What Are the Medical Uses of Saussurea?

Xuelian injection is a prescription medicine that can relieve inflammation, relieve pain, reduce swelling, and promote blood circulation. For acute and chronic rheumatoid arthritis, rheumatoid arthritis and joint pain caused by osteoarthritis.

Snowdrop injection

(Snow Lotus Injection)

Xuelian Injection is a prescription medicine that can relieve inflammation, relieve pain, and reduce swelling.

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Study on anti-adjuvant arthritis and immune function of Xuelian injection (S) in rats, and provide pharmacological reference for its clinical application. Methods Adjuvant arthritis was induced by Freundi's complete adjuvant injection in rats. MTT assay was used to detect the proliferation of T and B lymphocytes in mice, and serum hemolysin was determined using sheep red blood cell immunoassay. Results The right hind plantar of rats injected with adjuvant began to swell from day 2 and lasted to 22 d (primary damage); the left hind plantar of adjuvant did not swell from day 6 and continued to 20 d ( Secondary damage); the degree of swelling was significantly different from the NS group. Rat im0.2,0.4,0.8 mL · kg ^ -1 · d ^ -1 S, 22 days. It can inhibit the primary and secondary damage of adjuvant arthritis in rats. From the 6th day, the swelling degree of joints is significantly reduced (P <0.05 or P <0.01). S is 1: 32 1 : Promoting the proliferation of T lymphocytes in the range of 256 dilutions (P <0.01); significantly inhibiting the proliferation of B lymphocytes in the same concentration range (P <0.01). 0.25, 0.50, 1.00 mL · kg ^ -1 · d ^ -1 of S, im, 8 d can significantly reduce the formation of serum hemolysin (P <0.01). Conclusion Xuelian injection has anti-adjuvant arthritis and immunomodulatory effects in rats.

Study on the pharmacological effects of Xuelian injection, providing a pharmacological basis for its clinical application. Methods: The anti-inflammatory and analgesic effects of Xuelian injection were observed by chemical inflammation and hot plate method, and the content of IL-1 was determined by ^ 3H-TDR incorporation method. Results: With the content index of flavonoids in snow lotus, the snow lotus injection was 50, 100, 150 mg / kg. d3, ip, significantly inhibit the swelling of the plantar foot caused by carrageenan in rats, which can significantly prolong the pain latency of mice; in vitro tests can reduce the production of IL-1 by peritoneal macrophages stimulated by LPS.

Study on the animal experiment of Xuelian injection in the treatment of pain and observe the clinical effect, there is no significant difference compared with Corning Ketong A group (P> 0.05). The snow lotus injection was injected through the catheter into the epidural space of 15 healthy adult dogs once a day, 4 ml each time, for 7 consecutive days. Another 20 healthy adult rabbits were exposed with the sciatic nerve on the side, and 1 ml of snow lotus injection was sprayed and the incision was sutured. . After two months, the materials were collected according to the requirements of light and electron microscopy. Light and electron microscope results showed that Xuelian injection had no pathological changes in the spinal cord and sciatic nerve of dogs and rabbits. Clinical observations were performed. 60 patients with periarthritis and 40 patients with lumbago and leg pain were treated with suprascapular nerve block and psoas major groove block with Xuelian injection. The effect was good. Significant difference (P> 0.05), can be used for pain treatment.

To explore the effect of Xuelian injection on the metabolism of oxygen free radicals in knee osteoarthritis model animals, and to explore the mechanism of Xuelian injection in treating osteoarthritis. Methods: Animal models of osteoarthritis were established. Animals were randomly divided into 4 groups. Groups A, B, and C were modeled by the Hulth method. Group D was the normal control group. After modeling, Group A and Group B were injected with Xuelian injection and normal saline, while Group C was blank. Five rabbits were randomly selected from each group at 6, 12, and 24 weeks after operation. Blood samples were taken to determine the content of nitric oxide (NO, Nitric oxide) in the serum. Then they were sacrificed by anesthesia and the right knee joint cavity was opened. Take out the synovial membrane and measure the activity of superoxide dismutase (SOD, Superoxide dismutase) and the content of malondialdehyde (MDA, Malondialdehyde) in the synovial tissue. Results: Except for group D, the NO content in serum at 12 weeks was higher than that at 6 weeks; the NO content in serum was higher at 12 weeks than at 12 weeks. The expression of NO gradually increased, indicating that NO is an important medium involved in the pathogenesis of knee OA. The more severe the disease, the higher the content. NOThe content of NO in serum of group A was lower than that of group B and C at each time point (P <0.05), indicating that Xuelian injection can effectively inhibit the production of nitric oxide in the pathological process of osteoarthritis. (3) The test showed that the SOD activity in the synovial tissue of the animals in group A was significantly higher than that in groups B and C (P <0.05), while the content of MDA was significantly lower than that in groups B and C.

Xuelian injection special safety experimental study to evaluate the safety of its medication. Methods: The guinea pig active systemic allergy test, the rat passive skin allergy test, the rabbit muscle irritation test and the hemolytic test were performed to observe whether Xuelian injection Can cause allergies and muscle irritation, whether there is hemolytic effect. Result: Xuelian injection does not show allergic reactions after administration in guinea pigs and rats, no significant irritation and no significant hemolytic effect after intramuscular injection. Conclusion: Xuelian injection The results of special safety experiments show that the medication is safe and reliable.

Understand whether Xuelian injection has long-term toxicity and provide reference for clinical application. Methods: Rats were injected with different doses of Xuelian injection by intraperitoneal injection for 90 days, and observation was continued for 14 days. Results: After 90 days of continuous injection, the rats did not show blood biochemical changes such as appearance, blood routine, liver and kidney function, and toxicity of 13 organ tissues. Conclusion: The drug has no obvious toxic and side effects, and it is safe for clinical use.