What Are the Most Common Reactions to Penicillin?

In clinical application of penicillins, allergic reactions, including rash, drug fever, angioedema, serotype, and anaphylactic shock, are collectively referred to as penicillin anaphylactic reactions, of which anaphylactic shock is the most severe.

Penicillin-like allergic reactions

When penicillins are used clinically, allergic reactions often occur, including rash,

In application

The test methods include scratch, patch, eye drop, and intradermal injection.

It should be noted that the test itself may also cause anaphylactic shock. The necessary first-aid medication should be prepared before the skin test. Patients should be closely observed during the skin test. If shock occurs, 0.1% epinephrine injection 0.5 ~ 1ml should be injected intramuscularly or subcutaneously (pediatric reduction). If necessary, it can be repeated once a few minutes or intravenously or intracardially. . And according to need, infusion, oxygen, instillation of adrenocortical hormone (hydrocortisone or flumetasone), application of booster drugs and other necessary first aid measures.

People with negative skin tests may also have an allergic reaction during medication. Therefore, after injecting the drug, the patient should be closely observed for 20 minutes, and no reaction should occur before leaving. In case of any type of allergic reaction or the patient complains of discomfort, the drug should be stopped immediately. If anaphylactic shock occurs, first aid should be performed as described above.

People with a history of allergies to penicillin or those with an allergic constitution (such as those with urticaria, eczema, bronchial asthma, etc.) must use penicillin regardless of skin tests and medications.

There is a cross-allergy relationship between different penicillin varieties. Penicillin drugs can be used for skin tests before use. It is also feasible to prescribe the opinion of which penicillin should be used for the skin test (the concentration of the test solution to be used is 300 g / ml).