What Are the Medical Uses of Sodium Salicylate?

Sodium salicylate is used less frequently for rheumatic fever and rheumatoid arthritis.

Drug Name: Sodium salicylate

Drug type: prescription
Use classification: Carboxylic acids

Sodium salicylate ingredients

The main ingredients of this product are: sodium salicylate.

Chemical name: Sodium o-hydroxybenzoate

Molecular formula: C ₇ H ₅ NaO

Molecular weight: 160.10

Traits of sodium salicylate

This product is white or reddish flakes, which is easy to deteriorate when exposed to light.

Indications for Sodium Salicylate

Once used for the treatment of rheumatic fever and rheumatoid arthritis, it is now rarely used.

Specifications of Sodium Salicylate

(1) 0.3g (2) 0.5g

Dosage of sodium salicylate

Oral 0.5-1.0g once, 3 times a day.

Adverse reactions of sodium salicylate tablets

The main adverse reactions of this product are gastrointestinal reactions and salicylic acid reactions, manifested as nausea, vomiting, headache, dizziness, tinnitus and hearing and vision loss.

Tabs of sodium salicylate

Those who are allergic to salicylic acid drugs are prohibited.

Precautions for sodium salicylate tablets

1. Use with caution in patients with liver and kidney dysfunction.
2. Use with caution in patients with peptic ulcer.
3 Taking sodium bicarbonate together can reduce the blood concentration of this product and reduce the efficacy.
4 Note the effect of high sodium on disease.
5. Once used for the treatment of rheumatic fever and rheumatoid arthritis, it is now rarely used.

Sodium salicylate for pregnant and lactating women

Sodium salicylate easily penetrates the placenta and can induce teratogenesis, so pregnant women are prohibited.

Sodium salicylate tablets drug interactions

1. This product can enhance their toxicity when used in combination with other salicylic acid drugs.
2. When this product is combined with dicoumarin, the latter is replaced from the plasma protein binding site, which increases the blood concentration of free dicoumarin, enhances its anticoagulant effect, and easily causes bleeding.
3 This product can also replace the sulfonylurea hypoglycemic agent mesotrione, enhance its hypoglycemic effect, and easily cause hypoglycemic reactions.
4 Combined with adrenal corticosteroids, the anti-inflammatory effect of hormones is also enhanced due to protein replacement, but the effect of inducing ulcers is also enhanced.
5. This product reduces the excretion of methotrexate from the renal tubules and enhances its toxicity.
6. In combination with furosemide, salicylic acid excretion is reduced due to competition with the renal tubular secretion system, causing accumulation poisoning.

Pharmacology and Toxicology of Sodium Salicylate Tablets

The active ingredient of this product is salicylic acid. Its mechanism of action is similar to that of aspirin. It inhibits cyclooxygenase and reduces the synthesis of prostaglandins, which has anti-inflammatory, anti-rheumatic and antipyretic and analgesic effects. Its anti-inflammatory and anti-rheumatic effects are similar to aspirin, but the antipyretic and analgesic effects are weak. This product has no anti-platelet aggregation effect.
Acute toxicity test results: The intraperitoneal injection of LD ₅₀ in rats was 780 mg / Kg.

Pharmacokinetics of sodium salicylate tablets

This product is a metabolite of aspirin. It is absorbed quickly and completely after oral administration. It can be distributed in all tissues of the body and can also penetrate into the joint cavity and cerebrospinal fluid. In liver metabolism, the metabolites are mainly salicylic acid and glucuronic acid conjugates, and a small part is gentisic acid. This product is a metabolite of aspirin. According to the pharmacokinetic study of aspirin, the plasma protein binding rate of salicylic acid is 65% to 90%, which is mainly excreted from the kidney. When the dose is small, t _1/2 is 2 to 3 Hours, and more than 20 hours at high doses.