What Are the Most Common Isotretinoin Side Effects?

Telsil gum is an acne cure. It is suitable for severe acne, especially for nodular cystic acne. It is suitable for severe acne, especially for nodular cystic acne, and can also be used for diseases such as red hair pityriasis. Telsil capsules should be used under the guidance of a doctor, orally 10 mg (1 capsule) once orally, 2-3 times a day (0.1-1.0 mg / kg per weight per day), and then 10 mg (1 capsule) once a month , 1-2 times a day.

Tyres isotretinoin acid pill

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Telsil gum is an acne cure. It is suitable for severe acne, especially for nodular cystic acne. It is suitable for severe acne, especially for nodular cystic acne, and can also be used for diseases such as red hair pityriasis. Telsil capsules should be used under the guidance of a doctor, orally 10 mg (1 capsule) once orally, 2-3 times a day (0.1-1.0 mg / kg per weight per day), and then changed to 10 mg (1 capsule) once a month. , 1-2 times a day.

Drug Name

Tyres isotretinoin acid pill

Main indications

Severe acne

Dosage

10mg once a day (1 capsule)

Adverse reactions

Conjunctivitis, corneal opacity in severe cases, etc.

This medicine is fat-soluble, taking medicine at meals can promote absorption and treat 2-4

Tyres isotretinoin acid pills adverse reactions

Schematic of adverse reactions

1. The side effects of this medicine are similar to the clinical manifestations of excessive vitamin A. Common side effects include dry lips and skin, cheilitis, desquamation, pain, rash, increased skin fragility, palmar and palm peeling, ecchymosis, and secondary symptoms Infection, etc.

2. Conjunctivitis, severe corneal opacities, visual impairment, papillary edema, headache, dizziness, mental symptoms, depression, and benign cerebral hypertension;

3. Loose hair and soft nails;

4. Osteoporosis, muscle weakness, pain, bone and bowel symptoms, epistaxis, etc.

5. Pregnancy medication can cause spontaneous abortion and fetal developmental abnormalities;

6. Laboratory tests can cause rapid erythrocyte sedimentation, elevated liver enzymes, elevated blood lipids, elevated blood sugar, and platelet decline.

7. Depression

8. Hearing

9. Suicide (once in one case)

Most of the above-mentioned side effects are reversible and can be gradually recovered after stopping the drug. The severity of the side effects is related to the dosage of the drug, the length of the course of treatment and the tolerance of the individual.

Mild adverse reactions may not need to be discontinued or used in a reduced amount. Serious adverse reactions should be discontinued immediately and go to the hospital for treatment. Most of the above-mentioned adverse reactions are reversible, which can be gradually recovered after stopping the drug.

Tyres isotretinoin acid pill taboo

Pregnant women, lactating women, liver and kidney insufficiency, patients with excessive vitamin A and hyperlipidemia are prohibited.

Precautions for Tyres isotretinoin

1. Avoid taking this medicine at the same time as vitamin A and tetracycline;

2. Women of childbearing age should take a pregnancy test before and after taking the medicine;

3. Don't donate blood during medication and within three months after discontinuation;

4 Avoid excessive sunlight and UV rays;

5. Diabetes, obesity, alcoholism, hyperlipidemia, and lipid metabolism disorders should be used with caution;

6. Acne symptoms may be temporarily exacerbated at the beginning of treatment. If there are no other abnormalities, you can continue to take the drug under close observation. It is not appropriate to take other anti-acne drugs that are keratinous or exfoliative;

7. If necessary, mild external medicine can be used as adjuvant treatment.

[Medication for pregnant women and lactating women] Pregnant women and lactating women are prohibited. Women of childbearing age or their spouses should be strictly contracepted during the three months before and after taking the medicine, and never get pregnant.

[Children's medication] The safety of children is unclear. Overdose can lead to changes in bone structure, including precocious disc fusion in children.

[Medication for elderly patients] Those with liver and kidney insufficiency are prohibited.

medicine interactions

1. The combination of isotretinoin and tetracycline antibiotics can lead to the production of false "brain tumors" and cause benign cerebral pressure. The clinical manifestations are hypertension, dizziness and visual impairment with headache.

2. The simultaneous use of isotretinoin and vitamin A can produce symptoms similar to those of vitamin A overdose.

3. The simultaneous application of isotretinoin and carbamazepine can cause the blood concentration of carbamazepine to decrease, and simultaneous use with warfarin can enhance the therapeutic effect of warfarin, and methotrexate When used together with MTX, it can increase the damage to the liver due to the increase of MTX blood concentration.

[Specifications] 10mg

[Storage] shading, sealed, and stored in a cool and dry place.

[Packing] Aluminum-plastic packaging: 10 tablets per board, 2 boards per box

Special Tips for Tyres Isotretinoin Capsules

Although isotretinoin is effective in treating severe acne, it has many adverse reactions and has a high probability of recurrence after discontinuation, which deserves attention. The clinical adverse reactions of isotretinoin mainly include the following 6 aspects:

Adverse reactions of the skin and mucosa: This is the most common adverse reaction of oral isotretinoin. The larger the oral dose, the higher the incidence of adverse reactions. Cheilitis is the most common, with an incidence rate of 100%. The symptoms are dry, chapped, peeling, and bleeding of the lip mucosa, similar to exfoliative dermatitis. Nearly 30% to 50% of patients have dry and bleeding nasal mucosa, dry and itchy skin, and dry eyes. It is obvious to patients with allergies and xerosis, contact lens wearers should not use or wear contact lenses during the application of this product.

Teratogenic effects: Animal experiments have proven that oral isotretinoin can cause developmental abnormalities, miscarriages and stillbirths. Early administration in the formation of fetal organs can cause abnormal development of the central nervous system and cardiovascular system; administration in the third trimester can cause fetal limb shortage and urinary system defects. Therefore, when isotretinoin is used clinically, women of childbearing age should be required to take effective contraceptive measures one month before and during treatment, and they can only give birth six months after the end of treatment.

Effects on bones: Long-term application of isotretinoin can cause bone hypertrophy, calcification of tendon ligaments, osteoporosis, and epiphyseal atresia, which affects the growth of children and adolescents. Bone hypertrophy and tendon ligament calcification are the most common, and the incidence is related to the dose and time of medication. Bone hypertrophy can be detected in about 10% of patients treated with isotretinoin at a dose of 1 to 2 mg per kilogram of body weight per day and a course of treatment for 4 to 5 months. Therefore, isotretinoin and glucocorticoids, Other vitamin A drugs (including vitamin A) are used together. Do not use isotretinoin for a long period of time. When the condition improves significantly, use maintenance or other drugs with fewer adverse reactions to consolidate the treatment. Patients with long-term use of isotretinoin can have regular X-ray examinations. Usually eat more calcium-rich foods such as milk, pork rib soup, seafood, etc., osteoporosis patients can be given calcium supplementation treatment.

Impact on mental activity: There are reports in the literature that since the isotretinoin was marketed in 1982 and May 2000, the US Food and Drug Administration (FDA) has reported 431 cases of mental disorders after taking isotretinoin, 37 of which Patients committed suicide, 110 patients were hospitalized with emotional depression, suicidal thoughts or suicidal tendency, and 284 patients were emotionally depressed but not hospitalized. The effect of oral isotretinoin on mental activity is related to the time of use of the drug; the symptoms can be reduced after the drug is discontinued or psychotherapy, and the symptoms can appear or worsen after re-administration. Because acne is a disease of incapacitation, facial rashes bring tremendous mental stress to patients' lives, studies, work and communication. Therefore, some scholars believe that acne is a psychosomatic disease, and there are a large number of reports that acne itself can cause Patients have varying degrees of depression and trouble, and even have suicidal tendency and suicidal behavior. Therefore, the mental abnormality caused by oral isotretinoin can only show a certain correlation with isotretinoin, without a clear causal relationship. However, clinicians should be alert to the possibility of depression with isotretinoin. It should be avoided in patients with established depression.

Neuromuscular adverse reactions: Foreign literature has reported that oral isotretinoin can cause headache, dizziness, drowsiness, myalgia, and elevated blood creatine kinase (CK). Patients with elevation should avoid or reduce their use. Patients with muscle symptoms should avoid strenuous exercise.

Abnormal laboratory tests: Oral isotretinoin can cause total cholesterol and triglyceride levels to rise. Patients with hyperlipidemia, obesity, diabetes, etc. should avoid isotretinoin as much as possible.