessary, the dosage can be increased to achieve the desired effect. The maximum daily dose is 3 4g. ^[4]

Adverse reactions of magnesium salicylate :

A few patients have upper abdominal discomfort, nausea, and occasionally tinnitus and dizziness. ^[4]

Magnesium Salicylate Contraindications:

Patients with liver and kidney dysfunction and active peptic ulcer are contraindicated. Myasthenia gravis is disabled. ^[4]

Notes on magnesium salicylate :

1. Cross-allergic reactions. Allergic to this product may also be allergic to another salicylic acid or another non-salicylic non-steroidal anti-inflammatory drug. But not absolutely. The possibility of cross-allergies must be watched.

2. Interference to diagnosis:

(1) When the long-term daily dosage exceeds 2.4g, the copper sulfate urine glucose test may appear false positive, and the glucose enzyme urine glucose test may appear false negative;

(2) Can interfere with urine ketone test;

(3) When the blood drug concentration exceeds 130 g / ml, the false high value can be obtained by measuring the blood uric acid with the colorimetric method, but the urase method is not affected;

(4) It can be interfered by this product when measuring 5-hydroxyindoleacetic acid (5-HIAA) by fluorescence method;

(5) The determination of urine vanillyl mandelic acid (VMA) can be high or low due to different methods used;

(6) As this product inhibits platelet aggregation, it can prolong bleeding time. Dose as small as 40mg / day can also affect platelet function, but there have been no clinical reports of small doses (<150mg / day) causing bleeding;

(7) Liver function test, when the blood drug concentration is> 250 g / ml, alanine aminotransferase, aspartate aminotransferase, and serum alkaline phosphatase may be abnormally changed, and it may return to normal when the dose is reduced;

(8) For large-dose applications, especially when the blood concentration is> 300 g / ml, the prothrombin time can be prolonged;

(9) Serum cholesterol is low when the daily dosage exceeds 5g;

(10) As this product acts on the renal tubules, it increases the excretion of potassium, which can lead to a decrease in blood potassium. When this product is used in large doses, the serum thyroxine (T4) and triiodothyroxine (T3) can be obtained by radioimmunoassay. Lower results; (1) Due to the competitive excretion of this product with phenolsulfophthalein in the renal tubules, the excretion of phenolsulfophthalein is reduced (ie, PSP excretion test)

3 The following situations should be used with caution:

(1) When there is asthma and other allergic reactions;

(2) Those with glucose-6-phosphate dehydrogenase deficiency (this product occasionally causes hemolytic anemia);

(3) Gout (this product can affect the effects of other uric acid drugs, which may cause uric acid retention at low doses);

(4) Hepatic dysfunction can aggravate liver toxic reactions and aggravate bleeding tendency. Patients with liver dysfunction and cirrhosis are prone to kidney adverse reactions;

(5) Cardiac insufficiency or hypertension, which may cause heart failure or pulmonary edema when used in large amounts;

(6) Risk of aggravating renal toxicity during renal insufficiency;

(7) Those with thrombocytopenia.

4 Regular long-term use of drugs should be checked for hematocrit, liver function and serum salicylic acid content.

5. Attention should be paid to the risk of hypermagnesemia in patients with chronic renal insufficiency. Serum magnesium content should be monitored when a large amount of this product is used. ^[4]

Magnesium salicylate overdose:

In addition to the general toxicity of aspirin, it can also cause hypermagnesemia, which can cause skeletal muscle paralysis and respiratory depression in severe cases. ^[4]

Magnesium Salicylate Expert Reviews

Magnesium salicylate has analgesic, antipyretic and anti-inflammatory effects similar to aspirin. For in vivo processes, see Aspirin for indications. The drug has fewer side effects and is easier for patients to accept. However, when using this medicine, we must pay attention to five of the medication instructions. ^[5]