What Are the Most Common Clotrimazole Side Effects?

Clotrimazole vaginal tablets are indicated for vaginal inflammation caused by fungi, usually Candida; infectious leucorrhea caused by yeast; and secondary infections caused by susceptible bacteria.

Clotrimazole vaginal tablets are indicated for vaginal inflammation caused by fungi, usually Candida; infectious leucorrhea caused by yeast; and secondary infections caused by Kanintin-susceptible bacteria.
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Drug Name
Clotrimazole vaginal tablets
Drug type
OTC Class A, topical drugs, essential drugs
Use classification
Azoles

Clotrimazole vaginal tablets ingredients

The main ingredients of this product are: clotrimazole.
Chemical name: 1-[(2-chlorophenyl) diphenylmethyl] -1H-imidazole.
Chemical Structure:

Molecular formula: C 22 H 17 CIN 2
Molecular weight: 344.84
Excipients: calcium lactate pentahydrate, lactose, cellulose microcrystals, corn starch, crospovidone, magnesium stearate, silicon dioxide, hypromellose.

Clotrimazole Vaginal Tablet Properties

This product is off-white to light yellow tablets.

Clotrimazole vaginal tablets indications

Fungal infections are usually vaginal inflammation caused by Candida; infectious leucorrhea caused by yeast; and secondary infections caused by Kanintin-susceptible bacteria.

Clotrimazole vaginal tablets specifications

0.5 grams.

Clotrimazole vaginal tablets usage dosage

Vaginal administration. 1 tablet before bedtime, 1 tablet is a course of treatment. Place the tablet deep in the vagina with or without a dispenser. (See picture description for details)
Generally, it can be used once, and if necessary, a second treatment can be performed after 4 days.
How to use the medicine dispenser:
1) Take out the dispenser from the packaging box, pull the lever (Part A) of the dispenser, put half of the vaginal tablet into the part of the dispenser, and the other half outside the dispenser. When you put it inside the vagina, use Use your fingers to lightly press the lever (Part A) of the dispenser.
2) When administering medicine, it is best to use the supine position, and carefully place the medicine dispenser with tablets into the deep vagina.
3) Gently push Part A of the dispenser and place the tablet in the correct position in the vagina. Then remove the dispenser.
4) Graphic illustration of putting a vaginal tablet without a dispenser.
Recommendation: It is best not to perform the above treatments during menstruation.

Clotrimazole vaginal tablets adverse reactions

Occasionally, skin reactions (such as burning, stinging, or reddening) occur in the area of application. There may be varying degrees of allergic reactions in individual cases, which may affect the skin (such as itching, erythema), the respiratory system (such as shortness of breath), the cardiovascular system (such as reduced blood pressure or even impaired consciousness) or gastrointestinal Reactions (such as nausea, diarrhea).

Clotrimazole vaginal tablets contraindications

Do not use this medicine if you are known to be allergic to clotrimazole or other ingredients in the medicine.

Clotrimazole vaginal tablets precautions

In the following cases, you should use this product with special care and under the guidance of a physician:
1. Have a vaginal fungal infection for the first time.
2. This fungal infection has occurred more than 4 times in the past 12 months.
3. Medicines should be kept out of the reach of children.
4. Put the medicine dispenser in the box and remove it when needed. Once the tablet is placed in the dispenser, it should be used immediately. After use, discard the dispenser.

Clotrimazole vaginal tablets for pregnant and lactating women

It is important to use a Kennet vaginal tablet under the guidance of a doctor during pregnancy: during pregnancy, treatment is best performed by a physician, or do not use an applicator when using a Kennet vaginal tablet. Special care should be taken early in pregnancy, taking care not to use the dispenser.

Clotrimazole vaginal tablets for children

Patients under the age of 18 are not allowed to use Kenneth's vaginal tablets or can only be applied under the guidance of a physician. Because there are no reports of clinical studies in this age group.

Clotrimazole vaginal tablets for elderly

This experiment was not performed and there are no reliable references.

Clotrimazole vaginal tablets drug interactions

No known interactions with other drugs.
The ingredients in this product (especially stearates) can damage the function of latex products (such as condoms and vaginal diaphragms). If used at the same time, the safety of such products may be reduced.

Clotrimazole vaginal tablets overdose

This experiment was not performed and there are no reliable references.

Pharmacological effects of clotrimazole vaginal tablets

Pharmacological effects:
Clotrimazole produces an antifungal effect by inhibiting ergosterol synthesis. Inhibition of ergosterol synthesis results in impaired structure and function of the cytoplasmic membrane.
Clotrimazole has a spectrum of antifungal activity in vivo and in vitro, including skin fungi, yeasts, and molds.
Under appropriate experimental conditions, the minimum inhibitory bacteria concentration range for these types of fungi is below 0.062-4 (-8) g / ml substrate. Depending on the concentration at the site of infection, clotrimazole works by inhibiting fungi or fungicidal, depending on the concentration of clotrimazole at the site of infection. The in vitro activity of the drug is to limit the proliferation of fungal components, and fungal spores are only slightly sensitive to the drug.
In addition to its antifungal effect, this product also produces Trichomonas vaginalis, Gram-positive microorganisms (Streptococcus / Staphylococcus) and Gram-negative microorganisms (Bacteroides / Vagina genobacterium) effect.
In vitro, clotrimazole has an inhibitory effect on the proliferation of Corynebacterium and Gram-positive cocci other than Enterococcus, with a bacteriostatic concentration of 0.5-10 g / ml substrate. When the concentration reaches 100 g / ml, it can play a role in killing Trichomonas.
Primary resistant variants are rare in sensitive fungal species. To date, only sporadic cases of secondary resistance to sensitive fungi have been observed under treatment conditions.
Toxicology research:
In various animals, toxicological studies using intravaginal or topical methods have shown that the vagina and the site of the drug are well tolerated.
Preclinical data show that according to routine studies of toxicity, genotoxicity, and reproductive toxicity performed after single doses and repeated administration, the drug has no particular harm to humans.

Pharmacokinetics of Clotrimazole Vaginal Tablets

Pharmacokinetic studies performed after vaginal administration have shown that only a small amount of clotrimazole can be absorbed (3% and 3% -10% of the administered dose, respectively). The clotrimazole that has been absorbed is rapidly metabolized in the liver to form non-pharmacologically active metabolites, resulting in a peak plasma concentration of clotrimazole of less than 10 ng / ml after vaginal administration of 0.5 g, indicating that clotrimazole is administered intravaginally. No measurable systemic effects or side effects occur afterwards.

Clotrimazole Vaginal Tablets Storage

Please store kannet vaginal tablets in the manufacturer's aluminum foil bag and open them before use.
Store below 25 ° C. Before use, please check the expiration date marked on one end of the carton and on the aluminum foil bag. The expiration date is marked on it. Do not use it after the expiration date.

Clotrimazole vaginal tablet packaging

There is one tablet per box, and a disposable dispenser is included in the box. Aluminum-plastic packaging.

Clotrimazole vaginal tablet expiration date

48 months.

Clotrimazole vaginal tablet implementation standard

Import drug registration standard JX20060070 [1]

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